Article
Medicine, General & Internal
Romina Abelleira, Carlos Zamarron, Alberto Ruano, Tamara Lourido, Nuria Rodriguez-Nunez, Francisco J. Gonzalez-Barcala, Maria E. Toubes, Jose M. Alvarez-Dobano, Jorge Ricoy, Luis Valdes
Summary: The study suggests a relationship between diabetes mellitus and sleep apnoea-hypopnoea syndrome, indicating a higher risk of peripheral neuropathy in patients with both diseases.
Article
Pharmacology & Pharmacy
Manjiri P. P. Jalgaonkar, Urvi M. M. Parmar, Yogesh A. A. Kulkarni, Manisha J. J. Oza
Summary: The prevalence of diabetes is increasing, leading to microvascular and macrovascular complications. The interaction between SIRT1 and FOXOs plays an important role in controlling and alleviating diabetic complications, suggesting them as potential therapeutic targets.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Joshua Kuan Tan, Gek Hsiang Lim, Nur Nasyitah Mohamed Salim, Sing Yi Chia, Julian Thumboo, Yong Mong Bee
Summary: The study investigates the association between mean HbA1c, HbA1c variability, and all-cause mortality and diabetes-related macrovascular complications in patients with diabetes. The results show that both low (<6%) and high (>=8%) levels of HbA1c are associated with increased risk of all-cause mortality and diabetes-related macrovascular complications. Patients with stable HbA1c levels of 6-8% have the lowest risk.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Archana Sharma, Ingrid Nermoen, Elisabeth Qvigstad, Anh T. Tran, Christine Sommer, Naveed Sattar, Jason M. R. Gill, Hanne L. Gulseth, Stina T. Sollid, Kare Birkeland
Summary: This study revealed significant ethnic differences in actionable ADA-HbA(1c) levels between South Asian and Nordic women with previous GDM, with important risk factors including South Asian ethnicity, GDM history, use of glucose-lowering drugs during pregnancy, older age, and higher fasting glucose levels during pregnancy.
Review
Endocrinology & Metabolism
Eric Pasqualotto, Janine Midori Figueiredo Watanabe, Douglas Mesadri Gewehr, Raphaela da Silva Maintinguer, Simone van de Sande-Lee, Gustavo Neves de Araujo, Fidel Silveira Leal, Carlos Eduardo Andrade Pinheiro
Summary: This study found that bexagliflozin can effectively reduce HbA1c levels, blood pressure, and body weight in patients with T2DM, with similar side effects compared to placebo.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biology
Cristina Garcia-Serrano, Jesus Pujol Salud, Lidia Aran-Sole, Joaquim Sol, Sonia Ortiz-Congost, Eva Artigues-Barbera, Marta Ortega-Bravo
Summary: Improving sleep habits may improve glucose metabolism in individuals with type 2 diabetes. This study aimed to determine the effectiveness of an educational intervention on sleep hygiene in patients with prediabetes and type 2 diabetes. The results showed significant improvements in sleep quality and diabetes control in the intervention group compared to the control group.
Review
Medicine, General & Internal
Pasquale Tondo, Francesco Fanfulla, Roberto Sabato, Giulia Scioscia, Maria Pia Foschino Barbaro, Donato Lacedonia
Summary: Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) is a common and complex respiratory disorder with a significant impact on health and quality of life. Despite affecting approximately one billion individuals worldwide, OSAHS remains underestimated due to misinformation among patients and physicians. Therefore, a multidisciplinary approach is necessary for the design and implementation of diagnostic and therapeutic programs to provide personalized treatment for each patient.
