Article
Peripheral Vascular Disease
Yuuki Shimizu, Kazuhisa Kondo, Ryo Hayashida, Ken-ichiro Sasaki, Masanori Ohtsuka, Yoshihiro Fukumoto, Shinichiro Takashima, Oto Inoue, Soichiro Usui, Masayuki Takamura, Masashi Sakuma, Teruo Inoue, Tokuichiro Nagata, Yoshihiro J. Akashi, Yoshihiro Yamada, Tamon Kato, Koichiro Kuwahara, Kaoru Tateno, Yoshio Kobayashi, Rei Shibata, Toyoaki Murohara
Summary: This multicenter clinical trial demonstrated that autologous adipose-derived regenerative cell (ADRC) transplantation is safe and effective for therapeutic angiogenesis in patients with critical limb ischemia (CLI). The overall survival rate was 100% at the post-operative period and 6 months follow-up. 94.1% of limbs were free from major amputation for 6 months. The quality of life score, ulcer size, and walking distance also improved in a significant number of patients.
Article
Cardiac & Cardiovascular Systems
Junya Suzuki, Yuuki Shimizu, Kazuhito Tsuzuki, Zhongyue Pu, Shingo Narita, Shukuro Yamaguchi, Takeshi Katagiri, Etsuo Iwata, Tomohiro Masutomi, Yusuke Fujikawa, Rei Shibata, Toyoaki Murohara
Summary: In this study, we demonstrated that local injection of ADRCs can promote angiogenesis in response to tissue ischemia without promoting remote tumor growth in a mouse model. Our findings indicate that therapeutic angiogenesis to the ischemic hindlimb using ADRCs seems to be safe regarding remote tumor growth.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cell Biology
Furkan Yigitbilek, Sabena M. Conley, Hui Tang, Ishran M. Saadiq, Kyra L. Jordan, Lilach O. Lerman, Timucin Taner
Summary: MSCs from liver and adipose tissue showed similar proliferation and migration properties, but had differences in immunomodulatory and pro-angiogenic abilities. Selecting cell-based therapy according to the specific characteristics of different cell sources may be important for treating certain diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Ralf Rothoerl, Junee Tomelden, Eckhard Udo Alt
Summary: In this study, long-term results of 37 patients with facet joint syndrome treated with autologous unmodified adipose tissue-derived regenerative cells were observed. The patients reported improved quality of life after the treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Yi Qin, Gaoran Ge, Peng Yang, Liangliang Wang, Yusen Qiao, Guoqing Pan, Huilin Yang, Jiaxiang Bai, Wenguo Cui, Dechun Geng
Summary: In the past decade, adipose-derived stem cells (ADSCs) have gained increasing attention in the field of regenerative medicine due to their accessibility, multipotency, and active paracrine activity. This review discusses the challenges in translating ADSC-based therapies to clinical settings and proposes novel strategies to overcome the limitations. It also provides an update on the advancements in ADSC-based therapies in various fields of regenerative medicine.
Article
Cell & Tissue Engineering
Yoshio Sakai, Shinya Fukunishi, Masayuki Takamura, Kazunori Kawaguchi, Oto Inoue, Soichiro Usui, Shinichiro Takashima, Akihiro Seki, Akira Asai, Yusuke Tsuchimoto, Alessandro Nasti, Tuyen Thuy Bich Ho, Yasuhito Imai, Kenichi Yoshimura, Toshinori Murayama, Taro Yamashita, Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Takashi Wada, Kenichi Harada, Kazuhide Higuchi, Shuichi Kaneko
Summary: The study conducted a multi-institutional clinical trial using autologous ADRCs for liver cirrhosis patients, showing improved serum albumin concentration and prothrombin activity in most patients, with no trial-related adverse events observed. This treatment with autologous ADRCs obtained with the investigational trial device is safe and potentially promising for improving impaired hepatic reserve.
REGENERATIVE THERAPY
(2021)
Article
Cell Biology
Mingming Wang, Hongyan Zhan, Jianhua Wang, Hua Song, Jianhua Sun, Gang Zhao
Summary: This study demonstrates that CS can enhance the proliferation of ADSCs and improve their migration ability through inhibiting apoptosis and oxidative stress. CS also promotes the expression of CXCR4 in ADSCs and enhances their migration and angiogenic capacity. Importantly, CS improves the efficacy of ADSCs in wound healing both in vivo and in vitro, providing potential materials for the treatment of wound healing.
