Article
Anesthesiology
Anne-Sophie Wattiez, William C. Castonguay, Olivia J. Gaul, Jayme S. Waite, Chantel M. Schmidt, Alyssa S. Reis, Brandon J. Rea, Levi P. Sowers, Coral J. Cintron-Perez, Edwin Vazquez-Rosa, Andrew A. Pieper, Andrew F. Russo
Summary: The study characterized tactile sensory profiles of two nonpenetrating models of posttraumatic headache (PTH). The results showed that repetitive daily injury for 3 days induced more severe phenotypes, offering new insights into patterns of injury that may place patients at a greater risk of developing PTH. The research also provided preclinical support for a pathophysiologic role of calcitonin gene-related peptide in PTH.
Article
Nutrition & Dietetics
Kordula Lang-Illievich, Christoph Klivinyi, Gudrun Rumpold-Seitlinger, Christian Dorn, Helmar Bornemann-Cimenti
Summary: This study aimed to investigate the analgesic mechanisms of Palmitoylethanolamide (PEA) and found that PEA significantly reduced heat pain, prolonged cold pain tolerance, increased pressure pain tolerance and conditioned pain modulation, decreased wind-up ratio and average distance of allodynia, and improved heat pain tolerance.
Article
Clinical Neurology
Javier Diaz-de-Teran, Maria Sastre-Real, Luis Lobato-Perez, Gonzalo Navarro-Fernandez, Ignacio Elizagaray-Garcia, Alfonso Gil-Martinez
Summary: The study found significant differences in allodynia, pain catastrophism, and impact between the cluster headache group and the control group. There was a significant relationship between psychological comorbidity, pain catastrophism, and quality of life in cluster headache patients. Anxiety and HIT-6 were predictors of pain catastrophism.
NEUROLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Nasim Maleki, Edina Szabo, Lino Becerra, Eric Moulton, Steven J. Scrivani, Rami Burstein, David Borsook
Summary: This study utilized functional neuroimaging to investigate the differences in brain activation of patients with episodic migraine based on their allodynic status. Differences were found in brain activity in various regions between the ictal and interictal visits, with notable differences along the trigeminal pathway in patients with generalized allodynia. These findings indicate hyper-responsiveness in certain brain regions in migraine patients experiencing allodynia during attacks.
Review
Clinical Neurology
Keisuke Suzuki, Shiho Suzuki, Tomohiko Shiina, Saro Kobayashi, Koichi Hirata
Summary: This article reviewed the association between central sensitization (CS) and migraine, emphasizing the role of CS in the pathogenesis of chronic migraine. The importance of appropriate screening and management of CS in improving the quality of life for migraine patients was highlighted.
JOURNAL OF PAIN RESEARCH
(2022)
Review
Anesthesiology
Grace Simpson, Moira Philip, Tarana Lucky, Catarina Ang, Shamitha Kathurusinghe
Summary: Central sensitization contributes to patient variability in treating pain in endometriosis. This review aims to summarize the findings of studies regarding targeted treatments for central sensitization. The limited research suggests that surgery and nerve stimulation may be the most promising treatments.
CLINICAL JOURNAL OF PAIN
(2022)
Article
Clinical Neurology
Daigo Ikegami, Edita Navratilova, Xu Yue, Aubin Moutal, Caroline M. Kopruszinski, Rajesh Khanna, Amol Patwardhan, David W. Dodick, Frank Porreca
Summary: The study revealed a sexually dimorphic mechanism of migraine progression involving down-regulation of PRLR-L and increased signaling of circulating prolactin at PRLR-S. These findings suggest potential for novel sex-specific therapies, such as gene editing through nasal delivery of CRISPR/Cas9 constructs, to target migraine pain specifically in females.
Article
Clinical Neurology
Melissa M. Cortez, Leah Millsap, Natalie A. Rea, Christopher Sciarretta, K. C. Brennan
Summary: The study found that a high percentage of persistent post-traumatic headache subjects exhibited both light and tactile sensitivity, which was associated with higher headache frequencies and lower sensitivity thresholds. This suggests that hypersensitivity across multiple modalities may be functionally synergistic and reflect a higher disease burden.
Article
Immunology
Yan-Yan Zhang, Fei Liu, Zhong-Han Fang, Yue-Ling Li, Hong-Lin Liao, Qin-Xuan Song, Cheng Zhou, Jie-Fei Shen
Summary: This study demonstrates the important roles of the spinal N-methyl-D-aspartate receptor (NMDAR) subtypes NR2A and NR2B in orofacial pain. The differential actions of NR2A and NR2B in mediating peripheral and central sensitization were observed, providing insights into the neural mechanisms' reaction to nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Editorial Material
Clinical Neurology
Daniel N. Lax, Marielle Kabbouche, Joanne Kacperski, Andrew D. Hershey
Summary: This study discusses the importance of recognizing primary headache disorders other than migraines in children and adolescents. It presents a case of an adolescent with two different headache phenotypes and provides a guided discussion on differential diagnoses, workup, treatments, and further management considerations.
Article
Neurosciences
Jixiang Zhang, Jazzmine M. Junigan, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen, Peter M. Grace
Summary: The treatment with an HDAC6 inhibitor can reverse cisplatin-induced mechanical hypersensitivity by inducing tonic enkephalin-DOR signaling in peripheral sensory neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Toshihide Toriyama, Yoshiki Hanaoka, Tetsuyoshi Horiuchi
Summary: This study aimed to elucidate the clinical features of patients with vestibular migraine (VM) and evaluated the association of cutaneous allodynia in VM patients. It found that VM patients had significantly higher prevalence of widespread multimodal cutaneous allodynia compared to episodic migraine patients without vestibular symptoms. Additionally, the VM group exhibited characteristics such as aura, severe disability, depression, tinnitus, and sleep disorders.
ACTA NEUROLOGICA BELGICA
(2022)
Article
Neurosciences
Yanyun Wang, Liang Dong, Yun Zhang, Yixin Zhang, Guangcheng Qin, Dunke Zhang, Lixue Chen, Wei He, Jiying Zhou
Summary: Excessive use of headache treatments can lead to the development, progression, and exacerbation of medication overuse headache (MOH), characterized by central sensitization. This study investigates the impact of microglial activation and the P2X7R/NLRP3 signaling pathway on the pathogenesis of MOH. The results suggest that inhibiting microglial activation can reduce central sensitization caused by chronic treatment and may be a potential strategy for managing MOH.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Richard B. Lipton, David W. Dodick, Peter J. Goadsby, Rami Burstein, Aubrey M. Adams, Jeff Lai, Sung Yun Yu, Michelle Finnegan, Amy W. Kuang, Joel M. Trugman
Summary: This study aimed to compare the efficacy of ubrogepant in treating migraine with mild vs moderate or severe pain. The results showed that ubrogepant treatment during mild pain significantly increased the rates of pain freedom, freedom from associated symptoms, and achieving normal function.
Article
Chemistry, Analytical
Noy Turgeman Dahan, Jean-Jacques Vatine, Irit Weissman-Fogel, Hana Karpin, Sharon Shmuely, Tami Bar-Shalita
Summary: This study developed a reliable and valid protocol called Quantitative Dynamic Allodynography (QDA) for measuring Dynamic Mechanical Allodynia (DMA) in a clinical setting. The QDA showed high test-retest and inter-rater reliability, and correlated with other measures of pain and quality of life.
