Article
Veterinary Sciences
Daniel Aguilar-Garcia, J. Andres Fernandez-Sarmiento, Maria del Mar Granados Machuca, Juan Morgaz Rodriguez, Pilar Munoz Rascon, Rocio Navarrete Calvo, Yolanda Millan Ruiz, Jose Maria Carrillo Poveda, Juan Munoz Castaneda, Ramon Cugat Bertomeu, Juan Manuel Dominguez Perez
Summary: The purpose of this study was to evaluate the influence of plasma rich in growth factors (PRGF) on muscle regeneration after a surgically induced muscle injury. The results showed that PRGF treatment reduced inflammation, increased centrally nucleated fibers and decreased fibrosis. Additionally, PRGF treatment led to lower vascular density and smaller capillaries cross-sectional area. Biochemical analysis revealed higher expression level of MYOD1, MYF5 and MYOG genes in the PRGF group. Ultrastructural observations demonstrated less edema and loss of connective tissue structure, as well as higher mitochondrial density in the PRGF group compared to the control group.
BMC VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chaofan Jin, Kai Yan, Mengya Wang, Weihao Song, Xiangfu Kong, Zhengrui Zhang
Summary: In this study, the expression patterns of 24 FGF genes were identified and characterized in different tissues of embryonic and adult black rockfish specimens. Nine FGF genes were found to be essential for myoblast differentiation, muscle development, and recovery in juvenile black rockfish. Furthermore, multiple FGF genes showed sex-biased expression patterns during gonad development, with FGF1 gene promoting germ-cell proliferation and differentiation in the testes. These findings provide a systematic and functional characterization of FGF genes in the black rockfish and lay a foundation for future studies on FGF genes in other large teleost fishes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Robert H. Mak, Sujana Gunta, Eduardo A. Oliveira, Wai W. Cheung
Summary: Cachexia associated with chronic kidney disease (CKD) is linked to growth hormone (GH) resistance. This study found that GH treatment improved metabolism, food intake, weight growth, and muscular function in CKD mice. GH also decreased lipolysis, reversed adipose tissue browning, and normalized molecular markers of muscle wasting. Additionally, GH restored aberrant expression of muscle genes associated with thermogenesis, fibrosis, and regeneration. These findings suggest that GH may be an effective treatment for CKD-related cachexia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Xiaobo Pan, Pingzhang Yu, Zhengping Wang, Fapeng Yu, Xinguang Xu
Summary: A good quality single crystal of Tm3+ doped YPO4 crystal was grown using a lead or molybdenum free flux. The crystal's spectroscopic properties were investigated, revealing a large absorption cross-section at 791 nm and a strong emission cross-section at 1802 nm. These results suggest that the Tm3+:YPO4 crystal holds potential as a laser medium.
Article
Endocrinology & Metabolism
Athan G. Dial, Cynthia M. F. Monaco, Grace K. Grafham, Tirth P. Patel, Mark A. Tarnopolsky, Thomas J. Hawke
Summary: The study revealed that the decline in maximal muscle contraction was faster in individuals with type 1 diabetes after the age of 35, accompanied by morphological changes associated with accelerated aging. Additionally, there were differences in muscle fiber composition, including levels of fiber grouping and hybrid fibers, between genders in diabetes patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Geriatrics & Gerontology
Olivier Le Bacquer, Jerome Salles, Fabiana Piscitelli, Phelipe Sanchez, Vincent Martin, Christophe Montaurier, Vincenzo Di Marzo, Stephane Walrand
Summary: Sarcopenia in old rats is characterized by a significant decrease in muscle mass and function, associated with alterations in endocannabinoid levels in plasma, skeletal muscle, and adipose tissue. The findings suggest that changes in endocannabinoid tone are linked to sarcopenia, and OEA levels in plasma may be a potential biomarker for skeletal muscle function and loss of locomotor activity.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Xiaoyan Chen, Lingling Xie, Xin Xia, Xiaozhen Luo, Jing Chen, Jing Zhang, Qinlan Li, Xuemei Zhang, Jiaojiao Jiang, Ming Yang
