Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 15, Issue 28, Pages 3301-3310Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161209789105225
Keywords
Killer inhibitory receptor; human leukocyte antigen; activating receptors; sialoadhesin
Categories
Ask authors/readers for more resources
MHC-specific Natural Killer inhibitory receptors display a conserved and fundamental function in the regulation of NK-mediated cytolysis. Their importance is substantiated by the fact that during speciation different molecular receptor structures have evolved to maintain inhibitory regulation of NK cells. The information gained during these last twenty years begins to be fruitfully used in the therapy of leukemias, but a lot has to be still done. In particular, we need to understand the role of activating KIR and their ligand(s), since their role in the course of different viral diseases is still intriguing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available