Review
Pharmacology & Pharmacy
Kang Geng, Xiumei Ma, Zongzhe Jiang, Wei Huang, Chenlin Gao, Yueli Pu, Lifang Luo, Youhua Xu, Yong Xu
Summary: Recent studies have shown that the interaction between immune and metabolic responses is crucial for maintaining tissue and organ homeostasis, playing a significant role in the development of chronic diseases. In diabetic wound healing, the abnormal activation of innate immune cells is essential in triggering and sustaining inflammation. Targeting these innate immune pathways and reprogramming immune cell phenotypes show great potential in diabetic wound therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Maurizio Sabbatini, Valeria Magnelli, Filippo Reno
Summary: Neutrophils extracellular traps (NETs) have both positive effects, such as aiding wound healing, and negative effects, which can lead to tissue physiological issues in certain pathological conditions. Recent research suggests there are additional positive physiological effects of NETs that warrant further investigation.
Review
Biochemistry & Molecular Biology
Kamila Raziyeva, Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kuat Kassymbek, Shiro Jimi, Arman Saparov
Summary: Skin wounds significantly impact the global healthcare system, with acute and chronic wounds being the two main types. The immune response is crucial for acute wound healing, but dysregulation can lead to chronic wounds characterized by persistent inflammation and delayed healing. Current research focuses on immunomodulatory therapeutic strategies to improve wound healing, targeting factors such as macrophage phenotype and inflammatory mediators.
Review
Immunology
Arnolda Jakovija, Tatyana Chtanova
Summary: The skin, as the body's largest organ, serves as a barrier to pathogens and the first line of immune defense. In the event of skin injury, a series of events contribute to wound repair, including inflammation, tissue formation, and tissue remodeling. Immune cells in the skin work alongside non-immune cells to clear pathogens, debris, and guide tissue regeneration. Disruption to the wound repair process can lead to chronic inflammation and non-healing wounds, which can promote skin cancer development by hijacking the wound healing response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Shuiqing Hu, Yan Fang, Xiang Chen, Tianlei Cheng, Miaoqing Zhao, Mingjian Du, Tuo Li, Minghao Li, Zhiqun Zeng, Yonglong Wei, Zhimin Gu, Conggang Zhang, Lijun Sun, Zhijian J. Chen
Summary: cGAS plays a crucial role in controlling the development of colitis-associated colon cancer by defending the integrity of the intestinal mucosa, suppressing inflammation, and promoting the proliferation of intestinal epithelial cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Aditya Kaul, Walker D. Short, Sundeep G. Keswani, Xinyi Wang
Summary: Hyaluronic acid plays a crucial role in wound healing by interacting with the immune system, with its molecular weight determining its immune-modulating effects on the repair process.
Article
Immunology
Brian J. Laight, Natasha A. Jawa, Kathrin Tyryshkin, David M. Maslove, J. Gordon Boyd, Peter A. Greer
Summary: Sepsis is caused by initial over-activation of the immune system in response to an infection or trauma, followed by suppression of the immune system. Enhancing FES in early sepsis and inhibiting it in late sepsis may improve the severity and outcome of septic illness.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Fan Mao, Xiaoying Zheng, Nai-Kei Wong, Wenjie Yi, Jingchen Song, Shiwei Fu, Zhiming Xiang, Shu Xiao, Yongbo Bao, Ziniu Yu, Yang Zhang
Summary: This study reveals the regulatory mechanisms of the Hippo pathway in immune responses of Crassostrea hongkongensis hemocytes, highlighting its importance in maintaining immune homeostasis and orchestrating hemocytic functions. It also demonstrates the divergence of the Hippo pathway's roles in marine invertebrate immunity from mammalian observations, indicating the need for further comparative studies across species.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Takahiro Manabe, Heamin Park, Takashi Minami
Summary: Wound healing is a complex process involving multiple cell types and signaling pathways, which can be easily impaired or dysregulated by the microenvironment, leading to the occurrence of various diseases. The calcium signaling pathway plays an important regulatory role in wound healing, affecting the progress of various healing steps.
INFLAMMATION AND REGENERATION
(2021)
Review
Pharmacology & Pharmacy
Elias Rawish, Manuela Sauter, Reinhard Sauter, Henry Nording, Harald F. Langer
Summary: This review explores the mutual relationship between immune activation and thrombus formation mechanisms, particularly focusing on how the complement system can modulate platelet activation. While some components of the complement system have been associated with platelets and shown to be functionally active in the micromilieu of platelet activation, the exact regulatory mechanisms and the consequences on tissue inflammation, damage, or recovery are still to be fully understood.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Maximiliane Winter, Barbara Heitplatz, Nils Koppers, Annika Mohr, Alexander D. Bungert, Mazen A. Juratli, Benjamin Struecker, Georg Varga, Andreas Pascher, Felix Becker
Summary: Intestinal macrophages play important roles in the healing process of intestinal anastomosis. They exhibit phase-specific functions and therapeutic interventions should consider their dual and timely defined role. Depletion of macrophages during the inflammatory phase reduces inflammation without compromising the microscopic healing. Depletion during the proliferative phase improves anastomotic healing despite reduced neoangiogenesis.
Article
Multidisciplinary Sciences
Nicolas Serafini, Angelique Jarade, Laura Surace, Pedro Goncalves, Odile Sismeiro, Hugo Varet, Rachel Legendre, Jean-Yves Coppee, Olivier Disson, Scott K. Durum, Gad Frankel, James P. Di Santo
Summary: Group 3 innate lymphoid cells (ILC3s) in the intestine remain activated for months after exposure to Citrobacter rodentium, leading to enhanced immune response and defense capability. These trained ILC3s undergo metabolic changes and exhibit enhanced proliferative capacity and IL-22 production.
Review
Biochemistry & Molecular Biology
Nyemkuna Fortingo, Samuel Melnyk, Sarah H. Sutton, Mitchell A. Watsky, Wendy B. Bollag
Summary: Inflammation plays a complex role in corneal wound healing. While acute inflammation is necessary to prevent infection, chronic or excessive inflammation can delay healing and worsen outcomes. Reductions in severe or chronic inflammation lead to better corneal clarity, thickness, and healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Yongyong Lai, Yinglei Xu, Fei Zhu
Summary: JAK plays a crucial role in the immune function of Scylla paramamosain, regulating the proliferation, phagocytosis, and apoptosis of immune cells through the modulation of gene expression. JAK affects the innate immune response of S. paramamosain against pathogens by influencing enzyme activities.
Article
Biochemistry & Molecular Biology
Judith C. J. Holzer-Geissler, Simon Schwingenschuh, Martin Zacharias, Johanna Einsiedler, Sonja Kainz, Peter Reisenegger, Christian Holecek, Elisabeth Hofmann, Barbara Wolff-Winiski, Hermann Fahrngruber, Thomas Birngruber, Lars-Peter Kamolz, Petra Kotzbeck
Summary: The treatment of chronic wounds poses a challenge for modern medicine due to the complex pathophysiology involved. Previous wound models used for studying chronic wounds lack translatability to patients and often overlook the impact of exaggerated inflammation. This study aims to investigate the role of prolonged inflammation in a porcine wound model using the TLR7 and TLR8 agonist resiquimod. The results demonstrate that prolonged inflammation delays wound healing, a common observation in chronic wounds. This model highlights the importance of inflammation in wound healing and provides insights into the progression of chronic wounds.