Review
Immunology
Victoria Male, Ashley Moffett
Summary: The presence of granulated lymphocytes known as uNK cells in the human uterine mucosa was first noted in the nineteenth century, but they were identified as a type of NK cell in 1990. Uterine NK cells have been found to be less cytotoxic than their peripheral counterparts. Recent research has identified three subpopulations of uNK cells that cluster separately from peripheral NK cells. This review examines the history of uNK cell research, their interactions with placental cells, their role in placental implantation, and their potential for defending against infection and mediating memory effects.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Immunology
Rene Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kolz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Rene Reitermaier, Adelheid Elbe-Buerger
Summary: Single-cell analyses identified a naive T cell population expressing specific T cell receptors enriched in fetal skin and intestine. These cells may contribute to early skin development and fetal immune defense, showing fundamental differences in immune surveillance between fetal and adult human skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sara Monaci, Federica Coppola, Gaia Giuntini, Rossella Roncoroni, Francesco Acquati, Silvano Sozzani, Fabio Carraro, Antonella Naldini
Summary: Hypoxia enhances the expression and secretion of RNASET2 in dendritic cells, which is associated with survival, autophagy, and apoptosis in DCs. The expression of RNASET2 under hypoxia is regulated by the PI3K/AKT pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Maximilian Kiessler, Ioana Plesca, Ulrich Sommer, Rebekka Wehner, Friederike Wilczkowski, Luise Mueller, Antje Tunger, Xixi Lai, Anke Rentsch, Kenneth Peuker, Sebastian Zeissig, Adrian M. Seifert, Lena Seifert, Juergen Weitz, Michael Bachmann, Martin Bornhaeuser, Daniela Aust, Gustavo Baretton, Marc Schmitz
Summary: The study found that higher densities of tumor-infiltrating pDCs are associated with lower UICC staging, increased progression-free and overall survival in colon cancer patients. A lower number of colon cancer-infiltrating pDCs was independently linked to worse prognosis, while the colocalization of activated pDCs and T cells in tumor stroma and within TLS may contribute to the correlation between higher pDC densities and better prognosis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Maria Teresa Pagano, Katia Fecchi, Marina Pierdominici, Elena Ortona, Daniela Peruzzu
Summary: Silibinin exhibits immunosuppressive activity by inhibiting the maturation and activation of human dendritic cells, suggesting its potential application as an adjuvant therapy for autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Tae Jin Yun, Suzu Igarashi, Haoquan Zhao, Oriana A. Perez, Marcus R. Pereira, Emmanuel Zorn, Yufeng Shen, Felicia Goodrum, Adeeb Rahman, Peter A. Sims, Donna L. Farber, Boris Reizis
Summary: Plasmacytoid dendritic cells (pDCs) can recognize live infected cells and produce a unique antiviral immune response, including high amounts of interferons, prolonged and efficient responses to CMV-infected cells, and activation of natural killer cells. Patients with CMV viremia show activated pDCs and increased circulating IFN-I and IFN-III.
SCIENCE IMMUNOLOGY
(2021)
Article
Microbiology
Leanne C. Helgers, Michel S. Bhoekhan, Dasja Pajkrt, Katja C. Wolthers, Teunis B. H. Geijtenbeek, Adithya Sridhar
Summary: Enterovirus A71 is a causative agent of neurological diseases in young children. Dendritic cells may play a role in the dissemination of the virus, and heparan sulfates and heparin derivatives may be effective in attenuating dissemination.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
IrantzuADD F. B. Perez-Ruiz, Jose-Ignacio Ruiz-Sanz, Maria-Luisa Hernandez, Rosaura Navarro, Marcos Ferrando, Zaloa Larreategui, Maria-Begona Ruiz-Larrea
Summary: This study provided the first evidence of the presence of mRNAs and proteins of the three members of the PON family in human ovarian granulosa cells, with active secretion of PON1 and PON3 by the cells. Additionally, it was discovered that PON2 mainly localized with mitochondria and the subcellular nucleo-cytoplasmic distribution of PON1 was associated with the cell cycle.