Summary: Both measurement protocols and repetitions significantly affect the maximal handgrip strength values, but have minimal impact on the identification of handgrip weakness.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Maria D. Ayala, Victoria Gomez, Isabel Cabas, Maria P. Garcia Hernandez, Elena Chaves-Pozo, Marta Arizcun, Daniel Garcia de la Serrana, Francisco Gil, Alfonsa Garcia-Ayala
Summary: This study found that EE2 and G1 have negative effects on the growth, muscle parameters, and expression of growth-related genes in seabreams, resulting in hypertrophy of white fibers and abnormal expression of key genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Marc Sim, Jack Dalla Via, David Scott, Wai H. Lim, Jonathan M. Hodgson, Kun Zhu, Robin M. Daly, Gustavo Duque, Richard L. Prince, Joshua R. Lewis
Summary: The study found that women with low Cr:Cyc had weaker grip strength, worse performance in the timed-up-and-go test, and lower appendicular lean mass adjusted for height or body mass index. They also had a higher risk of falls and fall-related hospitalizations compared to women with high Cr:Cyc.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xuejie Wang, Ana Balana-Corbero, Juana Martinez-Llorens, Liyun Qin, Yingchen Xia, Jianhua Zha, Jose Maria Maiques, Esther Barreiro
Summary: In patients with bronchiectasis, both respiratory and peripheral muscle function are significantly impaired, with a greater impact on female patients than males of the same age and disease severity. In addition, body composition and blood biomarkers also differ between male and female patients. This highlights the importance of targeted therapeutics and comprehensive clinical assessment for these patients.
Article
Biochemistry & Molecular Biology
Marcio Vinicius Damico, Cristiane Damas Gil, Rosely Oliveira Godinho, Enio Setsuo Arakaki Pacini, Consuelo Latorre Fortes -Dias, Vanessa Moreira
Summary: The inhibition of 5-LOX and 12-LOX pathways can promote the regeneration of skeletal muscle fibers. Oral treatment with 5-LOX inhibitor MK886 or 12-LOX inhibitor baicalein can reduce inflammation and facilitate the healing process of muscle injury. Inhibition of the 5-LOX pathway enhances muscle resistance, while inhibition of the 12-LOX pathway promotes early recovery of muscle fiber activity and function.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
W. David Arnold, Brian C. Clark
Summary: Sarcopenia, or age-related decline in muscle form and function, has significant personal, societal, and economic burdens. The neuromuscular junction (NMJ), as the nexus between the nervous and muscular systems, plays a critical role in muscle force generation. While NMJ changes have been extensively studied in aged rodents, the presence of NMJ changes in older humans remains controversial. This review article discusses the physiological processes of NMJ transmission, the potential contribution of NMJ transmission failure to sarcopenia, and the possibility of targeting these defects for therapeutic development.
AGEING RESEARCH REVIEWS
(2023)
Article
Materials Science, Ceramics
Vuk Uskokovic, Nenad Ignjatovic, Sreco Skapin, Dragan P. Uskokovic
Summary: Hydroxyapatite (HAp) is a major component of bone tissues in mammals, and possesses exceptional biocompatibility. This study reports the synthesis and characterization of HAp doped with germanium ions for the first time. The doping of germanate ions into HAp altered its crystal lattice, leading to reduced crystallinity and increased microstrain. Additionally, the inclusion of germanate ions improved the particle size and morphology of HAp, and enhanced its surface charge density. Overall, doping HAp with germanate ions facilitated the production of nanorods with enhanced structural disorder and potential biomedical applications.
CERAMICS INTERNATIONAL
(2022)
Article
Cell Biology
Shir Lynn Lim, Xiao Liu, Qi Gao, Shwe Zin Nyunt, Lingli Gong, Josephine B. Lunaria, Carolyn S. P. Lam, Arthur Mark Richards, Shiou Liang Wee, Lieng Hsi Ling, Tze Pin Ng
Summary: Frailty in older adults is associated with subclinical vasculopathy, with carotid intima-media thickness showing a significant correlation with gait speed. The relationship between subclinical vasculopathy and muscle mass/function is modified by age and sex, with stronger associations found in those aged 70 and above. Further evaluation of mediating pathways is warranted.
Article
Chemistry, Multidisciplinary
Chunyi Huang, Didem Dede, Nicholas Morgan, Valerio Piazza, Xiaobing Hu, Anna Morral, Lincoln J. Lauhon
Summary: Selective area epitaxy is a promising method for defining nanowire networks in topological quantum computing. A strategy to promote Si dopant incorporation and suppress dopant diffusion in remote doped InGaAs nanowires templated by GaAs nanomembrane networks is reported. The growth of a dilute AlGaAs layer after doping the GaAs nanomembrane leads to the incorporation of Si, enabling precise control of the spacing between the Si donors and the undoped InGaAs channel; a simple model captures the influence of Al on the Si incorporation rate. Finite element modeling confirms the presence of high electron density in the channel.
Article
Sport Sciences
Christoph Triska, James Hopker, Barbara Wessner, Astrid Reif, Harald Tschan, Bettina Karsten
Summary: The study found no significant difference in assessing the parameters of the power-duration relationship between the 30-min rest protocol and the multivisit protocol. Except for VO2 amplitude, VO2 onset, NIRS tau, NIRS amplitude, blood lactate concentration, and maximal heart rate, there were no significant differences in other parameters between the two protocols.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Nutrition & Dietetics
Nicola A. Gillies, Bernhard Franzke, Barbara Wessner, Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Anela Tosevska, Eva-Maria Strasser, Nicole C. Roy, Amber M. Milan, David Cameron-Smith, Karl-Heinz Wagner
Summary: The study found that choline metabolites such as choline, betaine, and dimethylglycine play a central role in the co-regulation of 1C metabolism and cardiometabolic health in older adults. Additionally, changes in some metabolites were associated with improvements in lipid metabolism.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Nutrition & Dietetics
Ermira Krasniqi, Arben Boshnjaku, Karl-Heinz Wagner, Barbara Wessner
Summary: The association between vitamin D level and muscle-related traits is influenced by genetic, environmental, and nutritional factors. This review systematically identifies the relationship between SNPs in vitamin D pathway-related genes with vitamin D levels and muscle traits in healthy adults. It provides valuable information for selecting candidate SNPs for further studies and personalized strategies in identifying individuals at risk for vitamin D deficiency.
Article
Environmental Sciences
Arben Boshnjaku, Ermira Krasniqi, Harald Tschan, Barbara Wessner
Summary: The study on Kosovan adults shows that the ACTN3 R577X polymorphism may have a sex-specific impact on knee extensor peak torque and BMI. Female XX carriers exhibited taller height and higher isokinetic knee extension peak torque, while male XX carriers showed taller height and lower BMI compared to other groups.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Physiology
Astrid Reif, Barbara Wessner, Patricia Haider, Harald Tschan, Christoph Triska
Summary: This study investigated the effects of oral contraceptive pills on the knee-extensor and flexor strength performance of female first division team athletes. The results showed no significant differences in strength performance between different phases of the oral contraceptive cycle, suggesting that OCP intake leads to a stable but downregulated hormone cycle without affecting strength performance.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Arben Boshnjaku, Abedin Bahtiri, Kaltrina Feka, Ermira Krasniqi, Harald Tschan, Barbara Wessner
Summary: This study reports the test-retest reliability data of laboratory-and field-based performance tests and body composition analyses of younger and older Kosovan adults. The results show that younger participants outperformed older participants in performance tests and body composition, with high reliability of the parameters observed in both age groups.
Article
Nutrition & Dietetics
Rudolf Aschauer, Sandra Unterberger, Patrick A. Zoehrer, Agnes Draxler, Bernhard Franzke, Eva-Maria Strasser, Karl-Heinz Wagner, Barbara Wessner
Summary: Vitamin D3 supplementation does not have additive effects on muscle strength and performance in older adults during resistance training. However, it can improve vitamin D status. Resistance training positively affects muscle endurance and arm curl test.
Article
Nutrition & Dietetics
Sandra Unterberger, Rudolf Aschauer, Patrick A. Zoehrer, Agnes Draxler, Bernhard Franzke, Eva-Maria Strasser, Karl-Heinz Wagner, Barbara Wessner
Summary: The study aimed to evaluate the feasibility of increasing protein intake in older adults through dietary supplementation and determine whether this increase would lead to greater improvements when combined with resistance training. The results showed that a substantial increase in protein intake was achievable within 17 weeks in community-living elderly individuals. However, the additional protein intake had minor effects on body composition and did not impact physical performance or muscle quality.
