Review
Neurosciences
Aleksi Kokkonen, Emma A. Honkanen, Daniel T. Corp, Juho Joutsa
Summary: Deep brain stimulation (DBS) is an effective treatment for various brain disorders, but its mechanisms of action and detailed molecular effects still need further investigation.
Review
Immunology
Wenxia Dong, Ning Wang, Zhe Qi
Summary: The prevalence of brain cancer is increasing and brings significant healthcare challenges. Immunotherapies present diagnostic imaging challenges for brain tumors. Effective neuroimaging techniques are necessary for diagnosing and monitoring brain tumors, but differentiating between tumors and necrotic lesions or inflamed tissues remains a challenge. This review summarizes recent advances in neuroimaging methods for enhancing brain tumor diagnosis and evaluating inflamed lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Benjamin Haenisch, Justine Y. Hansen, Boris C. Bernhardt, Simon B. Eickhoff, Juergen Dukart, Bratislav Misic, Sofie Louise Valk
Summary: This study investigates the role of neurotransmitter transporter and receptor molecules in the structure-function relationships in the human brain. Using positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors, the researchers discovered three main spatial gradients of chemoarchitectural similarity in the cortical and subcortical regions of the brain. The findings show that the organization of the receptome shares similarities with functional and structural brain anatomy.
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Julian L. Goggi, Shivashankar Khanapur, Boominathan Ramasamy, Siddesh V. Hartimath, Tang Jun Rong, Peter Cheng, Yun Xuan Tan, Xin Yi Yeo, Sangyong Jung, Stephanie Shee Min Goay, Seow Theng Ong, You Yi Hwang, K. George Chandy, Edward G. Robins
Summary: This study developed a new Kv1.3 targeting radiopharmaceutical that successfully predicted the response to immune checkpoint inhibitors in a murine model of colon cancer.
Review
Medicine, General & Internal
Alan Miranda, Daniele Bertoglio, Sigrid Stroobants, Steven Staelens, Jeroen Verhaeghe
Summary: Anesthesia is a major limitation in translating preclinical brain PET scans to clinical settings, as it can affect the accuracy of tracer results. Despite advances in motion correction methods, wider adoption of this technique in brain research is needed.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Christophe van de Wiele, Sezgin Ustmert, Bart De Spiegeleer, Pieter-Jan De Jonghe, Mike Sathekge, Maes Alex
Summary: Various potential PET-apoptosis imaging radiopharmaceuticals have been developed to assess the response to cancer treatment. Some of these radiopharmaceuticals showed enhanced uptake in xenografted tumors in mice, but to varying degrees. Two validated radioligands showed favorable characteristics in healthy individuals, but did not significantly affect bone marrow. Further research is needed to evaluate the clinical value of these radiopharmaceuticals for apoptosis imaging in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Loredana G. G. Marcu, Leyla Moghaddasi, Eva Bezak
Summary: Cancer stem cells are crucial in tumor development, growth, and spread. Their unique properties make them resistant to treatment, often leading to therapy failure. Research into identifying, targeting, and eliminating these cells is believed to revolutionize oncology treatment. This review discusses state-of-the-art functional imaging techniques for identifying cancer stem cells through various pathways and mechanisms. It presents in vivo molecular techniques that are currently available or awaiting clinical implementation while highlighting challenges and future prospects for cancer stem cell imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Teng Zhang, Shuang Wu, Xiaohui Zhang, Yiwu Dai, Anxin Wang, Hong Zhang, Mei Tian
Summary: Quantification approaches of PET imaging in living brains have been recommended for clinical diagnosis of neurological disorders. This review compared PET template-based and MRI-aided spatial normalization approaches. The study also discussed ROI-based and voxel-wise quantitative methods, as well as the concerns and clinical applications of these approaches. A recipe for PET spatial normalization and quantification was concluded to improve diagnosis accuracy in clinical practice.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Martin Kocher, Christiane Jockwitz, Philipp Lohmann, Gabriele Stoffels, Christian Filss, Felix M. Mottaghy, Maximilian I. Ruge, Carolin Weiss Lucas, Roland Goldbrunner, Nadim J. Shah, Gereon R. Fink, Norbert Galldiks, Karl-Josef Langen, Svenja Caspers
Summary: This study used structural MRI and amino acid PET in conjunction with brain atlases and elastic registration techniques to investigate the impact of treatment-related brain damage on cognitive functioning in well-functioning WHO Grade III/IV glioma patients. The results showed that T2/FLAIR hyperintensities caused by radiation therapy significantly impaired cognitive performance, especially affecting the left hemisphere functional nodes and fiber tracts, which were highly correlated with verbal episodic memory dysfunction.