Review
Anesthesiology
Daniel J. Drayton, Rebecca J. Birch, Carlota D'Souza-Ferrer, Michael Ayres, Simon J. Howell, Ramzi A. Ajjan
Summary: This study conducted a scoping review to examine the association between diabetes mellitus (DM) and adverse perioperative outcomes. The results showed that the definition of DM in the published literature is inconsistent, limiting the potential for pooled analysis. The study findings suggest that DM is associated with adverse outcomes such as mortality, complications, and infections.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Neurosciences
Pasquale Tondo, Francesco Fanfulla, Giulia Scioscia, Roberto Sabato, Michela Salvemini, Cosimo C. De Pace, Maria Pia Foschino Barbaro, Donato Lacedonia
Summary: This study found that in young, non-obese individuals, severe obstructive sleep apnoea (OSA) is associated with an increased risk of developing hypertension and nocturnal hypoxemia.
Article
Biochemistry & Molecular Biology
Jiahang Li, Lei Shi, Guohong Zhao, Fei Sun, Zhenxing Nie, Zhongli Ge, Bin Gao, Yan Yang
Summary: This study aimed to investigate the correlation between lipid profiles and microvascular complications in type 2 diabetes. The results showed that high triglyceride levels are associated with increased risk of diabetic nephropathy, retinopathy, and peripheral neuropathy. It is recommended for patients with older age, longer duration of diabetes, and higher HbA1c levels to more strictly control their lipid levels.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Pei Xue, Xiao Tan, Christian Benedict
Summary: This study investigated the association between socioeconomic deprivation and sleep health indicators in patients with type 2 diabetes mellitus, as well as whether socioeconomic deprivation is associated with higher HbA1c levels in these patients. The results showed that socioeconomic deprivation is associated with poor sleep health and inadequate blood sugar control.
DIABETES OBESITY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Urvi M. Parmar, Manjiri P. Jalgaonkar, Aayush J. Kansara, Manisha J. Oza
Summary: Diabetes and its complications are on the rise globally, and this review focuses on the role of FOXO transcription factors in regulating diabetic complications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
E. T. Parmaksiz, E. Parmaksiz
Summary: This study identified an association between severe obstructive sleep apnoea and increased HbA(1c) levels, suggesting it should be considered as a component of the metabolic syndrome.
DIABETES STOFFWECHSEL UND HERZ
(2021)
Review
Nutrition & Dietetics
Rosario Suarez, Sebastian P. Chapela, Ludwig Alvarez-Cordova, Estefania Bautista-Valarezo, Yoredy Sarmiento-Andrade, Ludovica Verde, Evelyn Frias-Toral, Gerardo Sarno
Summary: A long-term complication of obesity is the development of type 2 diabetes (T2D), which involves epigenetic modifications. Epigenetics refers to post-transcriptional modifications of DNA or associated factors that influence gene expression. The epigenetic modifications involved in T2D include DNA methylation, acetylation, ubiquitylation, SUMOylation, and phosphorylation. These modifications have been observed in various tissues and are also found in chronic complications of T2D. A new drug, apabetalone, which targets epigenetic readers, is being studied as a potential treatment for T2D and its cardiovascular complications.
Article
Spectroscopy
Priyanka A. Jadhav, Arti Hole, M. Sivaprasad, K. Viswanath, Manisha Sahay, Rakesh Sahay, G. Bhanuprakash Reddy, C. Murali Krishna
Summary: Diabetes is a major global public health challenge, and its complications pose high risks to patients. This study used Raman Spectroscopy to analyze plasma samples from diabetes patients and found a decrease in protein content. The classification accuracy of Raman spectra was lower in the diabetes and complications groups, but a small number of complications samples were misclassified as control group. These findings suggest that Raman Spectroscopy may be useful for early detection or diagnosis of diabetic complications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Urology & Nephrology
Jingya Wang, Krishnarajah Niratharakumar, Krishna Gokhale, Abd A. Tahrani, Tom Taverner, G. Neil Thomas, Indranil Dasgupta
Summary: The study found that metabolically healthy obesity and overweight are associated with an increased risk of incident chronic kidney disease in a British primary care population. This association was stronger in those under 65 years old and there was a greater risk of CKD with a greater number of metabolic abnormalities in all BMI categories.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Clinical Neurology
Andreas Yiangou, James L. Mitchell, Matthew Nicholls, Yu Jeat Chong, Vivek Vijay, Benjamin R. Wakerley, Gareth G. Lavery, Abd A. Tahrani, Susan P. Mollan, Alexandra J. Sinclair
Summary: This study found that obesity is a risk factor for IIH and OSA, with OSA being common in IIH patients. Treatment with bariatric surgery can improve OSA in IIH patients, and improvement in AHI is closely related to improvement in papilloedema.
