Review
Rheumatology
Fabio Massimo Perrotta, Rik Lories, Ennio Lubrano
Summary: Recent research has highlighted the significance of biomechanical stress and microdamage in the pathogenesis of inflammatory arthritis, particularly axial spondyloarthritis. Rehabilitation and exercise programs are crucial in treating axSpA, reducing disease activity and improving quality of life. The concept of mechanical stress as a contributor to disease development and progression presents a conceptual challenge and may have paradoxical effects.
Article
Rheumatology
Shao-Hsien Liu, Divya Shridharmurthy, Kate L. Lapane, Catherine E. Dube, Ellen M. Gravallese, Jonathan Kay
Summary: Most participants in the study, regardless of axial or peripheral spondyloarthritis, were well-educated non-Hispanic White men, with about 40% meeting US Department of Health and Human Services physical activity recommendations. While attitudes and beliefs towards exercise were similar among different disease types, those with axial disease showed greater concerns regarding discomfort and joint injuries. Participants with axial spondyloarthritis spent less time in light and moderate activities compared to those with peripheral disease.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Health Care Sciences & Services
Luca Pontone Gravaldi, Francesca Bonetti, Simona Lezzerini, Fernando De Maio
Summary: This study evaluated the safety and effectiveness of non-pharmacological interventions supervised by a physiotherapist in patients with Ankylosing Spondylitis. The meta-analysis results showed that supervised physiotherapy was associated with significant improvements in disease activity and functional capacity compared to usual care, but no significant differences were found when compared to home-based exercise programmes. Further investigation and larger-scale RCTs are needed to confirm these findings.
Article
Rheumatology
Elif Gur Kabul, Bilge Basakci Calik, Mucahit Oztop, Veli Cobankara
Summary: The study showed that soft-tissue mobilization therapy in addition to exercises can significantly improve symptoms and functional level in AS patients, compared to those who only received exercises. However, the control group showed significant deterioration in BASMI score.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Sai Ma, Liang Zhang, Siliang Man, Tao Bian, Hongchao Li, Weiyi Li, Zhuyi Ma, Da He
Summary: Chinese outpatients with ankylosing spondylitis (AS) have poor adherence to exercise therapy, and current use of nonsteroidal anti-inflammatory drugs (NSAIDs) is the main contributing factor.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Anne-Kathrin Rausch, Philipp Baltisberger, Andre Meichtry, Beatrice Topalidis, Adrian Ciurea, Theodora P. M. Vliet Vlieland, Karin Niedermann
Summary: This study adapted the core strength endurance test battery (aCSE) for patients with axial spondylarthritis (axSpA) and found it to be a reliable tool for assessing core strength endurance. Interestingly, no associations were found between aCSE performance and disease-specific factors.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
James Cheng-Chung Wei, Tae-Hwan Kim, Mitsumasa Kishimoto, Naoki Ogusu, Haeyoun Jeong, Shigeto Kobayashi
Summary: Brodalumab demonstrated significant improvement in patients with active axSpA at week 16. The safety profile of brodalumab was consistent with previous reports from global/Japanese psoriasis studies.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Guan Zheng, Xiaoshuai Peng, Yunhui Zhang, Peng Wang, Zhongyu Xie, Jinteng Li, Wenjie Liu, Guiwen Ye, Yucong Lin, Guojian Li, Huatao Liu, Chenying Zeng, Lihua Li, Yanfeng Wu, Huiyong Shen
Summary: In this study, manganese ferrite nanoparticles modified by the aptamer CH6 (CH6-MF NPs) were developed for the efficient treatment of ankylosing spondylitis (AS). The CH6-MF-Si NPs effectively suppressed abnormal osteogenic differentiation under inflammatory conditions in vitro and attenuated local inflammation and rescued heterotopic ossification in the entheses in a mouse model. These findings suggest that CH6-MF NPs may serve as an effective inflammation reliever and osteoblast-specific delivery system, and CH6-MF-Si NPs have potential for the dual treatment of chronic inflammation and heterotopic ossification in AS.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Rheumatology
Samantha S. R. Crossfield, Helena Marzo-Ortega, Sarah R. Kingsbury, Mar Pujades-Rodriguez, Philip G. Conaghan
Summary: This study found that the incidence of ankylosing spondylitis decreased between 1998 and 2007, then increased from 2007 to 2017. The rising prevalence may indicate improved patient survival. However, there is a persisting delay in rheumatology referral and diagnosis, particularly in women.
