Review
Chemistry, Medicinal
Noujoud Gabed, Frederic Verret, Aurelie Peticca, Igor Kryvoruchko, Romain Gastineau, Orlane Bosson, Julie Seveno, Olga Davidovich, Nikolai Davidovich, Andrzej Witkowski, Jon Bent Kristoffersen, Amel Benali, Efstathia Ioannou, Aikaterini Koutsaviti, Vassilios Roussis, Helene Gateau, Suliya Phimmaha, Vincent Leignel, Myriam Badawi, Feriel Khiar, Nellie Francezon, Mostefa Fodil, Pamela Pasetto, Jean-Luc Mouget
Summary: The marine pennate diatom Haslea ostrearia, known for its blue pigment marennine, has potential applications in various industries. The discovery of a new blue Haslea species revealed previously unknown biodiversity. This study advocates for establishing H. ostrearia as a new model organism, highlighting its advantages and the challenges involved.
Review
Chemistry, Multidisciplinary
Jae Seong Lee, Gao-Feng Han, Jong-Beom Baek
Summary: Hydrogen, as a clean energy source and alternative to fossil fuels, has the potential to significantly reduce carbon emissions. However, the transportation and storage of hydrogen pose significant challenges for realizing a hydrogen economy. Ammonia, with its high hydrogen content and easy liquefaction, is considered a promising hydrogen carrier. The traditional method of ammonia production, the thermocatalytic Haber-Bosch process, requires high temperature and pressure, limiting its production to centralized systems. Mechanochemical ammonia synthesis offers an alternative method under near ambient conditions, connecting with localized sustainable energy systems. This perspective introduces the state-of-the-art mechanochemical ammonia synthesis processes and discusses the challenges and opportunities it presents for a hydrogen economy.
Article
Biochemistry & Molecular Biology
Jon M. Fukuto
Summary: Hydrogen sulfide (H2S) plays a significant role in various physiological processes and is closely related biochemically to hydropersulfides (RSSH). Recent studies suggest that RSSH may interact with H2S in biological systems, providing new insights into the chemical biology of RSSH. The future direction of research will focus on determining the relevance of RSSH chemical biology to signaling and cellular physiology.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Gastroenterology & Hepatology
Gregory S. Sayuk, Jan Tack
Summary: Irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) have a significant impact on the quality of life of affected individuals. Tegaserod, a 5-HT4 agonist, was approved for the management of IBS-C and CIC but was later withdrawn due to concerns about adverse cardiovascular events. After generating additional safety data and undergoing a review, tegaserod was re-approved for use in IBS-C with restricted labeling. This review summarizes the regulatory journey and provides an overview of the pharmacokinetic, physiologic, clinical, and safety data of tegaserod.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Plant Sciences
Irina O. Averkina, Muhammad Harris, Edward Ohene Asare, Berenice Hourdin, Ivan A. Paponov, Cathrine Lillo
Summary: The study found that the expression of the PP2A protein phosphatase B' gene in tomato roots is strongly influenced by beneficial microbes, while the B'f gene is expressed at low levels under all conditions and at a lower level compared to other subunits.
Review
Plant Sciences
Herve Sauquet, Santiago Ramirez-Barahona, Susana Magallon
Summary: The origin of flowering plants has been a transformative event in the history of the Earth, but the age of the group remains uncertain. Recent studies have provided conflicting estimates for the crown-group age of angiosperms. This study clarifies and distinguishes the different ages of angiosperms and argues that fossil-calibrated molecular dating estimates are mainly influenced by prior distribution. Future discoveries and novel analyses are needed for more definitive answers.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Heather L. Winter, Laura Flores-Bocanegra, Kristof B. Cank, William J. Crandall, Fridah C. Rotich, Madeline N. Tillman, Daniel A. Todd, Tyler N. Graf, Huzefa A. Raja, Cedric J. Pearce, Nicholas H. Oberlies, Nadja B. Cech
Summary: Due to resistance, Acinetobacter baumannii is a top priority for drug development according to the World Health Organization. A library of extracts from 2500 fungi was screened for antimicrobial activity against a drug-resistant strain of A. baumannii, and an extract from the fungus Tolypocladium sp. was found to be the most potent. The extract produced pyridoxatin, which may serve as a lead compound for the development of antimicrobials against A. baumannii.
