Journal
CURRENT OPINION IN PLANT BIOLOGY
Volume 14, Issue 5, Pages 480-488Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2011.06.003
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Funding
- Max Planck Society
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Structural biology efforts in recent years have generated numerous co-crystal structures of bioactive small molecules interacting with their plant targets. These studies include the targets of various phytohormones, pathogen-derived effectors, herbicides and other bioactive compounds. Here we discuss that this collection of structures contains excellent examples of nine collective observations: molecular glues, allostery, inhibitors, molecular mimicry, promiscuous binding sites, unexpected electron densities, natural selection at atomic resolution, and applications in structure-guided mutagenesis and small molecule design.
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