Article
Health Care Sciences & Services
Kyma Schnoor, Anke Versluis, Robbert Bakema, Sanne van Luenen, Marcel J. Kooij, J. Maurik van den Heuvel, Martina Teichert, Persijn J. Honkoop, Job F. M. van Boven, Niels H. Chavannes, Jiska J. Aardoom
Summary: The SARA eHealth intervention shows potential in reducing exacerbation rates and improving medication adherence among patients with asthma and COPD.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Allergy
Fahad H. Alahmadi, Brian Keevil, Lynn Elsey, Kate George, Robert Niven, Stephen J. Fowler
Summary: LC-MS/MS can reliably detect commonly used ICSs in the blood at least 8 hours after dosing, providing a measure of adherence in severe asthma patients. Lower blood levels were associated with higher exacerbation rates and poorer lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Critical Care Medicine
Fahad H. Alahmadi, Andrew J. Simpson, Cristina Gomez, Magnus Ericsson, John-Olof Thorngren, Craig E. Wheelock, Dominic E. Shaw, Louise J. Fleming, Graham Roberts, John Riley, Stewart Bates, Ana R. Sousa, Richard Knowles, Aruna T. Bansal, Julie Corfield, Ioannis Pandis, Kai Sun, Per S. Bakke, Massimo Caruso, Pascal Chanez, Barbro Dahlen, Ildiko Horvath, Norbert Krug, Paolo Montuschi, Florian Singer, Scott Wagers, Ian M. Adcock, Ratko Djukanovic, Kian Fan Chung, Peter J. Sterk, Sven-Erik Dahlen, Stephen J. Fowler
Summary: Low adherence is a common issue in severe asthma patients, whether measured directly or self-reported. There is poor agreement between the two methods, suggesting a disassociation between self-assessment of medication adherence and actual oral corticosteroid use, indicating that each approach may provide complementary information in clinical practice.
Article
Biochemistry & Molecular Biology
Mingmin Zhao, Kreshnik Hoti, Hao Wang, Aniruddh Raghu, Dina Katabi
Summary: The study utilizes artificial intelligence and wireless sensors to monitor patient medication use, particularly common errors with inhalers or insulin pens. Results show that the AI framework can automatically detect whether patients are using inhalers or insulin pens correctly, demonstrating potential for improving medication safety.
Article
Critical Care Medicine
Jacob T. Maddux, Jonathan W. Inselman, Molly M. Jeffery, Regina W. Lam, Nilay D. Shah, Matthew A. Rank
Summary: This study reveals that adherence to asthma biologics is higher than to ICS and is associated with different factors. Adherence to ICS before starting asthma biologics and during the first 6 months of biologic use is significantly related to biologic adherence, but not significantly associated with a reduction in asthma exacerbations.
Article
Pediatrics
Shahid I. Sheikh, Nancy A. Ryan-Wenger, Judy Pitts, Rodney Britt, Grace Paul, Lisa Ulrich
Summary: This study compared asthma control over one year among AA and CA children managed per NAEPP guidelines, finding similar improvement in asthma control between the two groups over time, with a significant decrease in ED visits for AA children.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Allergy
Peter J. Cvietusa, Glenn K. Goodrich, Jo Ann Shoup, Diane K. King, Bruce G. Bender
Summary: This study aimed to measure asthma medication adherence in the 12 months after an asthma exacerbation and explore the influence of care type and socioeconomic status on adherence. The results showed a significant improvement in medication adherence after an asthma exacerbation, especially in patients with multiple exacerbations. Seeing a specialist after the exacerbation, rather than before, resulted in the greatest improvement in adherence. Additionally, patients with lower socioeconomic status had lower adherence before the exacerbation but showed a similar improvement compared to those with higher socioeconomic status.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Amir Hossein Alizadeh Bahmani, Elise M. A. Slob, Lizan D. Bloemsma, Susanne Brandstetter, Paula Corcuera-Elosegui, Mario Gorenjak, Susanne Harner, Simone Hashimoto, Anna M. Hedman, Michael Kabesch, Gerard H. Koppelman, Javier Korta-Murua, Aletta D. Kraneveld, Anne H. Neerincx, Marielle W. Pijnenburg, Maria Pino-Yanes, Uros Potocnik, Olaia Sardon-Prado, Susanne J. H. Vijverberg, Christine Wolff, Mahmoud Abdel-Aziz, Anke H. Maitland-van der Zee