CLINICAL NUTRITION
(2022)
Article
Rehabilitation
Eva M. Strasser, Bernhard Franzke, Marlene Hofmann, Barbara Schober-Halper, Stefan Oesen, Waltraud Jandrasits, Alexandra Graf, Martin Ploder, Norbert Bachl, Michael Quittan, Karl-Heinz Wagner, Barbara Wessner
Summary: In institutionalized elderly individuals, six months of resistance training with or without nutritional supplementation did not alter muscle thickness of the quadriceps, but baseline values and health status significantly influenced the training effect. Further studies may focus on individualizing training regimes based on accompanying diseases and medications in this population.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Astrid Reif, Markus Hackl, Alfred Nimmerichter, Stefan Oesen, Harald Tschan, Norbert Bachl, Christoph Triska, Barbara Wessner
Summary: This pilot study shows that using cycle ergometers as an intervention in schools can improve children's aerobic capacity, but has no impact on body composition and most blood parameters.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Annette Brandt, Anja Baumann, Angelica Hernandez-Arriaga, Finn Jung, Anika Nier, Raphaela Staltner, Dragana Rajcic, Christian Schmeer, Otto W. Witte, Barbara Wessner, Bernhard Franzke, Karl-Heinz Wagner, Amelia Camarinha-Silva, Ina Bergheim
Summary: Aging is associated with low grade inflammation, called "inflammaging". Maintaining intestinal homeostasis may help extend the healthy status of older adults. In this study, it was found that even in healthy older men, low grade bacterial endotoxemia is common. Additionally, while intestinal microbiota composition changes significantly during aging, fecal microbiota transplantation does not protect against aging-associated intestinal barrier dysfunction in mice.
Article
Medicine, General & Internal
Arben Boshnjaku, Abedin Bahtiri, Kaltrina Feka, Ermira Krasniqi, Harald Tschan, Barbara Wessner
Summary: This study aimed to explore sarcopenia in mature Kosovans and its impact on health and socio-economic parameters. The findings suggest that sarcopenia may differ between populations, age groups, and sexes, and may be underestimated in obese individuals. Age, body composition, physical performance, health, and socio-economic conditions can influence the occurrence of sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Bernhard Franzke, Andrea Bileck, Sandra Unterberger, Rudolf Aschauer, Patrick A. Zoehrer, Agnes Draxler, Eva-Maria Strasser, Barbara Wessner, Christopher Gerner, Karl-Heinz Wagner
Summary: The study aimed to compare the effects of habitual diet, recommended protein intake, and high protein intake combined with strength training on the plasma proteome in older adults. The results showed that the high protein diet and strength training led to improvements in body composition, and the high protein diet had beneficial effects on the innate immune system, lipid transport, and blood coagulation system.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Sandra Unterberger, Rudolf Aschauer, Patrick A. Zoehrer, Agnes Draxler, Mirjam Aschauer, Benno Kager, Bernhard Franzke, Eva-Maria Strasser, Karl-Heinz Wagner, Barbara Wessner
Summary: In recent years, the phase angle (PhA) has been studied as a variable to assess cell integrity and physical performance. However, there is limited data on healthy older adults. This retrospective analysis examined the relationship between PhA, body composition, physical performance, and macronutrient intake in older adults and found that PhA was associated with physical performance but not protein intake. Age, sex, BMI, and PhA were predictors of performance test outcomes.
Article
Biochemistry & Molecular Biology
Agnes Draxler, Bernhard Franzke, Sanja Kelecevic, Alexander Maier, Jelena Pantic, Simon Srienc, Katharina Cellnigg, Scoris-Marian Solomon, Carina Zoetsch, Rudolf Aschauer, Sandra Unterberger, Patrick A. Zoehrer, Laura Bragagna, Eva-Maria Strasser, Barbara Wessner, Karl-Heinz Wagner
Summary: The main goal of this intervention study was to investigate the effect of different vitamin D supplementation strategies on chromosomal stability in older individuals. Walking distance and chair stand performance improved, but vitamin D supplementation did not increase the frequency of chromosomal anomalies.
