Article
Agricultural Engineering
Chao-Ran Li, Liu-Xiu Yang, Zi-Fan Guo, Hua Yang, Ying Zhang, You-Mei Wang, Guan-Zhong Zhang, Ping Li, Wen Gao
Summary: In this study, an untargeted metabolomics strategy was used to analyze the metabolome differences in Cannabis leaves collected from different provinces, revealing specific flavonoids and cannabinoids. Flavonoid glucuronides were more abundant in leaves from Xinjiang and Qinghai, while flavonoid glycosides were more prevalent in those from Sichuan.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Kexin Song, Qingya Duan, Jiping Ren, Jie Yi, Hong Yu, Haixia Che, Chunjuan Yang, Xiaotong Wang, Qian Li
Summary: Luteolin reverses pulmonary vascular remodeling in PAH by inhibiting abnormal cell proliferation and regulates multiple metabolic pathways.
Review
Biochemistry & Molecular Biology
Adele Chimento, Arianna De Luca, Maria D'Amico, Francesca De Amicis, Vincenzo Pezzi
Summary: Various literature data suggest that a diet rich in vegetables can reduce the incidence of cancer by utilizing the natural polyphenols present in them. Polyphenols possess various pharmacological actions such as anti-inflammatory, anti-oxidant, antibiotic, antiseptic, anti-allergic, cardioprotective, and even anti-tumor properties. The anti-tumor action of polyphenols involves multiple mechanisms associated with cell proliferation, differentiation, migration, angiogenesis, metastasis, and cell death. This review aims to provide an updated understanding of the apoptotic molecular mechanisms induced by representative polyphenols in cancer cells, which can be utilized in the development of new therapeutic strategies against cancer involving polyphenols as adjuvants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Dmitri Stepanov, David Buchmann, Nadin Schultze, Gerhard Wolber, Katharina Schaufler, Sebastian Guenther, Vitaly Belik
Summary: Screening for biofilm inhibition by purified natural compounds is challenging due to their chemical diversity and limited availability. In this study, researchers performed experimental assessment of antibiofilm activity of 320 phenolic natural compounds and trained a predictive model for biofilm inhibition. The model achieved a high accuracy in predicting the targeted effect and significantly improved the discovery rate of active phenolic compounds when compared to random selection.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Yao Hu, Chaojun Guo, Qianzhu Lin, Jiali Hu, Xiaojing Li, Shangyuan Sang, David Julian McClements, Jie Long, Zhengyu Jin, Jinpeng Wang, Chao Qiu
Summary: This study explored the potential of a cyclodextrin derivative, SACD, to improve the bioaccessibility of curcumin. The results showed that SACD significantly increased the water dispersibility of curcumin and enhanced its binding to plasma proteins, while reducing its ability to induce protein conformational changes.
Article
Chemistry, Multidisciplinary
Yi Du, Iman Korchi, Aleksandr E. Rubtsov, Andrei V. Malkov
Summary: In this study, we propose an expedient method to introduce terpene fragments into the aromatic rings of natural stilbenoids and flavonoids, enhancing their therapeutic potential.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Pooja Negi, Nishant Pandey, Tripti Mishra, Vivek Ahluwalia, Umesh Singh, Bhuwan B. B. Mishra
Summary: This study aimed to extract a natural dye from the flower petals of Butea monosperma using an eco-friendly and organic solvent-free approach. The hot aqueous extraction of dry B. monosperma flowers resulted in an orange-colored dye with a yield of around 35%. Three marker compounds were isolated from the dye powder and characterized using various spectroscopic methods. The dye powder and isolated compounds showed excellent stability up to 200°C.
Article
Chemistry, Multidisciplinary
Kai Xia, Wei-Jin Qi, Xiao-Qiang Wu, Yu-Yang Song, Jun-Jie Zhu, Yi Ai, Zhen Cui, Zheng-Ping Zhang, Shu-Ai Tang, Yu-Ting Gui, Yue Yuan, Lu Wang, Hang Zhong
Summary: Blumeatin, isolated from Blumea balsamifera, is a compound with hydroxyl groups at C3' and C5' of ring B. However, the traditional isolation procedure for blumeatin is time-consuming and costly. This study presents a new method for efficient preparation of optically pure blumeatin and its R-isomer through Lewis acid-catalyzed ring closure and chiral resolution via Schiff base intermediates. Moreover, a structure revision of putative blumeatin based on logical synthesis and NMR spectroscopic analysis suggests that the reported blumeatin structure is misassigned as sterubin. Ear-swelling test results demonstrate that synthetic (+/-)-blumeatin and (+/-)-sterubin show moderate anti-inflammatory activity, which is lower than that of (-)-sterubin.
