Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 20, Issue 3, Pages 351-359Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.04.002
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Funding
- NIH, [GM079656, GM066099]
- NSF [DBI-0547695, CCF 0905536]
- National Library of Medicine (NLM) [5T15LM07093]
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [0905536] Funding Source: National Science Foundation
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Protein interactions give rise to networks that control cell fate in health and disease; selective means to probe these interactions are therefore of wide interest. We discuss here Evolutionary Tracing (ET), a comparative method to identify protein functional sites and to guide experiments that selectively block, recode, or mimic their amino acid determinants. These studies suggest, in principle, a scalable approach to perturb individual links in protein networks.
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