Article
Surgery
Bastian N. Ruijter, Maarten E. Tushuizen, Dirk J. A. R. Moes, Babs M. de Klerk, Bart van Hoek
Summary: This study evaluated the monitoring method of tacrolimus in stable liver transplant recipients, and found that 4-hour monitoring was not superior to trough monitoring in terms of its effect on renal function, but it was safe to use in an afternoon outpatient clinic.
CLINICAL TRANSPLANTATION
(2022)
Article
Biology
Brett D. Anderson, Erek D. Nelson, DongJin Joo, Bruce P. Amiot, Aleksandr A. Katane, