Review
Biology
Jakub Tomek, Manuela Zaccolo
Summary: In the past 30 years, the understanding of cyclic adenosine 3',5'-monophosphate (cAMP) signaling has changed from a linear pathway to a complex network, where spatial regulation of cAMP plays a critical role. This new model provides novel insights into cardiac myocyte physiology and provides a framework for identifying disease mechanisms, particularly in the regulation of cardiac rhythm.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Zhengyin Gao, Weng Lei, Leo Tsz On Lee
Summary: This review focuses on the role of neuropeptide/GPCR system modulation of cAMP/EPACs pathways in cancers, discussing the potential mechanisms and implications in cancer cell proliferation, migration, and metastasis.
Review
Physiology
Ester Paolocci, Manuela Zaccolo
Summary: cAMP is a universal second messenger that controls cellular functions via precise regulation. Dysfunction of ciliary signaling leads to ciliopathies like ADPKD. Recent studies suggest that cAMP generated in the primary cilium drives cyst formation in ADPKD, indicating the cilium is an independent compartment for cAMP signaling. The localization of GPCRs in the ciliary membrane determines their downstream function, and optogenetic tools have contributed to establish the role of cAMP in cystogenesis.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yohann Rautureau, Marianne Berlatie, Daniel Rivas, Kurunradeth Uy, Alexandre Blanchette, Geraldine Miquel, Marie-Eve Higgins, Melanie Mecteau, Audrey Nault, Louis Villeneuve, Veronique Lavoie, Gabriel Theberge-Julien, Genevieve Brand, Line Lapointe, Maxime Denis, Camille Rosa, Annik Fortier, Lucie Blondeau, Marie-Claude Guertin, Marie-Pierre Dube, Eric Thorin, Jonathan Ledoux, David Rhainds, Eric Rheaume, Jean-Claude Tardif
Summary: ADCY9 gene plays a role in determining atherosclerotic outcomes in patients and in mice it has been shown to potentiate endothelial function and inhibit atherogenesis. The inactivation of Adcy9 leads to increased cAMP accumulation in response to certain activators and enhances endothelial-dependent vasodilation. Additionally, ADCY9 can regulate endothelial permeability and actin cytoskeleton in response to thrombin, affecting the development of atherosclerosis.
CARDIOVASCULAR RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Zhan-Bin Sun, Shu-Fan Yu, Chu-Lun Wang, Ling Wang
Summary: This review discusses the functions and applications of the cAMP signaling pathway in biocontrol fungi and proposes future research suggestions.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Physiology
Anastasiia Sholokh, Enno Klussmann
Summary: The compartmentalization of cAMP is tightly controlled by specific proteins, and its dysregulation is associated with CKD. Overactivation of the AVP system is linked to kidney damage and CKD. cAMP signaling plays important roles in podocytes and immune cells, slowing the progression of inflammatory processes.
Review
Biochemistry & Molecular Biology
Anna Signorile, Anna Ferretta, Maddalena Ruggieri, Damiano Paolicelli, Paolo Lattanzio, Maria Trojano, Domenico De Rasmo
Summary: Multiple sclerosis is a complex chronic disease involving the immune and central nervous systems, likely caused by the role of T lymphocytes in inflammation and tissue damage. Key factors such as cyclic AMP, mitochondrial dysfunction, and oxidative stress play important roles in the alteration of T lymphocytes homeostasis.
Article
Clinical Neurology
Jorryt G. Tichelaar, Ceyda Sayali, Rick C. Helmich, Roshan Cools
Summary: Tichelaar et al. investigated the impact of dopaminergic medication on reward learning in Parkinson's disease, specifically focusing on patients with impulse control disorders. They found that these patients were more sensitive to rewards when taking medication, and this sensitivity was associated with increased value signalling in the medial prefrontal cortex. The study also revealed individual differences in medication effects, suggesting that dopamine's effects on reinforcement learning vary depending on comorbid impulse control disorder and that they reflect deficits in value computation in the medial frontal cortex rather than in reward prediction error signalling in the striatum.
