Article
Rheumatology
Alyssa Wohlfahrt, Lutfiyya N. Muhammad, Jing Song, Dorothy D. Dunlop, Tuhina Neogi, Clifton O. Bingham III, Marcy B. Bolster, Wendy Marder, Daniel J. Clauw, Yvonne C. Lee
Summary: This study used regression tree methodology to determine the mechanisms most predictive of disease activity after DMARD treatment. The results showed that lower knee pressure pain thresholds were the strongest predictor of higher posttreatment disease activity in patients with low/moderate disease activity. In patients with high baseline disease activity, less efficient descending pain modulation was the strongest predictor of higher posttreatment disease activity.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Noha F. Mahmoud, Howida A. Fouda, Islam I. Omara, Nashwa M. Allam
Summary: This study investigated the effects of Siwan traditional therapy on central sensitization, pain severity, pain threshold, and kinesiophobia in patients with RA. The results showed that Siwan traditional therapy significantly improved pain severity, pain threshold, and kinesiophobia. However, there was no significant difference between different exposure times, indicating the need for further long-term studies to determine its long-term efficacy.
Article
Biochemistry & Molecular Biology
Chun-Rui Yang, Hong-Jun Ding, Miao Yu, Fiona-H Zhou, Chen-Yang Han, Rui Liang, Xiao-Yang Zhang, Xiang-Lian Zhang, Fan-Jie Meng, Shuo Wang, De-Dong Li, Wei-Zong Sun, Bin Meng, Xin-Fu Zhou
Summary: The proBDNF/p75NTR signaling pathway plays an important role in inflammatory arthritis pain and rheumatoid arthritis (RA). The expression levels of p75NTR and proBDNF are significantly increased in RA patients compared to healthy donors, and they are positively correlated with Disease Activity Score. In a mouse model, blocking the pathway with p75ECD-Fc effectively blocks inflammatory responses and relieves pain.
Article
Rheumatology
Jennifer L. Beaumont, Elizabeth S. Davis, Jeffrey R. Curtis, David Cella, Huifeng Yun
Summary: The study estimated meaningful change thresholds for fatigue and pain interference in rheumatoid arthritis patients, finding the MCT range to be 1-2 points and showing low correlations between change scores and retrospective ratings.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Rheumatology
Yvonne Tan, Maya H. Buch
Summary: This review summarises the key concepts of difficult to treat rheumatoid arthritis (D2T-RA) defined by the European Alliance of Associations for Rheumatology. D2T-RA is primarily characterized by the failure of at least two different mechanism of action drugs with evidence of active/progressive disease. The review suggests additional considerations in the definition of D2T-RA and the potential value of identifying D2T traits and intervening before the development of D2T-RA state.
Article
Multidisciplinary Sciences
Eithne Nic An Rioghid, Eimear Dunne, Sharon Cowley, Kelly Leamy, Geraldine McCarthy, Dermot Kenny, John Stack
Summary: Clinical improvement in patients with inflammatory arthritis is associated with changes in platelet function, suggesting that an appropriate assay of platelet function could guide therapy for these patients.
Article
Environmental Sciences
Guangwen Zhang, Baojian Liu, Zhaoyang Zeng, Qinghai Chen, Yiyun Feng, Xueqian Ning
Summary: OMTH effectively inhibited TNF-alpha-mediated increased viability of RA synovial cells and activated apoptosis, while reducing MEK/1/2 and p65 phosphorylation in a dose-based manner. Therefore, OMTH may act as a potential therapeutic agent for RA treatment.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Rheumatology
Ketian Li, Wenxiu Mo, Lijun Wu, Xunyao Wu, Cainan Luo, Xinyue Xiao, Xinmiao Jia, Huaxia Yang, Yunyun Fei, Hua Chen, Fengchun Zhang, Yongzhe Li, Lidan Zhao, Xuan Zhang
Summary: This study identified nine novel autoantibodies in ACPA-negative RA, with anti-PTX3 and anti-DUSP11 showing the highest sensitivity. The combination of these two autoantibodies significantly increased the diagnostic sensitivity in ACPA-negative RA. The novel biomarkers provide potential diagnostic value for ACPA-negative RA patients.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Feng Gao, Ziqi Dai, Tong Zhang, Yuhao Gu, Desheng Cai, Mingjun Lu, Zijie Zhang, Qi Zeng, Bingxian Shang, Bing Xu, Haimin Lei
Summary: In this study, a series of novel sinomenine derivatives were designed and synthesized. Compound 17 exhibited excellent anti-inflammatory and analgesic activities, indicating its potential as a drug.
Article
Immunology
Piercarlo Sarzi-Puttini, Margherita Zen, Federico Arru, Valeria Giorgi, Ernest A. Choy
Summary: Pain is a significant issue in rheumatoid arthritis (RA), and inflammation, neuroendocrine responses, cytokines, and the JAK-STAT pathway play a role in its development. Residual pain may persist even after achieving remission, potentially involving non-inflammatory mechanisms and central sensitization. Fibromyalgia syndrome (FMS) is prevalent in RA patients and needs to be identified and diagnosed. JAK inhibitors have shown pain-reducing effects in RA patients independently of their anti-inflammatory properties.
AUTOIMMUNITY REVIEWS
(2023)
Article
Chemistry, Analytical
Peng Wu, Hu Xiong
Summary: In this study, a fluorescent probe PPS was developed for the detection of excessive hypochlorite acid (HClO) in the microenvironment of rheumatoid arthritis (RA). The probe showed good solubility and fast response to HClO, and its fluorescence intensity could be further enhanced under acidic conditions. Moreover, it could sensitively detect both exogenous and endogenous HClO and visualize endogenous HClO generation in a RA mouse model.
Review
Immunology
Yuan Qu, Yang Fu, Yuan Liu, Chuanguo Liu, Bing Xu, Qian Zhang, Ping Jiang
Summary: Transient receptor potential cation channel subfamily V member 1 (TRPV1) has been found to play a role in immune regulation and its dysregulation affects the development of rheumatoid arthritis. Understanding the mechanism of TRPV1 can lead to the design of new drugs and improved treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Marie-Astrid Boutet, Gabriel Courties, Alessandra Nerviani, Benoit Le Goff, Florence Apparailly, Costantino Pitzalis, Frederic Blanchard
Summary: Macrophages play a critical role in the pathogenesis and treatment of rheumatoid arthritis, advancements in high-throughput technologies have expanded the understanding of synovial cell diversity and potential therapeutic targets.
AUTOIMMUNITY REVIEWS
(2021)
Article
Immunology
Yan Liu, Michael J. Caterina, Lintao Qu
Summary: Persistent arthritis pain after resolution of joint inflammation is a significant problem in patients with rheumatoid arthritis (RA). This study suggests that sensory neuron expressed Fc gamma RI may play a role in postinflammatory arthritis pain. Deletion of Fcgr1 can alleviate mechanical hyperalgesia in a mouse model of collagen antibody-induced arthritis. Neuroinflammation within the dorsal root ganglion (DRG) may upregulate Fc gamma RI signaling in DRG neurons. Sensory neuron expressed Fc gamma RI is a potential target for the treatment of arthritis pain that persists in RA patients in remission.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Deeba Minhas, Anne Murphy, Daniel J. Clauw
Summary: This review highlights the frequent coexistence of fibromyalgia and augmented central nervous system processing in individuals with rheumatoid arthritis (RA), which may contribute to persistent pain. IL-6 and Janus kinase inhibitors, in addition to targeting peripheral inflammation, may provide pain relief by acting on both peripheral and central pain pathways.
CURRENT OPINION IN RHEUMATOLOGY
(2023)