Designer three-dimensional DNA architectures

The capability to de novo design molecular structures with precise weights, geometries, and functions provides an important avenue not only for scientific explorations, but also for technological applications. Owing largely to its rationalizable design strategies, super-molecular self-assembly with DNA has emerged as a powerful approach to assemble custom-shaped intricate three-dimensional nanostructures with molecular weights up to several megadaltons. Here, we summarize and discuss landmark achievements and important methodologies in three-dimensional DNA nanostructures.