Journal
CURRENT OPINION IN PLANT BIOLOGY
Volume 19, Issue -, Pages 99-104Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2014.05.007
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Funding
- National Science Foundation [IOS 1238189]
- National Institutes of Health [R01 GM098861]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1238189] Funding Source: National Science Foundation
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Recent advances in DNA targeting allow unprecedented control over gene function and expression. Targeting based on TAL effectors is arguably the most promising for systems biology and metabolic engineering. Multiple, orthogonal TAL-effector reagents of different types can be used in the same cell. Furthermore, variation in base preferences of the individual structural repeats that make up the TAL effector DNA recognition domain makes targeting stringency tunable. Realized applications range from genome editing to epigenome modification to targeted gene regulation to chromatin labeling and capture. The principles that govern TAL effector DNA recognition make TAL effectors well suited for applications relevant to plant physiology and metabolism. TAL effector targeting has merits that are distinct from those of the RNA-based DNA targeting CRISPR/Cas9 system.
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