Summary: This multicountry, observational, case-control study aimed to compare treatment regimens, inhaler techniques, medication adherence, and other characteristics of controlled and uncontrolled pediatric asthma. The study found that children in higher treatment steps had a higher risk of uncontrolled asthma, and the risk was also associated with a larger change in lung function post and pre-salbutamol. However, adherence and inhaler techniques were not related to the risk of uncontrolled asthma. Other factors, such as environmental factors and biological profiles, may influence the risk of uncontrolled asthma in this population.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jeffrey Chidester, Daniel Bennett, Chris Mathew, Tiffany Denkins, Rebecca Vigen, Tayo Addo, Sandeep Das
Summary: A telephone-based reminder system was developed to improve DAPT adherence post-PCI, leading to directed interventions in nearly 1 in 10 patients contacted. However, the system did not significantly improve PDC levels compared to a contemporary sample, highlighting the ongoing difficulty in detecting barriers to adherence.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Terri L. Byczkowski, Anna-Liisa B. Vockell, David J. Krier, Maria T. Britto
Summary: This study aimed to develop a questionnaire to segment adolescents with asthma into different archetypes based on their motivations for individualized self-management interventions. Six archetypes were identified and described, and a 17-item questionnaire was developed to identify these archetypes. The study has important implications for healthcare professionals to customize adherence interventions for different segments of adolescents.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Medicine, General & Internal
Stephanie Tchen, Truong Vu, Megan Fleischman, Jory Ward, Caitlyn Trapp, Kurt Hu
Summary: This study aimed to assess provider adherence to the GINA guidelines regarding reliever therapy. The results showed a low rate of prescription for recommended reliever therapy among patients with acute asthma exacerbation, although there was an improvement following hospitalization.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Michael Asamoah-Boaheng, Jamie Farrell, Kwadwo Osei Bonsu, Alwell Oyet, William K. Midodzi
Summary: The adherence level to asthma medication is associated with the risk of COPD, with optimal and intermediate adherence levels being linked to a reduced risk. Additionally, severe asthma patients with low medication adherence have an increased risk of COPD.
CLINICAL EPIDEMIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Holly Tibble, Mary Flook, Aziz Sheikh, Athanasios Tsanas, Rob Horne, Bernard Vrijens, Sabina De Geest, Helen R. Stagg
Summary: Medication non-adherence can lead to increased morbidity, mortality, and side effects, while reducing effectiveness. Methodological issues exist in measuring and reporting adherence for asthma and TB, with variations between and within diseases. The communicable nature of TB has made dose-by-dose monitoring a recommended treatment standard.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
P. Michael Ho, Colin I. O'Donnell, Marina McCreight, Anthony A. Bavry, Hayden B. Bosworth, Saket Girotra, P. Michael Grossman, Christian Helfrich, Faisal Latif, David Lu, Michael Matheny, Kreton Mavromatis, Jose Ortiz, Amitabh Parashar, Devona M. Ratliff, Gary K. Grunwald, Michael Gillette, Hani Jneid
Summary: This study assessed the effectiveness of a multifaceted intervention targeting P2Y12 inhibitor adherence and found that while the intervention improved adherence, it also led to an increase in repeat PCI procedures.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Cardiac & Cardiovascular Systems
Constanca Monteiro, Tiago Maricoto, Filipe Prazeres, Pedro Augusto Simoes, Jose Augusto Simoes
Summary: This study reviewed global literature to identify the main determinants of adherence to inhaled therapy for asthma and COPD. The study found that older age, good disease knowledge/literacy, obesity, good cognitive performance, higher income, being employed, and using multiple drugs/inhalers were significant determinants of adherence. However, the overall strength of the evidence was only low to moderate.
RESPIRATORY MEDICINE
(2022)
Article
Respiratory System
Kaharu Sumino, Emily R. Locke, Sheryl Magzamen, Ina Gylys-Colwell, Olivier Humblet, Huong Q. Nguyen, Rachel M. Thomas, Vincent S. Fan
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2018)
Article
Allergy
Andrea M. Coverstone, Brad Wilson, Dana Burgdorf, Kenneth B. Schechtman, Gregory A. Storch, Michael J. Holtzman, Mario Castro, Leonard B. Bacharier, Kaharu Sumino
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Tiffany Dy, Ericka M. Lewis, Vithya Murugan, Sarah Gehlert, Juanita Taylor, Jane Garbutt, Leonard B. Bacharier, Mario Castro, Kaharu Sumino
RESPIRATORY MEDICINE
(2018)
Article
Allergy
