Journal
CURRENT ORGANIC CHEMISTRY
Volume 18, Issue 4, Pages 489-511Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/13852728113176660149
Keywords
Asymmetric conjugation; C-C bond formation; chiral reagent; chiral catalyst; enolizable carbonyl derivatives; Michael addition
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Funding
- Alzahra University Research Council
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Attempts to induce stereoselectivity in the conjugate addition to the alpha, beta-unsaturated acceptors have been investigated by numerous research groups, classically through the use of either a chiral acceptor or chiral donor component in the reaction. The asymmetric Michael addition catalyzed by chiral catalysts has been extensively proven and established to be a powerful synthetic tool for especially a range of asymmetric syntheses of natural products and various heterocyclic systems. This review covers the recent reports and further applications of this methodology in the formation of carbon-carbon bond between or within functionalized and sensitive substrates which provides new opportunities, mainly in the total synthesis, medicinal and process chemistry, nanotechnology and chemical biology.
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