Article
Chemistry, Analytical
Siyang Liu, Ye Liu, Zhe Zhang, Xiaodong Wang, Yicheng Yang, Kai Sun, Jiangbo Yu, Daniel T. Chiu, Changfeng Wu
Summary: This study developed a near-infrared optical transducer to monitor glucose variations in cerebrospinal fluid, and observed abnormal glucose uptake in transgenic mice with brain tumors.
ANALYTICAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei Tian, Chuantao Zuo, A. Cahid Civelek, Ignasi Carrio, Yasuyoshi Watanabe, Keon Wook Kang, Koji Murakami, John O. Prior, Yan Zhong, Xiaofeng Dou, Congcong Yu, Chentao Jin, Rui Zhou, Fengtao Liu, Xinyi Li, Jiaying Lu, Hong Zhang, Jian Wang
Summary: This article introduces the international consensus and practice guideline, aiming to promote the standardized use of presynaptic dopaminergic PET imaging in parkinsonism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Julian L. Goggi, Siddesh V. Hartimath, Shivashankar Khanapur, Boominathan Ramasamy, Zan Feng Chin, Peter Cheng, Hui Xian Chin, You Yi Hwang, Edward G. Robins
Summary: Studies suggest that using metformin as an adjuvant therapy can enhance the immunological memory response in cancer treatment with immune checkpoint inhibitors (ICI). However, some combination therapies may exacerbate the immune response and lead to adverse immune-related events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Steven W. Poser, Oliver Otto, Carina Arps-Forker, Yan Ge, Maik Herbig, Cordula Andree, Konrad Gruetzmann, Melissa F. Adasme, Szymon Stodolak, Polyxeni Nikolakopoulou, Deric M. Park, Alan Mcintyre, Mathias Lesche, Andreas Dahl, Petra Lennig, Stefan R. Bornstein, Evelin Schroeck, Barbara Klink, Ronen R. Leker, Marc Bickle, George P. Chrousos, Michael Schroeder, Carlo Vittorio Cannistraci, Jochen Guck, Andreas Androutsellis-Theotokis
Article
Immunology
Monika Rabenstein, Sabine Ulrike Vay, Stefan Blaschke, Helene Luise Walter, Anne Ladwig, Gereon Rudolf Fink, Maria Adele Rueger, Michael Schroeter
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Immunology
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Moniere, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Neurosciences
J. Baermann, H. L. Walter, A. Pikhovych, H. Endepols, G. R. Fink, M. A. Rueger, M. Schroeter
Summary: The study evaluated CatWalk's capability for assessing functional outcomes after photothrombotic stroke in mice, finding that while CatWalk detected some impairments, a composite neuroscore may be more sensitive and precise in quantifying hemisyndromes induced by photothrombosis.
NEUROSCIENCE LETTERS
(2021)
Article
Geriatrics & Gerontology
Johannes Boltze, Jaroslaw A. Aronowski, Jerome Badaut, Marion S. Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R. Dave, Nadine Didwischus, Rick M. Dijkhuizen, Thorsten R. Doeppner, Jens P. Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A. Gregson, Edith Hamel, Daniel F. Hanley, Wolfgang Haertig, Friedhelm C. Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S. Karuppagounder, Richard F. Keep, Inga K. Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A. S. Metz, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M. Planas, Nikolaus Plesnila, Ami P. Raval, Maria A. Rueger, Lauren H. Sansing, Farida Sohrabji, Charlotte J. Stagg, R. Anne Stetler, Ann M. Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U. Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille
Summary: The past decade has witnessed significant advancements in both diagnosis and treatment of cerebrovascular diseases, with the introduction of thrombectomy in ischemic stroke and the identification of new therapeutic targets based on deeper understanding of pathomechanisms. Additionally, translational aspects are increasingly recognized in basic science studies, enhancing their predictive value for clinical application.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Sabine Ulrike Vay, Daniel Navin Olschewski, Helena Petereit, Felix Lange, Nilufar Nazarzadeh, Elena Gross, Monika Rabenstein, Stefan Johannes Blaschke, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger
Summary: The glycoprotein osteopontin is considered a crucial regulator in CNS disorders like ischemic stroke, influencing cell growth, adhesion, and survival. Research suggests that osteopontin can impact the activation state and survival of astrocytes, making it a promising target for experimental therapies aimed at modulating neuroregeneration and repair.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Clinical Neurology