PHYTOCHEMISTRY LETTERS
(2023)
Editorial Material
Biochemical Research Methods
Jimmy K. Guo, Mitchell Guttman
Summary: The number of annotated noncoding RNAs and RNA-binding proteins has significantly increased in recent years. While the wide range of RNA-binding proteins identified suggests a vast potential for RNA in cell biology, the functional importance of these interactions remains to be fully demonstrated, highlighting the need for further exploration and research.
Review
Endocrinology & Metabolism
Azza A. H. Rajab, Wael A. H. Hegazy
Summary: Diabetes is a chronic disease that is considered one of the most stubborn global health problems. It continues to grow in prevalence, leading to an increase in diabetes complications and healthcare costs worldwide. One major complication is the high susceptibility to infections, especially in the lower limbs, due to the weakened immune system of diabetic patients.
WORLD JOURNAL OF DIABETES
(2023)
Review
Plant Sciences
Muhammad Ahmad, Muhammad Imtiaz, Muhammad Shoib Nawaz, Fathia Mubeen, Asma Imran
Summary: Temperature is a crucial factor in agriculture, and global warming has posed a serious threat to agricultural production. An increase in temperature negatively affects different stages of plant development, leading to yield losses. Plants respond to heat stress through adaptation and tolerance strategies. Utilizing plant growth-promoting rhizobacteria (PGPR) can enhance plant heat stress tolerance.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Hematology
Keith R. McCrae, Shadi Swaidani, C. Marcela Diaz-Montero, Alok A. Khorana
Summary: Cancer immunotherapy, particularly treatment with immune checkpoint inhibitors (ICI), has become a significant new approach for cancer treatment. However, the occurrence of ICI-Associated Thrombosis (IAT) has become a major clinical concern. The mechanisms of IAT are not well understood but may involve the activation of blood and vascular cells leading to thromboinflammation. Elevated levels of myeloid derived suppressor cells and inflammatory cytokines may serve as biomarkers of IAT.
THROMBOSIS RESEARCH
(2022)
Review
Plant Sciences
Paulo G. Hofstatter, Gokilavani Thangavel, Marco Castellani, Andre Marques
Summary: Holocentric chromosomes are different from the common monocentric organization, with multiple centromeric regions along their length. They have evolved independently in animal and plant lineages, and can correctly segregate broken chromosome parts. However, adaptations are needed to deal with the consequences of holocentricity on nuclear processes.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Health Care Sciences & Services
Pablo Cuesta-Montero, Jose Navarro-Martinez, Melina Yedro, Maria Galiana-Ivars
Summary: Clinical simulation is an effective tool in sepsis education and training, improving knowledge and skills. Different simulation methods can be utilized, with proven effectiveness and positive impact on patient outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Rheumatology
Yuliya Afinogenova, Abhijeet Danve, Tuhina Neogi
Summary: This review discusses recent advances in the epidemiology and treatment strategies for gout, including genetic factors, obesity, dietary factors, and drug therapies. Despite some progress in gout management, there is still a substantial need for improvement and increased education for patients and clinicians.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Plant Sciences
Takeshi Izawa
Summary: Using Arabidopsis thaliana as a model system has revealed various molecular mechanisms controlling flowering, including photoperiod, vernalization, autonomous, and gibberellin pathways. Recent studies suggest stress signals may be regulated by hormonal control of flowering. Comparing the rice flowering pathway with that of Arabidopsis thaliana has provided insights into the diversity of molecular mechanisms in plant species.
