Article
Medicine, Research & Experimental
Georg Karl Ludwig Burghardt, Mandy Cuevas, Rumi Sekine, Thomas Hummel
Summary: This study compared nasal trigeminal sensitivity in patients with allergic rhinitis (AR), chronic rhinosinusitis with nasal polyps (CRSwNP), and healthy controls (HC). The results showed that AR patients had increased sensitivity to trigeminal stimuli, while CRSwNP patients had decreased sensitivity.
Article
Immunology
Li Li, Yuanding Zhang, Hong Liu, Tianqi Wang, Junxin Li, Xin Wang
Summary: This Mendelian Randomization (MR) study aims to evaluate the causal relationships between 41 inflammatory cytokines and the incidence of Allergic Rhinitis (AR), Chronic Rhinosinusitis (CRS), and Nasal Polyps (NP). The results showed that elevated levels of MIP-1 alpha and TNF-alpha were associated with an increased risk of AR, while elevated levels of IL-2 were associated with an increased susceptibility to NP. Furthermore, increased levels of circulating PDGF-BB were linked to a reduced risk of NP. However, there was no positive association found between levels of inflammatory cytokines and the incidence of CRS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Otorhinolaryngology
Weigang Gan, Fengjuan Yang, Juan Meng, Feng Liu, Shixi Liu, Junming Xian
Summary: The microbiome of the nasal cavity and its contribution to nasal mucosal disease have been poorly understood. This study used molecular methods to characterize the microbiome and found that certain microbial populations were significantly different in allergic rhinitis and chronic rhinosinusitis, suggesting a role of microbial dysbiosis in the pathogenesis of nasal mucosal inflammation.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Review
Otorhinolaryngology
Rachel A. Schusteff, Margaret A. Chervinko, Sharmilee M. Nyenhuis, Victoria S. Lee
Summary: This study examined the use of ecological momentary assessment (EMA) in allergic rhinitis (AR) and chronic rhinosinusitis (CRS). It found that there have been few studies using EMA in AR and no studies in CRS. EMA has the potential to capture real-time data and provide a better understanding of the relationship between environmental triggers and symptoms, guiding treatment decisions.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Otorhinolaryngology
Aysegul Tuna, Burak M. Tas, Gokben Basaran Kankilic, Furkan M. Kocak, Ziya Sencan, Ela Comert, Nuray Bayar Muluk, Birguel Kacmaz, Serdar Gul, Eftal Boeke
Summary: This study investigated the relationship between microplastics, a global health and environmental issue, and allergic rhinitis. The findings showed that allergic rhinitis patients had significantly higher levels of microplastics in their nasal lavage fluids compared to the control group.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yara Zoabi, Francesca Levi-Schaffer, Ron Eliashar
Summary: Allergic rhinitis is a common nasal disorder affecting up to 30% of adults. Mast cells play a crucial role in allergic inflammation and are involved in the development of symptoms. This review provides a comprehensive summary of mast cells' involvement in allergic rhinitis and the modulation of mast cells by current and emerging therapies.
Article
Otorhinolaryngology
Qiqi Luo, Siyi Zhou, Bo Yuan, Zeli Feng, Guolin Tan, Honghui Liu
Summary: This study analyzed blood parameter differences between patients with allergic rhinitis (AR) and nonallergic rhinitis (NAR), with or without chronic rhinosinusitis (CRS). The results showed that blood eosinophil count and proportion may be good diagnostic predictors of allergic-like rhinitis, but they cannot distinguish between AR and NAR. However, these indicators may be more effective in predicting allergic-like rhinitis with CRSwNP.
CLINICAL OTOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
V. Backer, K. Aanaes, S. Hansen, J. Petersen, C. von Buchwald
Summary: The researchers aimed to design a standardized test for the awareness of global airway diseases by developing a global airways questionnaire using a mix of clinical knowledge and data-driven methods. The questionnaire included three domains: allergic rhinitis, chronic rhinosinusitis, and asthma sub-factors.
Article
Otorhinolaryngology
Min-Seok Rha, Hyung-Ju Cho, Joo-Heon Yoon, Chang-Hoon Kim
Summary: This study found a significant association between the use of electronic cigarettes (ECs) and the prevalence of chronic rhinosinusitis (CRS) and allergic rhinitis (AR) in adults.
Review
Immunology
Harsha H. Kariyawasam, Louisa K. James
Summary: This article discusses the role of B cells in upper airway diseases, focusing on allergic rhinitis and chronic rhinosinusitis with nasal polyps. Despite the increasing understanding of B-cell dysfunction in these diseases, there is a lack of specific studies on B cells in relation to sinonasal infection and mucosal inflammation. Further research is needed to explore how respiratory inflammation and impaired B-cell function contribute to immune dysregulation in these conditions.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Review
Microbiology
Juanjuan Lyu, Fangfang Kou, Xiangyu Men, Yinhui Liu, Li Tang, Shu Wen
Summary: Complex changes in the microbiota of the respiratory and intestinal tracts in patients with allergic respiratory diseases are associated with immune disorders and could potentially be targeted for therapy.
Review
Otorhinolaryngology
David Grimm, Peter H. Hwang, Yi-Tsen Lin
Summary: Allergic rhinitis and chronic rhinosinusitis (CRS) are common disorders affecting millions of people worldwide. This review assesses the similarities and differences between patients with CRS and allergic rhinitis, with a focus on pathologic mechanisms, patient endotypes, genetics, and the nasoepithelial immunologic barrier. Understanding the relationship between allergic rhinitis and CRS is important for treatment options.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2023)
Article
Endocrinology & Metabolism
M. De Filippo, M. Votto, M. Benazzo, E. Gitto, A. Salpietro, F. Pagella, A. Licari, G. L. Marseglia
Summary: Chronic rhinosinusitis is a heterogeneous chronic inflammatory condition that requires a multidisciplinary approach for evaluation and treatment. Only two biologicals have been approved for severe CRS with nasal polyps in adults, and clinical trials for children and adolescents are needed to confirm their efficacy and safety.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Health Care Sciences & Services
Eugenio De Corso, Silvia Baroni, Stefano Settimi, Maria Elisabetta Onori, Rodolfo Francesco Mastrapasqua, Eliana Troiani, Giacomo Moretti, Donatella Lucchetti, Marco Corbo, Claudio Montuori, Alessandro Cantiani, Davide Paolo Porru, Simone Lo Verde, Giuseppe Alberto Di Bella, Cristiano Caruso, Jacopo Galli
Summary: This study evaluated the inflammatory load and cytokine profiles in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Two distinct clusters were identified based on cytokine levels and eosinophil count, with IL-5 being the most reliable biomarker for differentiation. This research highlights the potential role of type 2 biomarkers, particularly IL-5, in identifying patients with a more severe phenotype.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)