Review
Chemistry, Multidisciplinary
Gan Jiang, Chenxuan Wei, Yaoxing Chen, Yingqi Lyu, Jialin Huang, Hongzhuan Chen, Xiaoling Gao
Summary: This passage discusses the process of macropinocytosis, which allows for the internalization of greater quantities of drugs and is a promising avenue for drug delivery. It also introduces various drug delivery systems that utilize macropinocytosis as the primary internalization mechanism. The potential importance of this field lies in its ability to greatly increase the efficiency and specificity of drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Guoxiang Liu, Lina Yang, Guang Chen, Fenghua Xu, Fanghao Yang, Huaxin Yu, Lingne Li, Xiaolei Dong, Jingjing Han, Can Cao, Jingyu Qi, Junzhe Su, Xiaohui Xu, Xiaoxia Li, Bing Li
Summary: In recent years, the development of nanomaterials has led to a new field of cancer therapy focusing on drug delivery systems. These systems, such as drug nanoparticles, offer advantages like easy preparation, high efficiency, low toxicity, and active tumor targeting. Research in this area provides a theoretical basis for the future clinical application of personalized cancer nanomedicine.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Rafael Itzhakov, Hagit Hak, Sudharsan Sadhasivam, Eduard Belausov, Elazar Fallik, Ziv Spiegelman, Edward Sionov, Elena Poverenov
Summary: This work successfully delivers bioactive molecules through designing biocompatible nanogel particles (NGPs) using modified nature-sourced building blocks. NGPs are able to deliver drugs and proteins to plant cells, and can co-deliver multiple biomolecules. Furthermore, NGPs successfully encapsulate amphotericin B and reduce its toxicity.
Review
Pharmacology & Pharmacy
Vijay Mishra, Pallavi Nayak, Nishika Yadav, Manvendra Singh, Murtaza M. Tambuwala, Alaa A. A. Aljabali
Summary: SEDDS is a novel lipid-based technological innovation that can improve the oral bioavailability of drugs with poor water solubility. It offers protection against the harsh gut environment and specific strategies to overcome low bioavailability and solubility issues.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Materials Science, Multidisciplinary
Zhiduan Cai, Haoquan Zhuang, Xiezhao Li, Siyang Liang, Wenjun Luo, Yaoji Yuan, Yuyu Xu, Lin Jin, Guibin Xu
Summary: This study developed a nanofiber system as a drug delivery system for anticancer drugs to inhibit the recurrence and metastasis of renal cell carcinoma. The nanofiber system used two types of diameters and biomaterials as drug carriers, achieving short-term and long-term release of paclitaxel to inhibit renal cancer. The results showed that the system had a lasting inhibitory effect on renal clear cell carcinoma cells.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Leila Mousavifar, Jordan D. Lewicky, Alexis Taponard, Rahul Bagul, Madleen Rivat, Shuay Abdullayev, Alexandrine L. Martel, Nya L. Fraleigh, Arnaldo Nakamura, Frederic J. Veyrier, Hoang-Thanh Le, Rene Roy
Summary: This study reports the chemical synthesis of a novel series of mannosylated neoglycolipids with the goal of further improving on the previous glyconanoparticles. By using a new synthetic method, stable neoglycoliposomes were successfully prepared, and their potential applications in improving cellular uptake and biological activity were explored.
Article
Chemistry, Multidisciplinary
Binbin Chu, Yunmin Yang, Jiali Tang, Bin Song, Yao He, Houyu Wang
Summary: The Trojan nanobacteria system is a novel drug delivery system that allows for higher payloads and better stability by internalizing nanoagents into engineered bacteria. It can specifically target tumor regions and penetrate deep tumor tissues, and destroy them through the combined effects of antitumor protein expression and photothermal properties.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Physical
Jonathan Sampath Franklyne, Ponnusamy Manogaran Gopinath, Amitava Mukherjee, Natarajan Chandrasekaran
Summary: Nanoemulsions of essential oil have potential in targeting microorganisms, particularly viruses, and can be used to enhance current therapeutic options. Research has shown that essential oils have broad-spectrum activity, and the emulsification process can improve their efficacy.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Review
Polymer Science
Brielle Stawicki, Tyler Schacher, Hyunah Cho
Summary: Chemotherapy and radiation are mainstays in cancer treatment globally, but some therapies have limited specificity and cause harsh side effects in patients. Nanogels, as a unique drug delivery system, show promise in the treatment of brain cancer, despite complications such as handling and chemical stability. Ongoing development of nanogels offers a patient-centered approach for managing brain cancer.