Juan Carlos Cardet, Xiaofeng Jiang, Quan Lu, Norma Gerard, Kristen McIntire, Homer A. Boushey, Mario Castro, Vernon M. Chinchilli, Christopher D. Codispoti, Anne-Marie Dyer, Fernando Holguin, Monica Kraft, Stephen Lazarus, Robert F. Lemanske, Njira Lugogo, Dave Mauger, Wendy C. Moore, James Moy, Victor E. Ortega, Stephen P. Peters, Lewis J. Smith, Julian Solway, Christine A. Sorkness, Kaharu Sumino, Michael E. Wechsler, Sally Wenzel, Elliot Israel
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Respiratory System
David A. Kaminsky, David G. Chapman, Janet T. Holbrook, Robert J. Henderson, Elizabeth A. Sugar, John Mastronarde, William G. Teague, Michael Busk, Kaharu Sumino, Anne E. Dixon, Robert A. Wise, Charles G. Irvin
Article
Allergy
Andrea M. Coverstone, Leyao Wang, Kaharu Sumino
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
(2019)
Letter
Allergy
Juan Carlos Cardet, Xiaofeng Jiang, Quan Lu, Norma Gerard, Kristen McIntire, Homer A. Boushey, Mario Castro, Vernon M. Chinchilli, Christopher D. Codispoti, Anne-Marie Dyer, Fernando Holguin, Monica Kraft, Stephen Lazarus, Robert F. Lemanske, Njira Lugogo, Dave Mauger, Wendy C. Moore, James Moy, Victor E. Ortega, Stephen P. Peters, Lewis J. Smith, Julian Solway, Christine A. Sorkness, Kaharu Sumino, Michael E. Wechsler, Sally Wenzel, Elliot Israel
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Allergy
Kaharu Sumino, Leonard B. Bacharier, Juanita Taylor, Kelley Chadwick-Mansker, Vanessa Curtis, Alison Nash, Shawni Jackson-Triggs, Joseph Moen, Kenneth B. Schechtman, Jane Garbutt, Mario Castro
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Letter
Allergy
Kaharu Sumino
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Article
Allergy
Sonali Bose, Christian Bime, Robert J. Henderson, Kathryn Blake, Mario Castro, Emily DiMango, Nicola A. Hanania, Janet T. Holbrook, Charles G. Irvin, Monica Kraft, Stephen P. Peters, Joan Reibman, Elizabeth A. Sugar, Kaharu Sumino, Robert A. Wise, Linda Rogers
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Article
Allergy
Cary D. Austin, Melissa Gonzalez Edick, Ronald E. Ferrando, Margaret Solon, Miriam Baca, Kathryn Mesh, Peter Bradding, Gail M. Gauvreau, Kaharu Sumino, J. Mark FitzGerald, Elliot Israel, Lief Bjermer, Arnaud Bourdin, Joseph R. Arron, David F. Choy, Julie K. Olsson, Francis Abreu, Monet Howard, Kit Wong, Fang Cai, Kun Peng, Wendy S. Putnam, Cecile T. J. Holweg, John G. Matthews, Monica Kraft, Prescott G. Woodruff
CLINICAL AND EXPERIMENTAL ALLERGY
(2020)
Article
Critical Care Medicine
Tim W. Harrison, Pascal Chanez, Francesco Menzella, Giorgio Walter Canonica, Renaud Louis, Borja G. Cosio, Njira L. Lugogo, Arjun Mohan, Annie Burden, Lawrence McDermott, Esther Garcia Gil, James G. Zangrilli
Summary: The study aimed to evaluate the efficacy of benralizumab in severe eosinophilic asthma patients, including onset of effect, impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms. Results showed that benralizumab significantly reduced exacerbation risk and improved HRQOL, lung function, and nasal symptoms early in the treatment period compared to placebo.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Allergy
Vickram Tejwani, Hsing-Yuan Chang, Annie P. Tran, Jennifer Al Naber, Florian S. Gutzwiller, Tonya A. Winders, Sandhya Khurana, Kaharu Sumino, Giselle Mosnaim, Rachael M. Moloney
Summary: The study aimed to develop a core set of outcomes for clinical drug trials in patients with moderate-to-severe asthma, including outcomes such as asthma exacerbation, change in asthma control, quality of life, hospital stay, and emergency department visit. These 5 core outcomes will allow for meaningful comparisons of asthma therapies across clinical trials.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Rekha Chaudhuri, Adalberto Rubin, Kaharu Sumino, Jose Roberto Lapa e Silva, Robert Niven, Salman Siddiqui, Karin Klooster, Charlene McEvoy, Pallav L. Shah, Michael Simoff, Sumita Khatri, Richard Barbers, G. Mark Grubb, Edmund A. McMullen, Jennifer L. Olson, Michel Laviolette
Summary: The BT10+ study followed participants from previous clinical trials for over 10 years and found that bronchial thermoplasty treatment remained effective and safe for asthma patients, providing a long-lasting therapeutic option.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Arjun Mohan, Amy Ludwig, Caryn Brehm, Njira L. Lugogo, Kaharu Sumino, Nicola A. Hanania
Summary: Asthma is a common chronic airways disease, and although it has a significant impact on patients, there is still a lack of consensus on the definition and clinical progression of mild asthma. Recent changes in the treatment approach for mild asthma have led to controversies and unmet needs.