Review
Food Science & Technology
Abid Naeem, Yang Ming, Hu Pengyi, Kang Yong Jie, Liu Yali, Haiyan Zhang, Xiao Shuai, Wenjing Li, Wu Ling, Zhang Ming Xia, Liu Shan Shan, Zheng Qin
Summary: Despite advances in synthetic chemistry, nature remains the primary source of drug discovery. Flavonoids have shown significant therapeutic activities, yet they face absorption disorders leading to low bioavailability. Further investigation is needed to understand these interactions and enhance their effectiveness in clinical applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Yanqing Yang, Lianzhu Lin, Mouming Zhao, Xinyi Yang
Summary: In this study, Moringa oleifera leaf flavonoids (MOLF) with strong alpha-glucosidase inhibitory activity and MOL polysaccharides (MOLP) with strong cholic acid-binding capacity were prepared and mixed for the development of MOL highly-processed products with hypoglycemic and hypolipemic potentials. The main components of MOLF were identified as quercetin-3-O-glucoside and kaempferol-3-O-glucoside. MOLP composed of galactose, arabinose, rhamnose, and galacturonic acid showed the strongest effects on regulating carbohydrate and lipid digestion and absorption. MOLF and MOLP had a synergistic effect on delaying glucose diffusion and dialysis, delaying starch digestion, and binding bile acids.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Jiang Shi, Jesus Simal-Gandara, Jufen Mei, Wanjun Ma, Qunhua Peng, Yali Shi, Qi Xu, Zhi Lin, Haipeng Lv
Summary: Tea cultivars with purple shoots have drawn global attention. A study comparing purple-coloured tea leaves with green-coloured tea leaves found differences in anthocyanins, flavonoids, and other compounds, with the former containing higher levels of certain compounds. This suggests that modified anthocyanins and co-pigmented flavonoids are primarily responsible for the purple colouration of the tea leaves.
Article
Chemistry, Multidisciplinary
Kai Xia, Wei-Jin Qi, Xiao-Qiang Wu, Yu-Yang Song, Jun-Jie Zhu, Yi Ai, Zhen Cui, Zheng-Ping Zhang, Shu-Ai Tang, Yu-Ting Gui, Yue Yuan, Lu Wang, Hang Zhong
Summary: Blumeatin, isolated from Blumea balsamifera, a traditional Chinese medicine, possesses two hydroxyl groups at C3' and C5' of ring B. However, the current isolation method for blumeatin from plants is time-consuming and expensive. In this study, a Lewis acid-catalyzed ring closure and chiral resolution procedure utilizing Schiff base intermediates was developed for the efficient preparation of optically pure blumeatin and its R-isomer. Furthermore, a structure revision of putative blumeatin was conducted based on a logically synthetic procedure and NMR spectroscopic analysis, which revealed that the reported blumeatin structure corresponds to sterubin instead. The synthetic (+/-)-blumeatin and (+/-)-sterubin exhibited moderate anti-inflammatory activity, though lower than that of (-)-sterubin, as demonstrated by the ear-swelling test.
Article
Biochemistry & Molecular Biology
Masayuki Yamaga, Hiroko Tani, Miyu Nishikawa, Keisuke Fukaya, Shin-ichi Ikushiro, Kaeko Murota
Summary: This study investigated the pharmacokinetics and metabolism of Brazilian green propolis (BGP) components in humans, revealing that artepillin C and drupanin were the main substances with high concentrations in plasma, most of which were phenolic glucuronide conjugates. These findings provide valuable insights for further research on the mechanisms and pharmacological effects of BGP.
Article
Biochemistry & Molecular Biology
Qinge Ma, Yang Guan, Zhipei Sang, Jianghong Dong, Rongrui Wei
Summary: This study isolated several compounds with hepatoprotective and hypolipidemic properties from the fruits of Hippophae rhamnoides L. using a bioassay-guided approach. The structures and activities of these compounds were extensively analyzed and discussed.
Editorial Material
Food Science & Technology
Hubert Wojtasek
Summary: The article describes Quercetin as an inhibitor of tyrosinase, but previous literature has firmly established it as a substrate of the enzyme and an antioxidant that reduces tyrosinase-generated o-quinones.
FOOD RESEARCH INTERNATIONAL
(2022)