Stefan J. Blaschke, David Ellenberger, Peter Flachenecker, Kerstin Hellwig, Friedemann Paul, Dieter Poehlau, Christoph Kleinschnitz, Paulus S. Rommer, Maria A. Rueger, Uwe K. Zettl, Alexander Stahmann, Clemens Warnke
Summary: After the introduction of MRI-based McDonald criteria in 2001, the average time to diagnosis of multiple sclerosis in younger adults with relapsing onset has decreased in Germany. However, the diagnosis time remains longer and unchanged in pediatric onset MS patients.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Multidisciplinary Sciences
Anna Katharina Schlusche, Sabine Ulrike Vay, Niklas Kleinenkuhnen, Steffi Sandke, Rafael Campos-Martin, Marta Florio, Wieland Huttner, Achim Tresch, Jochen Roeper, Maria Adele Rueger, Igor Jakovcevski, Malte Stockebrand, Dirk Isbrandt
Summary: The development of the cerebral cortex relies on the controlled division of neural stem and progenitor cells, with ion channels playing a crucial role in shaping the intrinsic properties of precursor cells and neurons. Dysfunction in HCN channels can impair proliferation and cause microcephaly in rodents, highlighting the importance of ion channels in cortical development in mammals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Stefan J. Blaschke, Lukas Hensel, Anuka Minassian, Susan Vlachakis, Caroline Tscherpel, Sabine U. Vay, Monika Rabenstein, Michael Schroeter, Gereon R. Fink, Mathias Hoehn, Christian Grefkes, Maria A. Rueger
Summary: The study showed that network parameters computed for both mouse models of stroke and humans follow a similar pattern in the postacute stroke phase. Parameters indicating the global communication structure's facilitation, such as small worldness and characteristic path length, were similarly changed in humans and mice in the first days after stroke. Additionally, small worldness correlated with concurrent motor impairment in humans and a negative correlation between initial small worldness and motor recovery was observed in mice during the subacute phase.
Article
Neurosciences
Jella-Andrea Abraham, Stefan Blaschke, Samar Tarazi, Georg Dreissen, Sabine U. Vay, Michael Schroeter, Gereon R. Fink, Rudolf Merkel, Maria A. Rueger, Bernd Hoffmann
Summary: The study suggests that neural stem cells are affected by pulsatile strain, influencing their quiescence and cytoskeletal organization. In addition, stem cells and their young progeny exhibit characteristic and distinct mechanoresponsiveness compared to other cell types in mammalian organisms.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Ines Klein, Janne Boenert, Felix Lange, Britt Christensen, Meike K. Wassermann, Martin H. J. Wiesen, Daniel Navin Olschewski, Monika Rabenstein, Carsten Mueller, Helmar C. Lehmann, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger, Sabine Ulrike Vay
Summary: Glia cells play a critical role in mediating the side effects of paclitaxel, influencing their (neuro-) inflammatory and (neuro-) regenerative properties and their interaction with other glia cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Helene Luise Walter, Anton Pikhovych, Heike Endepols, Steffen Rotthues, Johannes Baermann, Heiko Backes, Mathias Hoehn, Dirk Wiedermann, Bernd Neumaier, Gereon Rudolf Fink, Maria Adele Rueger, Michael Schroeter
Summary: In this study, it was found that tDCS can promote functional recovery after stroke by impacting cellular processes such as neurogenesis and microglial activation. Cathodal tDCS showed greater effects on functional recovery, neurogenesis, and microglial activation compared to anodal tDCS.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Meeting Abstract
Neurosciences
D. N. Olschewski, F. Lange, C. Kulka, N. Nazarzadeh, S. Blaschke, J. -A. Abraham, R. Merkel, B. Hoffmann, M. Schroeter, G. R. Fink, M. A. Rueger, S. U. Vay
Article
Neurosciences
Stefan J. Blaschke, Seda Demir, Anna Koenig, Jella-Andrea Abraham, Sabine U. Vay, Monika Rabenstein, Daniel N. Olschewski, Christina Hoffmann, Marco Hoffmann, Nils Hersch, Rudolf Merkel, Bernd Hoffmann, Michael Schroeter, Gereon R. Fink, Maria A. Rueger
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Review
Hematology
Jorge Garcia Borrega, Philipp Goedel, Maria Adele Rueger, Oezguer A. Onur, Alexander Shimabukuro-Vornhagen, Matthias Kochanek, Boris Boell