Article
Multidisciplinary Sciences
Juniorcaius Ikejezie, Tessa Langley, Sarah Lewis, Donal Bisanzio, Revati Phalkey
Summary: This study used GIS and spatial analysis to characterize the epidemiology of diphtheria in Haiti. The results showed spatial variability in diphtheria incidence, with positive associations with health facility density and degree of urbanization, and a negative association with female literacy. The findings provide a basis for future public health interventions to prevent and control diphtheria transmission.
Review
Biochemistry & Molecular Biology
Katherine R. Balka, Dominic De Nardo
Summary: The cGAS-STING pathway plays a crucial role in host defense against viral and bacterial infections by promoting the secretion of type I interferons and proinflammatory cytokines. Activation of key transcription factor IRF3 and NF-kappa B is mediated by the chief signaling receptor protein STING, which undergoes significant trafficking events across multiple subcellular locations. While studies have provided a comprehensive view of the regulation and role of the IRF3-IFN pathway downstream of STING, many aspects of STING signaling remain poorly defined.
Article
Biochemistry & Molecular Biology
Indrashis Bhattacharya, Souvik Sen Sharma, Hironmoy Sarkar, Alka Gupta, Bhola Shankar Pradhan, Subeer S. Majumdar
Summary: The study revealed differential transcriptional regulation of G alpha subunit genes in neonatal and pubertal rat Sertoli cells mediated by FSH-induced cAMP signaling. The increased expression of G alpha subunits in pubertal Sertoli cells may serve as a negative regulator to optimize cAMP production.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Nikolai P. Jaschke
Summary: Control loop designs in biology can have errors that may be fixed using generic strategies. Investigating loop designs in response to organismal stress helps to understand control theory as an organizing principle in biology, providing a broader perspective on endocrine and non-endocrine systems.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Neurosciences
Qing Cheng, Patricia Lamb, Korey Stevanovic, Briana J. Bernstein, Sydney A. Fry, Jesse D. Cushman, Jerrel L. Yakel
Summary: The study compared the responses of dentate granule cells and GABAergic interneurons to α7 nAChR agonists, revealing differential effects on intracellular signaling pathways possibly due to variations in Ca2+ regulation in different cell types. Additionally, in vivo observations showed enhanced neuronal activity in dentate granule cells but not in GABAergic neurons after nicotine administration, indicating a cell type-specific mechanism for α7 nAChR-mediated increase of neuronal activity.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Parisa Vahidi Ferdowsi, Kiran D. K. Ahuja, Jeffrey M. Beckett, Stephen Myers
Summary: In this study, the effect of capsaicin and zinc on glucose metabolism signalling pathways was evaluated. The results showed that both compounds activated calcium signalling, leading to increased glucose uptake in skeletal muscle cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Baijin Chang, Yanru Liu, Jingting Hu, Zhishu Tang, Zhidong Qiu, Zhongxing Song, Ailing Jia, Yuru Zhang
Summary: This study investigated the key targets and metabolites of the antidepressant effect of B. chinense based on the cAMP signalling pathway. The results showed that B. chinense significantly improved the depression symptoms in rats, and its antidepressant effect is primarily achieved by regulating the cAMP metabolic pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Nicoletta C. Surdo, Marco Berrera, Andreas Koschinski, Marcella Brescia, Matias R. Machado, Carolyn Carr, Peter Wright, Julia Gorelik, Stefano Morotti, Eleonora Grandi, Donald M. Bers, Sergio Pantano, Manuela Zaccolo
NATURE COMMUNICATIONS
(2017)
Editorial Material
Cardiac & Cardiovascular Systems
Susann Bruche, Manuela Zaccolo
CARDIOVASCULAR RESEARCH
(2018)
Article
Endocrinology & Metabolism
Alexander Hamilton, Quan Zhang, Albert Salehi, Mara Willems, Jakob G. Knudsen, Anna K. Ringgaard, Caroline E. Chapman, Alejandro Gonzalez-Alvarez, Nicoletta C. Surdo, Manuela Zaccolo, Davide Basco, Paul R. V. Johnson, Reshma Ramracheya, Guy A. Rutter, Antony Galione, Patrik Rorsman, Andrei I. Tarasov
Article
Chemistry, Analytical