Editorial Material
Clinical Neurology
Kazuo Shigematsu, Naoyuki Komori, Kenichi Tahara, Hisakazu Yamagishi
Summary: Repeated administration of autologous adipose tissue-derived stem cells (ADSCs) for Parkinson's disease was proven to be safe and feasible, with potential therapeutic effects in the short-term. The results of this pilot study may provide insights for future more in-depth research.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Cell & Tissue Engineering
Xing Zhang, Yihong Jiang, Qun Huang, Zhaoyu Wu, Hongji Pu, Zhijue Xu, Bo Li, Xinwu Lu, Xinrui Yang, Jinbao Qin, Zhiyou Peng
Summary: Exosomes secreted by ADSCs overexpressing GLO-1 promoted endothelial cell protection and angiogenesis in diabetic mice with limb ischemia, showing promising potential for clinical treatment.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ekta Manocha, Alessandra Consonni, Fulvio Baggi, Emilio Ciusani, Valentina Cocce, Francesca Paino, Carlo Tremolada, Arnaldo Caruso, Giulio Alessandri
Summary: Pericytes, as a type of mesenchymal stromal cells, have a crucial role in tissue regeneration and vascular homeostasis. This study found that CD146(+) pericytes from adipose tissue may have a higher efficacy in promoting angiogenesis and vascular stabilization compared to CD146(-) pericytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Ming-Li Zou, Si-Yu Liu, Zi-Li Sun, Jun-Jie Wu, Zheng-Dong Yuan, Ying-Ying Teng, Yi Feng, Feng-Lai Yuan
Summary: The incidence of acute and chronic wound diseases is increasing, causing a significant burden on patients, their families, and society due to their complex pathogenesis, long course, and difficult treatment. Research is focusing on identifying new ideas and methods for treatment, with adipose stem cells potentially playing a key role in wound healing.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Surgery
Jeremy Lynn, Kavitha Ranganathan, Alexandra O. Luby, Kevin M. Urlaub, Alexis Donneys, Noah S. Nelson, Steven R. Buchman
Summary: This study compares the effects of adipose-derived stem cells (ASCs) and bone marrow stromal cells (BMSCs) on irradiated mandibular fracture repair in mice. The results show that ASCs have superior therapeutic efficacy in terms of union rate, vascular morphology, and trend in biomechanical strength compared to BMSCs. The robust vascular response induced by ASCs better recapitulates the sequence and synchronicity of physiological bone healing, improving the reliability of irradiated fracture repair.
ANNALS OF PLASTIC SURGERY
(2022)
Review
Cell Biology
Yang An, Shuyan Lin, Xiaojie Tan, Shiou Zhu, Fangfei Nie, Yonghuan Zhen, Luosha Gu, Chunlei Zhang, Baicheng Wang, Wei Wei, Dong Li, Junhao Wu
Summary: ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling to inhibit scar hyperplasia in wounds. Compared with ADSCs therapeutics, ADSCs-EXOs have high stability, easy storage, immune system non-rejection, homing effect, and easily controlled dosage. In patients with diabetes mellitus, ADSCs-EXOs can improve fat grafting and promote wound healing.
CELL PROLIFERATION
(2021)
Review
Biochemistry & Molecular Biology
Quan-Wen Liu, Qi-Ming Huang, Han-You Wu, Guo-Si-Lang Zuo, Hao-Cheng Gu, Ke-Yu Deng, Hong-Bo Xin
Summary: Stem cell therapy has the potential to repair tissues and improve functional recovery, but faces challenges such as ethical barriers and immune rejection. Human amnion-derived stem cells (hADSCs) show advantages over other stem cells, including high pluripotency and immunomodulatory effects, making them a promising source for cell therapy and regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Frederik Penzien Mamsen, Lea Munthe-Fog, Mikela Karen Mungal Kring, Dominik Duscher, Mikkel Taudorf, Adam J. Katz, Stig-Frederik Trojahn Kolle
Summary: The review highlights the benefits of using scaffolds for ASC delivery, showing improved cell viability, angiogenesis, and wound healing outcomes compared to ASCs alone. The type of scaffold material influences ASC differentiation and therapeutic effects, with natural scaffolds being recommended for fat regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