JOURNAL OF NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Theresa J. Hydes, Daniel J. Cuthbertson, Suzanne Graef, Sarah Berhane, Mabel Teng, Anna Skowronska, Pushpa Singh, Sofi Dhanaraj, Abd Tahrani, Philip J. Johnson
Summary: The study found a significant association between diabetes and hepatocellular carcinoma (HCC) in the United Kingdom, and metformin treatment was associated with improved overall survival after HCC diagnosis.
CLINICAL THERAPEUTICS
(2022)
Article
Nutrition & Dietetics
Raymond Kodsi, Ritesh Chimoriya, David Medveczky, Kathy Grudzinskas, Evan Atlantis, Abd A. Tahrani, Nic Kormas, Milan K. Piya
Summary: This study aimed to evaluate the effects of an intensive non-surgical weight management program on weight loss and metabolic outcomes in patients with varying degrees of weight-related complications. The results showed that after 12 months of treatment, there was significant weight loss and improvement in metabolic parameters in both groups, regardless of the severity of complications. This suggests that intensive non-surgical weight management programs can be effective in achieving clinically meaningful weight loss in patients with severe obesity.
Article
Clinical Neurology
Mark Thaller, Benjamin R. Wakerley, Sally Abbott, Abd A. Tahrani, Susan P. Mollan, Alexandra J. Sinclair
Summary: Idiopathic intracranial hypertension (IIH) is more common in obese women of reproductive age. The management of IIH during pregnancy should be carefully considered, including pre-pregnancy contraception and weight control. Potentially teratogenic medications should be avoided during pregnancy, and the use of acetazolamide should be discussed with the patient and obstetrician. Controlling weight gain is important to prevent exacerbation of IIH and maternal and fetal complications. Most women with IIH can have a normal vaginal delivery if the papilloedema is stable or the IIH is in remission.
PRACTICAL NEUROLOGY
(2022)
Review
Endocrinology & Metabolism
Lisa M. Shepherd, Kelly Ann Schmidtke, Jonathan M. Hazlehurst, Eka Melson, Janine Dretzke, Noel Hawks, Wiebeke Arlt, Abd A. Tahrani, Amelia Swift, Debbie M. Carrick-Sen
Summary: The study identified and evaluated interventions aiming to prevent adrenal crisis in primary adrenal insufficiency, focusing on patient education and behavior change techniques. However, most studies did not measure the effectiveness of these interventions, indicating a need for further research in this area.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Susan P. Mollan, James L. Mitchell, Andreas Yiangou, Ryan S. Ottridge, Zerin Alimajstorovic, David M. Cartwright, Simon J. Hickman, Keira A. Markey, Rishi Singhal, Abd A. Tahrani, Emma Frew, Kristian Brock, Alexandra Jean Sinclair
Summary: This study aimed to evaluate the amount of weight loss required to reduce intracranial pressure and explore the effect of different bariatric surgical approaches. The results showed that weight loss was significantly associated with a reduction in intracranial pressure, and Roux-en-Y gastric bypass achieved greater, more rapid, and sustained reduction in intracranial pressure compared to other methods.
Article
Surgery
Pushpa Singh, Nicola J. Adderley, Anuradhaa Subramanian, Krishna Gokhale, Jonathan Hazlehurst, Rishi Singhal, Srikanth Bellary, Abd A. Tahrani, Krishnarajah Nirantharakumar
Summary: This study retrospectively examined the impact of bariatric surgery on glycemic control and medication use in patients with type 2 diabetes. The results showed that bariatric surgery can significantly improve glycemic control, achieve normal HbA1C levels, and reduce the need for glucose-lowering therapy.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Surgery
Rishi Singhal, Tom Wiggins, Sjaak Pouwels, Yashasvi Rajeev, Brijesh Madhok, Wasim Hanif, Abd A. Tahrani, Yitka Graham, Christian Ludwig, Kamal Mahawar
Summary: This study provides global real-world data on the recovery of BMS services following the COVID-19 pandemic, including patterns of service delivery, recovery practices, and protective measures taken. The study found that smaller hospitals were able to restart BMS programs more rapidly, while government-funded institutions took longer to recover their services.
