Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 15, Issue -, Pages 83-90Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2013.12.005
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- Deutsche Forschungsgemeinschaft (DFG)
- LMU Mentoring program
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Hyperpolarization-activated cyclic nucleotide gated (HCN) channels pass a cationic current (l(h)/l(f)) that crucially contributes to the slow diastolic depolarization (SDD) of sinoatrial pacemaker cells and, hence, is a key determinant of cardiac automaticity and the generation of the heart beat. There is growing evidence, that HON channel functions in the sinoatrial node (SAN) are not restricted to impulse formation but are also required for impulse propagation. In addition, HON channels are involved in coordination and maintenance of sinoatrial network activity and, hence, are crucial for stabilizing cardiac rhythmicity. In the present review we will outline these new concepts.
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