Cyclin-Dependent kinase 5 targeting prevents β-Amyloid aggregation involving glycogen synthase kinase 3β and phosphatases

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Cytoplasmic Retention of Protein Phosphatase 2A Inhibitor 2 (I2PP2A) Induces Alzheimer-like Abnormal Hyperphosphorylation of Tau

(2014) Mohammad Arif et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach

(2014) John F. Castro-Alvarez et al.   Frontiers in Aging Neuroscience

Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer’s mice

(2014) John F. Castro-Alvarez et al.   Frontiers in Aging Neuroscience

Formation of Dynamic Soluble Surfactant-induced Amyloid β Peptide Aggregation Intermediates

(2013) Axel Abelein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5

(2013) Hailong Hou et al.   JOURNAL OF CELL BIOLOGY

Neuroprotective effects of donepezil against Aβ42-induced neuronal toxicity are mediated through not only enhancing PP2A activity but also regulating GSK-3β and nAChRs activity

(2013) Min-Young Noh et al.   JOURNAL OF NEUROCHEMISTRY

Silencing PP2A Inhibitor by Lenti-shRNA Interference Ameliorates Neuropathologies and Memory Deficits in tg2576 Mice

(2013) Gong-Ping Liu et al.   MOLECULAR THERAPY

Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease

(2013) Guang Yu et al.   NEUROBIOLOGY OF AGING

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease–Like Pathology and Cognitive Decline in Aged 3xTgAD Mice

(2012) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance

(2012) Celia López-Menéndez et al.   HUMAN MOLECULAR GENETICS

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Synapses and Alzheimer's Disease

(2012) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Mice lacking phosphatase PP2A subunit PR61/B'  (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3 

(2011) J. V. Louis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease

(2011) L Crews et al.   Cell Death & Disease

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial: Figure 1

(2010) Khalid Iqbal et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cdk5, the multifunctional surveyor

(2010) Vassiliki Lalioti et al.   CELL CYCLE

Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

(2010) Bin Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice

(2010) D. Piedrahita et al.   JOURNAL OF NEUROSCIENCE

Regulation of GSK3 isoforms by phosphatases PP1 and PP2A

(2010) Félix Hernández et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

(2009) Ryan L Boudreau et al.   MOLECULAR THERAPY

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3  Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing

(2008) Y. Wen et al.   JOURNAL OF NEUROSCIENCE

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

(2008) Yi Wen et al.   NEURON

PP1 inhibition by Aβ peptide as a potential pathological mechanism in Alzheimer's disease

(2008) Ana Paula B. Vintém et al.   NEUROTOXICOLOGY AND TERATOLOGY

Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs

(2008) R. L. Boudreau et al.   RNA