Article
Endocrinology & Metabolism
Ben Imholz, Jack Heijster, Abd Tahrani, Adriaan Kooy
Summary: This study assessed the efficacy of frequency rhythmic electromagnetic neural stimulation (FREMS) in patients with painful diabetic peripheral neuropathy (PDPN). The results showed that FREMS treatment was associated with a significant reduction in pain severity, suggesting its potential therapeutic role in non-responders to pharmacotherapy.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGET & THERAPY
(2023)
Article
Endocrinology & Metabolism
Jamy Ard, Cecilie Olivia Andersen, Kasper Sommer Matthiessen, Camilla S. Morgen, Naveen Rathor, Deepak Yerragolam, Abd A. Tahrani
Summary: This study compared eligible individuals who did and did not undergo bariatric surgery, and found that those who did not undergo surgery experienced worsening health and increasing healthcare costs over 3 years, indicating a significant unmet need for clinically indicated obesity treatment.
Article
Clinical Neurology
Zerin Alimajstorovic, James L. Mitchell, Andreas Yiangou, Thomas Hancox, Andrew D. Southam, Olivia Grech, Ryan Ottridge, Catherine L. Winder, Abd A. Tahrani, Tricia M. Tan, Susan P. Mollan, Warwick B. Dunn, Alexandra J. Sinclair
Summary: Weight loss in patients with idiopathic intracranial hypertension leads to a reduction in intracranial pressure by altering gut neuropeptides and lipid metabolites, with increased glucagon-like peptide-1 secretion being associated with lower intracranial pressure.
BRAIN COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Rishi Singhal, Islam Omar, Brijesh Madhok, Christian Ludwig, Abd A. Tahrani, Kamal Mahawar
Summary: This study assessed the safety of expedited bariatric surgery for patients with a BMI > 60 kg/m2 during the COVID-19 pandemic. The results showed a higher 30-day mortality rate in patients with BMI > 60 kg/m2, but no significant difference in complication rates compared to other BMI groups, likely due to differences in procedure selection.
OBESITY RESEARCH & CLINICAL PRACTICE
(2022)
Article
Sport Sciences
Laurence J. Dobbie, Theresa J. Hydes, Uazman Alam, Abd Tahrani, Daniel J. Cuthbertson
Summary: The COVID-19 pandemic has resulted in decreased physical activity, particularly in terms of greenspace and residence mobility as well as walking levels. The study found that more stringent lockdown measures were associated with greater reductions in greenspace mobility and walking directions. Additionally, vulnerable populations such as the elderly and BAME individuals were more likely to become physically inactive. This highlights the importance of urban planning in prioritizing greenspace development to improve walkability and physical activity levels.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2022)
Article
Endocrinology & Metabolism
Krishna Gokhale, Samiul A. Mostafa, Jingya Wang, Abd A. Tahrani, Christopher Andrew Sainsbury, Konstantinos A. Toulis, G. Neil Thomas, Zaki Hassan-Smith, Elizabeth Sapey, Suzy Gallier, Nicola Jaime Adderley, Parth Narendran, Srikanth Bellary, Tom Taverner, Sandip Ghosh, Krishnarajah Nirantharakumar, Wasim Hanif
Summary: This study assessed the clinical profiles and mortality rates in COVID-19 patients with and without diabetes complications, showing that those with diabetes and complications presented with a more severe clinical and biochemical profile, but did not have significantly increased mortality compared to other groups.
ENDOCRINOLOGY DIABETES & METABOLISM
(2022)