Nshunge Musheshe, Miguel J. Lobo, Martina Schmidt, Manuela Zaccolo
Review
Pharmacology & Pharmacy
Nshunge Musheshe, Martina Schmidt, Manuela Zaccolo
TRENDS IN PHARMACOLOGICAL SCIENCES
(2018)
Article
Cell Biology
Peter T. Wright, Navneet K. Bhogal, Ivan Diakonov, Laura M. K. Pannell, Ruwan K. Perera, Nadja I. Bork, Sophie Schobesberger, Carla Lucarelli, Giuseppe Faggian, Anita Alvarez-Laviada, Manuela Zaccolo, Timothy J. Kamp, Ravi C. Balijepalli, Alexander R. Lyon, Sian E. Harding, Viacheslav O. Nikolaev, Julia Gorelik
Review
Biochemistry & Molecular Biology
Ying-Chi Chao, Nicoletta C. Surdo, Sergio Pantano, Manuela Zaccolo
BIOCHEMICAL SOCIETY TRANSACTIONS
(2019)
Article
Pharmacology & Pharmacy
Katharina Schleicher, Manuela Zaccolo
Summary: This review summarizes advanced imaging and proteomics techniques used to study compartmentalized cAMP signaling in eukaryotic cells, such as subcellularly targeted fluorescence resonance energy transfer sensors and proteomics analysis. The synergistic use of these techniques could potentially help in generating a detailed map of cAMP signalosomes and revealing new details of compartmentalized signaling.
MOLECULAR PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marcella Brescia, Ying-Chi Chao, Andreas Koschinski, Jakub Tomek, Manuela Zaccolo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Pharmacology & Pharmacy
Manuela Zaccolo, Anna Zerio, Miguel J. Lobo
Summary: Recent developments in the field of cAMP signaling have highlighted the importance of cAMP compartmentalization and the complex network through which cAMP signals propagate. Understanding the spatial regulation of cAMP levels and selective activation of signaling branches within the network is crucial for determining specific functional outcomes and potential disease mechanisms. This knowledge offers new insights into cell physiology and opens avenues for innovative therapeutic interventions.
PHARMACOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Milda Folkmanaite, Manuela Zaccolo
Summary: Cyclic adenosine monophosphate (cAMP) is a crucial intracellular messenger involved in cardiac function regulation. It forms nanodomains to match extracellular stimuli with appropriate cellular responses. Dysregulation of cAMP compartmentalization is associated with cardiovascular diseases.
BIOSCIENCE REPORTS
(2023)
Review
Biology
Jakub Tomek, Manuela Zaccolo
Summary: In the past 30 years, the understanding of cyclic adenosine 3',5'-monophosphate (cAMP) signaling has changed from a linear pathway to a complex network, where spatial regulation of cAMP plays a critical role. This new model provides novel insights into cardiac myocyte physiology and provides a framework for identifying disease mechanisms, particularly in the regulation of cardiac rhythm.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Alice Varley, Andreas Koschinski, Mark R. Johnson, Manuela Zaccolo
Summary: Preterm birth is a major cause of childhood mortality and morbidity. Understanding the role of cAMP signaling in controlling myometrial contractility is crucial for reducing the adverse outcomes associated with dysfunctional labor. This study used genetically encoded cAMP reporters to investigate cAMP signaling in human myometrial smooth muscle cells. The findings showed significant differences in the dynamics of cAMP response in different cellular compartments, and also highlighted the importance of cell model choice and culture conditions when studying cAMP signaling in myometrial cells.
Review
Biochemistry & Molecular Biology
Duangnapa Kovanich, Teck Yew Low, Manuela Zaccolo
Summary: cAMP is a second messenger that plays a crucial role in regulating cellular functions. The compartmentalization of cAMP signaling is essential for its specificity, and the formation of dynamic signaling domains is responsible for precise spatiotemporal regulation. Proteomics can be used to identify the components of these domains and define the dynamic landscape of cellular cAMP signaling. Understanding compartmentalized cAMP signaling in physiological and pathological conditions can provide insights into disease mechanisms and guide the development of precision medicine interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Stefania Monterisi, Manuela Zaccolo
BIOCHEMICAL SOCIETY TRANSACTIONS
(2017)
