Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 17, Issue 3, Pages 272-283Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161211795049723
Keywords
Apoptosis; breast cancer; BCL-2; Fas; TNF-alpha; TRAIL; PARP inhibitors
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Apoptosis plays an important role in development, growth, differentiation, altered gravity conditions, tissue homeostasis, immune defense, and cancer. It can be initiated by external signals via death receptors, but may also emerge from mitochondria. Today most of the key players in cellular apoptosis regulation are identified and can be targeted by therapeutic strategies. In this review we focus on recent development of drugs, which interfere with apoptosis and are currently used or tested for treatment of breast cancer. These novel agents include those targeting the extrinsic pathway such as Fas, tumor necrosis factor-alpha and tumor necrosis factor related apoptosis-inducing ligand, as well as drugs targeting the intrinsic Bcl-2 family pathway, or drugs inhibiting repair enzymes such as Poly (ADPribose) polymerase (PARP) inhibitors. Their function will be explained, their role in tumor biology and actual clinical studies will be discussed.
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