Article
Clinical Neurology
Luciana Mendonca Barbosa, Fernanda da Valerio, Samira Luisa Apostolos Pereira, Valquiria Aparecida da Silva, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Jr, Adriana Bastos Conforto, Leandro Tavares Lucato, Marcelo Delboni Lemos, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study examined the relationships between symptoms and somatosensory profiles in patients with central neuropathic pain (CNP) caused by different types of lesions to the central nervous system. The results suggest that CNP of different etiologies may have different pain descriptors and somatosensory profiles, likely due to differences in lesion locations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Chemistry, Medicinal
Anugeetha Thacheril Mohanan, Sermugapandian Nithya, Yousra Nomier, Dalin A. Hassan, Abdulmajeed M. Jali, Marwa Qadri, Shamna Machanchery
Summary: The incidence of stroke is the main cause of central neuropathic pain. Central post-stroke pain (CPSP) is a type of central pain caused by a vascular lesion in the central nervous system, with somatosensory deficits often occurring on the opposite side of the stroke. It is characterized by continuous or intermittent pain accompanied by sensory abnormalities such as dysesthesia and allodynia.
Article
Neurosciences
Yan Fu, Liting Sun, Fengting Zhu, Wei Xia, Ting Wen, Ruilong Xia, Xin Yu, Dan Xu, Changgeng Peng
Summary: Neuropathic pain caused by spinal cord injury is a long-term disturbance for patients, and the underlying mechanisms are still unclear. This study found that the abnormal expression of Nav1.7 in SDH is associated with NP. Pharmacological studies demonstrated that the blood-brain-barrier permeable Nav1.7 inhibitor GNE-0439 has a significant analgesic effect on NP in SCI mice.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Kazufumi Kubota, Yutaka Kitano, Hidemasa Furue
Summary: This study investigated the expression and function of a(2)d-1 in spinal dorsal horn (SDH) neurons after nerve injury. The researchers found that a(2)d-1 was mainly expressed in excitatory neurons marked by Slc17a6, but not in inhibitory neurons marked by Slc32a1. SDH neuron-specific ablation of Cacna2d1, the gene coding a(2)d-1, alleviated mechanical hypersensitivity following nerve injury. The study also showed that enhanced synaptic transmission in SDH neurons after nerve injury could be decreased by mirogabalin application or SDH neuron-specific ablation of Cacna2d1.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Giuseppe Forte, Valentina Giuffrida, Angelica Scuderi, Mariella Pazzaglia
Summary: Neuropathic pain is a common chronic condition that severely affects patients with spinal cord injuries. Current treatment options are limited, but nanomedicine shows potential for improving therapeutic efficacy. However, its application in treating neuropathic pain following spinal cord injuries still needs further improvement.
Article
Public, Environmental & Occupational Health
Eva Widerstrom-Noga, Kimberly D. Anderson, Linda E. Robayo, Salome Perez, Alberto Martinez-Arizala, Lindsey Calle-Coule, Nicholas P. Cherup, Gabriel E. Fernandez
Summary: Many people with spinal cord injury (SCI) suffer from chronic pain, including neuropathic pain, which is often difficult to treat due to its complex nature. A multimodal approach, involving pharmacological treatments, physical rehabilitation, cognitive training, and pain education, may be the most effective strategy for managing pain in this population. This study developed an educational resource called SeePain, which was evaluated and modified based on stakeholder input, including SCI patients, their loved ones, and healthcare providers. The final resource is a comprehensive guide intended to improve health literacy and enhance communication between SCI patients and their healthcare providers. Future research will validate the effectiveness of SeePain using a large sample of SCI patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
You-You Lv, Han Wang, Hai-Ting Fan, Ting Xu, Wen-Jun Xin, Rui-Xian Guo
Summary: The present study found that SUMOylation of spinal Kir7.1 may contribute to the development of mechanical allodynia in neuropathic pain by decreasing the surface expression of Kir7.1.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Health Care Sciences & Services
William Raffaeli, Giorgio Felzani, Michael Tenti, Luca Greco, Maria Pia D'Eramo, Stefania Proietti, Giovanni Morone
Summary: This study aimed to investigate the effect of NACVAN (R) as an adjuvant treatment to gabapentinoids on pain symptomatology in CNP patients. Preliminary results showed significant reductions in pain intensity, neuropathic symptoms, and evoked pain with NACVAN (R) treatment, while other neuropathic pain dimensions and quality-of-life did not significantly improve.
Article
Clinical Neurology
Mustafa Umut Etli, Caner Sarikaya, Mehmet Resid Onen, Sait Naderi
Summary: This study found that neuropathic pain (NP) may occur in both pre-and postoperative periods in patients with spinal hemangioblastomas. The main factors affecting NP include the proximity of the tumor to the dorsal root entry zone, especially the presence of rostral syrinx.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Renaud Jeffrey-Gauthier, Julien Bouyer, Mathieu Piche, Marie-Pascale Cote, Hugues Leblond
Summary: This study found that musculoskeletal injury may hinder locomotor recovery after SCI, with involvement of microglia in this effect, but without modulation of KCC2 expression.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Medicine, Research & Experimental
Mengmeng Zhou, Qingxiang Zhang, Mingzhu Huo, Huijun Song, Hongen Chang, Jiaojiao Cao, Yuxin Fang, Di Zhang
Summary: Nociceptive signaling responses to painful stimuli are transmitted to the central nervous system (CNS) from the afferent nerves of the periphery. Electroacupuncture (EA) is a widely used pain management strategy that can alleviate neuropathic pain in the CNS. This review discusses the mechanisms and pathways, such as serotonin/norepinephrine, endogenous opioid, endogenous cannabinoid, amino acid neurotransmitter, and purinergic pathways, through which EA can provide analgesic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Zhihao Zhang, Zhijie Zhu, Xiaoshuang Zuo, Xuankang Wang, Cheng Ju, Zhuowen Liang, Kun Li, Jiawei Zhang, Liang Luo, Yangguang Ma, Zhiwen Song, Xin Li, Penghui Li, Huilin Quan, Peipei Huang, Zhou Yao, Ning Yang, Jie Zhou, Zhenzhen Kou, Beiyu Chen, Tan Ding, Zhe Wang, Xueyu Hu
Summary: This study investigated the mechanisms of photobiomodulation (PBM) in relieving neuropathic pain (NP) after spinal cord injury (SCI). It was found that PBM therapy inhibited the activation of microglia and astrocytes, decreased the expression of CXCL10 in glial cells, and mediated the NF-κB signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Jay Karri, Shengai Li, Yen-Ting Chen, Argyrios Stampas, Sheng Li
Summary: Central neuromodulation targeting the Pain Neuromatrix-Central Autonomic Network interface produced parasympathetic changes and pain relief in SCI + NP persons, while increasing pain threshold in AB persons without affecting autonomic function. This suggests different responses to neuromodulation between individuals with spinal cord injury and chronic neuropathic pain and able-bodied controls.
Review
Biochemistry & Molecular Biology
Vinicius Tieppo Francio, Keith F. Polston, Micheal T. Murphy, Jonathan M. Hagedorn, Dawood Sayed
Summary: Since 1967, spinal cord stimulation (SCS) technology has evolved significantly, with the introduction of the 10 kHz SCS system that selectively activates inhibitory interneurons in the dorsal horn. This high-frequency stimulation pattern has demonstrated significant pain control superiority in patients with chronic back pain and neuropathic pain.