Article
Biochemistry & Molecular Biology
Marija Drakul, Sergej Tomic, Marina Bekic, Dusan Mihajlovic, Milos Vasiljevic, Sara Rakocevic, Jelena Dokic, Nikola Popovic, Dejan Bokonjic, Miodrag Colic
Summary: Sitagliptin has an effect on the differentiation and maturation of human dendritic cells, with decreased expression of some immune activity molecules and increased expression of some tolerogenic molecules. Sitagliptin-treated cells have lower ability to stimulate T-cells and suppress certain T-cell responses while enhancing immunoregulatory responses. This effect may be achieved through the inhibition of NF-kB and p38MAPK expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Md Mahmudul Hasan, Sumi Sukumaran Nair, Jacqueline G. O'Leary, LuAnn Thompson-Snipes, Verah Nyarige, Junwen Wang, Walter Park, Mark Stegall, Raymond Heilman, Goran B. Klintmalm, HyeMee Joo, SangKon Oh
Summary: The expression of TIGIT in memory B cells plays a critical role in immune regulation. Regulatory B cells have been shown to modulate the immune system effectively.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
James Davies, Sofia Sirvent, Andres F. Vallejo, Kalum Clayton, Gemma Douilhet, Patrick S. Keeler, Jonathan West, Michael Ardern-Jones, Ben D. MacArthur, Harinder Singh, Marta E. Polak
Summary: This study reveals that human epidermal Langerhans cells exist in multiple maturation states during homeostasis and upregulate antigen presentation genes and immunoregulatory modules upon migration. Migration also enhances the ability of Langerhans cells to prime regulatory T cell responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Durga Reddi, Lydia Durant, David Bernardo, Alistair Noble, Nicholas R. English, Philip Hendy, Graeme C. Clark, Joann L. Prior, Ethel Diane Williamson, Stella C. Knight
Summary: The study demonstrated the in vitro priming of naïve human T cells against heat-killed B. pseudomallei by co-culturing with syngeneic, pulsed dendritic cells. Myeloid DCs showed a major response to B. pseudomallei, contributing significantly to the expression of migration marker CCR7 and secretion of proinflammatory cytokines TNF alpha and IL1 beta. The study suggests that this approach could be used to screen for human cellular response to candidate vaccines and enhance cell-mediated immunity against intracellular pathogens.
Article
Cell Biology
Sara Monaci, Federica Coppola, Daniela Rossi, Gaia Giuntini, Irene Filippi, Giuseppe Marotta, Silvano Sozzani, Fabio Carraro, Antonella Naldini
Summary: Hypoxia-induced autophagy in dendritic cells is regulated by PI3Ks, especially Vps34. The study highlights the role of autophagy in maintaining DC homeostasis and inflammatory response levels.
Article
Gastroenterology & Hepatology
Anna-Lena Muller, Christian Casar, Max Preti, Daria Krzikalla, Cornelia Gottwick, Pia Averhoff, Philip Rosenstiel, Mathias Gelderblom, Marcus Altfeld, Ansgar W. Lohse, Silja Steinmann, Marcial Sebode, Jenny Krause, Dorothee Schwinge, Christoph Schramm, Antonella Carambia, Johannes Herkel
Summary: The study reveals the crucial role of type 2 conventional dendritic cells in orchestrating the inflammatory immune response to bile duct injury in PSC, suggesting them as potential therapeutic targets for PSC treatment.
JOURNAL OF HEPATOLOGY
(2022)
Article
Cell Biology
Sarah L. Harden, Jieliang Zhou, Seley Gharanei, Maria Diniz-da-Costa, Emma S. Lucas, Liang Cui, Keisuke Murakami, Jinling Fang, Qingfeng Chen, Jan J. Brosens, Yie Hou Lee
Summary: Endometrial fibroblasts differentiate into specialized decidual cells to control embryo implantation and create an immune-protective matrix throughout pregnancy. Metabolomics analysis revealed significant differences in metabolite secretion between different decidual cell subpopulations, suggesting potential importance for optimal embryo implantation. Temporal changes in metabolite secretion were comparable between decidualizing perivascular cells and endometrial stromal cells, but different metabolites were secreted across the decidualization time-course.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)