Article
Rheumatology
Laura Passalent, Alaina Cyr, Igor Jurisica, Sunita Mathur, Robert D. Inman, Nigil Haroon
Summary: This study aims to understand the importance of physical activity in managing axial spondyloarthritis (SpA), identify factors affecting adherence to physical activity, and explore the role of e-health technology in facilitating physical activity for patients with axial SpA. Participants recognized the role of physical activity in SpA management, with motivators including mindset, social support, and access to facilities, and barriers including fear of disease progression and life demands. E-health technology components such as feedback, reminders, and virtual support networks were found to be effective in promoting engagement in physical activity for patients with axial SpA.
ARTHRITIS CARE & RESEARCH
(2022)
Review
Orthopedics
E. C. Bell, J. A. Wallis, A. J. Goff, K. M. Crossley, P. O'Halloran, C. J. Barton
Summary: This study investigated the effects of land-based exercise therapy on physical activity in people with knee osteoarthritis (KOA). The findings suggest that walking and mixed-exercise programs can improve physical activity in the short-term for KOA patients, while resistance-training alone does not have a significant impact. Combining resistance-training with education may increase physical activity in the medium-term, highlighting the importance of developing more effective long-term interventions for KOA patients.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Review
Physiology
Wei Wang, Yonggang Niu, Qingxiu Jia
Summary: Osteoarthritis is the most prevalent joint disease and a leading cause of disability in older adults. The disease is caused by the breakdown of joint tissues from mechanical loading and inflammation. While pharmacological treatments focus on symptom relief, regular practice of resistance exercise shows promise in preventing and controlling musculoskeletal chronic diseases, including osteoarthritis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Dermatology
Alina I. Marusina, Antonio Ji-Xu, Stephanie T. Le, Atrin Toussi, Lam C. Tsoi, Qinyuan Li, Guillaume Luxardi, Jordan Nava, Lauren Downing, Annie R. Leal, Nikolay Y. Kuzminykh, Olga Kruglinskaya, Marie-Charlotte Bruggen, Iannis E. Adamopoulos, Alexander A. Merleev, Johann E. Gudjonsson, Emanual Maverakis
Summary: ERAP1, ERAP2, and LNPEP, which are aminopeptidases, play a role in autoimmune diseases. The expression of ERAP2 is increased while ERAP1 is decreased in psoriasis patients with autoimmune-linked variants of ERAP. Different layers of skin cells show different expression patterns of aminopeptidases, and in psoriasis, basal keratinocytes also express CCL2 and IL-15. In addition, ERAP2-high skin fibroblasts also express more CXCL14.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Rheumatology
Ana De Vicente Delmas, Lara Sanchez-Bilbao, Vanesa Calvo-Rio, David Martinez-Lopez, Alba Herrero-Morant, Eva Galindez-Agirregoikoa, Inigo Gonzalez-Mazon, Nuria Barroso-Garcia, Natalia Palmou-Fontana, Miguel A. Gonzalez-Gay, Jose L. Hernandez, Ricardo Blanco
Summary: This study aimed to assess the frequency and clinical features of uveitis in psoriatic arthritis (PsA) patients, as well as its association with disease activity, functional disability, and biological treatment. The prevalence of uveitis in PsA patients was about 5%, and it was associated with a worse quality of life and greater functional disability. The incidence rate of uveitis varied depending on the type of biological treatment used.