Review
Food Science & Technology
Abdul-Hamid M. Emwas, Nahla Al-Rifai, Kacper Szczepski, Shuruq Alsuhaymi, Saleh Rayyan, Hanan Almahasheer, Mariusz Jaremko, Lorraine Brennan, Joanna Izabela Lachowicz
Summary: The relationship between health and nutrition is closely linked, with poor nutrition potentially leading to various metabolic diseases. Metabolomics, as an emerging field of science, has broad research applications and potential for further advancement.
Review
Cell Biology
Zarina Nauryzgaliyeva, Iphigenie Goux Corredera, Elena Garreta, Nuria Montserrat
Summary: Organoids have the potential to recreate organ-specific microanatomy in vitro, but have shortcomings in terms of reproducibility and overall maturity. To address these challenges, researchers are exploring the relevance of mechanical cues in inducing differentiation of pluripotent stem cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Food Science & Technology
Kim Asseo, Masha Y. Niv
Summary: The study analyzed online reviews of food products to investigate sweetness levels, liking, and ingredients. Approximately 7-16% of reviews mentioned oversweetness, which was generally disliked by consumers. This suggests an opportunity for customized products with reduced sweetness.
Review
Clinical Neurology
Tore Eid
Summary: This article introduces the concept and role of metabolomics, emphasizing its importance and uniqueness in the research of complex diseases such as epilepsy. The challenges and solutions in scientific progress and clinical applications of metabolomics are discussed.
Review
Nutrition & Dietetics
Niv Zmora, Eran Elinav
Summary: The global increase in COVID-19 cases has led to the adoption of social distancing and self-isolation, prompting the promotion of telemedicine by the CDC to reduce healthcare contact. While these changes may cause anxiety and hinder healthy living and seeking medical help, modern technology offers solutions to these issues.
Review
Nutrition & Dietetics
Eriko Shibutami, Toru Takebayashi
Summary: Nutrimetabolomics is an emerging field in nutritional research that aims to understand the interaction between diet and health. Through the development of omics technology, it has identified dietary biomarkers and deepened the understanding of metabolic dynamics. However, further efforts are needed to validate these biomarkers for clinical applications.
Review
Plant Sciences
Matthew P. Reynolds, Janet M. Lewis, Karim Ammar, Bhoja R. Basnet, Leonardo Crespo-Herrera, Jose Crossa, Kanwarpal S. Dhugga, Susanne Dreisigacker, Philomin Juliana, Hannes Karwat, Masahiro Kishii, Margaret R. Krause, Peter Langridge, Azam Lashkari, Suchismita Mondal, Thomas Payne, Diego Pequeno, Francisco Pinto, Carolina Sansaloni, Urs Schulthess, Ravi P. Singh, Kai Sonder, Sivakumar Sukumaran, Wei Xiong, Hans J. Braun
Summary: The review highlights the opportunities for enhancing heat and drought resilience in wheat through innovative breeding technologies, including the use of new tools in genetics and remote sensing, as well as identifying climate resilience traits from global wheat genetic resources. By improving crop design targets, developing field-based screening tools, applying genomic technologies, and advancing next-generation breeding methods, a research pipeline is created to boost heat and drought resilience.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Pharmacology & Pharmacy
Wentao Li, Chongyu Shao, Chang Li, Huifen Zhou, Li Yu, Jiehong Yang, Haitong Wan, Yu He
Summary: Metabolomics, as a growing field in systems biology, holds great promise in identifying biomarkers, understanding mechanisms, and monitoring therapeutic outcomes. This review discusses recent advances in metabolomics and its applications in ischemic stroke, as well as summarizing the developments in Chinese herbal formulations and single cell metabolomics.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Review
Plant Sciences
Seogchan Kang, Rhea Lumactud, Ningxiao Li, Terrence H. Bell, Hye-Seon Kim, Sook-Young Park, Yong-Hwan Lee
Summary: Heavy reliance on synthetic pesticides for crop protection is unsustainable, leading to a need for alternative strategies such as using beneficial microbes. A better understanding of factors influencing the efficacy of microbial agents is crucial for their large-scale application as pesticide alternatives. Research on diverse metabolites associated with plant health-related processes, apart from antibiotics, has not received sufficient attention and could provide valuable insights for developing novel crop protection strategies.
Article
Public, Environmental & Occupational Health
Krista Neumann, Susan M. Mason, Kriszta Farkas, N. Jeanie Santaularia, Jennifer Ahern, Corinne A. Riddell
Summary: This study provides a detailed method for using internet search data to measure epidemiologically relevant exposures or health outcomes. It includes five iterative steps and presents a case study to demonstrate the application of this method.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lorraine Brennan, Baukje de Roos
Summary: Precision nutrition aims to provide personalized dietary advice based on individual genetics, metabolism, and dietary/environmental exposures. Recent advances in omic technologies, particularly metabolomics, offer valuable insights for precision nutrition by capturing information on food intake, bioactive compounds, and the impact of diets on metabolism. Utilizing metabolomic profiles to identify subgroups and incorporating them into prediction models can help understand and predict responses to dietary interventions. However, there are still unanswered questions and the key for the future is to address these and demonstrate the efficacy of precision nutrition in promoting adherence to healthier diets and improving overall health.
Review
Biochemistry & Molecular Biology
Lorraine Brennan, Frank B. Hu, Qi Sun
Summary: Nutritional epidemiology traditionally studies the link between diet and health at a population level, but now it incorporates newer methods like metabolomics to gain better insights. By using biomarkers of food intake and metabolite measurements, limitations of traditional approaches can be addressed, but challenges such as biomarker validation and metabolite identification methods need to be overcome for the full potential of metabolomics to be realized.
Article
Neurosciences
Adele Bubnys, Li-Huei Tsai
Summary: Alzheimer's disease is a devastating neurodegenerative disorder that affects the elderly. Despite numerous studies, the root causes and potential treatments for AD remain to be identified. Cerebral organoid technology has allowed for the modeling of human neurophysiology and disease using patient-derived tissue cultures. Recent advancements in organoids and other three-dimensional cell culture systems have led to the development of robust disease pathology models for both familial and sporadic AD. The future of organoid models will involve incorporating additional cell types and tissues to better understand the disease and optimize treatment strategies.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Nicole Kleinstreuer, Anthony Holmes
Summary: The pharmaceutical industry is working on innovative ways to bridge the translation gap between preclinical and clinical drug development to reduce loss. The preclinical application of human-based microphysiological systems (MPS) helps identify compounds not safe or efficacious in clinical trials, and the use of MPS models in understanding the pathophysiology of SARS-CoV-2 during the COVID-19 pandemic is crucial for developing effective therapeutics. A global working group has been established to coordinate MPS and COVID-19 activities and maximize their impacts on scientific research, human health, and animal welfare.
DRUG DISCOVERY TODAY
(2021)
Article
Food Science & Technology
Katherine M. Livingstone, Omar Ramos-Lopez, Louis Perusse, Hisanori Kato, Jose M. Ordovas, J. Alfredo Martinez
Summary: Precision nutrition is a method that utilizes human variability to design personalized dietary interventions. By integrating various technologies, including nutritional genetics, epigenetics, genomics, metabolomics, and metagenomics, it aims to understand metabolism and human wellbeing for implementing health actions. In recent years, significant progress has been made in these research fields, supporting the development of personalized and precision nutrition interventions. Furthermore, advancements in big data and machine learning have opened up new possibilities for the application of precision nutrition in research, industry, and healthcare.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