Article
Pharmacology & Pharmacy
Greta Frei, Adam Haimhoffer, Eniko Csapo, Krisztina Bodnar, Gabor Vasvari, Daniel Nemes, Istvan Lekli, Alexandra Gyongyosi, Ildiko Bacskay, Palma Feher, Liza Jozsa
Summary: The aim of this study was to formulate topical dosage forms containing curcumin for the treatment of certain inflammatory diseases. Self emulsifying drug delivery systems were used to increase the solubility and bioavailability of curcumin. Creams and gels were formulated using penetration-enhancing surfactants and gelling agents. The results showed that the curcumin-containing preparations were safe for skin application and had antioxidant effects. Animal experiments confirmed the effectiveness of the curcumin-containing topical preparations.
Article
Biochemistry & Molecular Biology
T. S. Anirudhan, V. Manjusha, V. Chithra Sekhar
Summary: The study prepared a nano cellulose-based drug delivery system for effective delivery of curcumin, showing high drug loading capacity and maximum drug release at specific pH levels. In vitro studies demonstrated cytotoxicity towards cancer cells, and further investigations suggest its potential application for targeted delivery and controlled release of CUR in cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Weijiang Yu, Jieze Shen, Chong Ji, Peng Zhang, Hao Chang, Youxiang Wang, Jian Ji
Summary: This study presents a novel micro-needle penetration strategy that utilizes the recovery stress of near-infrared light-triggered shape memory polymers to drive micro-needle insertion with controlled force precision. By adjusting the light intensity, the pre-stretch strain of the shape memory polymer can be predetermined to ensure a safe penetration depth. Using this strategy, precise insertion of micro-needles into the stromal layer of the rabbit cornea was demonstrated, and programmable insertion for multistage and patterned payload delivery was achieved. This proof-of-concept strategy promises remotely controlled and highly precise micro-needle insertion, inspiring further developments in micro-needle-related applications.
MATERIALS HORIZONS
(2023)
Review
Nanoscience & Nanotechnology
Tobias Achu Muluh, Zhuo Chen, Yi Li, Kang Xiong, Jing Jin, ShaoZhi Fu, JingBo Wu
Summary: In recent years, there has been a significant increase in research on abnormal cell growth, particularly focusing on the management, treatment, and prevention of tumor recurrence. Cancer immunotherapy aims to educate the body's defensive system to prevent, control, and eliminate tumor cells, with the use of nanoparticles enhancing its effectiveness. By utilizing nanoparticles for precise delivery of immunotherapies to targeted neoplasms, immunotherapy can be a promising approach for cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Smriti Gupta, Shreyasi Majumdar, Sairam Krishnamurthy
Summary: Bioactive glasses (BAGs) have been widely explored as a multifunctional delivery system for various therapeutic molecules, offering controlled release to target tissues and biological activity. Researchers have noted the obstacles hindering the translation of research findings from the lab to clinical settings.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
NorulNazilah Ab 'lah, Chong Yu Lok Yusuf, Pornchai Rojsitthisak, Tin Wui Wong
Summary: Starch, a polysaccharide, has varying amylose-to-amylopectin ratios depending on its biological sources. Modifying starch composition through genetic engineering or chemical and enzymatic methods can alter its properties for oral drug delivery. These modified starches can sustain drug release, form hydrogels, and protect drug molecules from degradation. The use of modified starches has shown promises for specific and controlled oral drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
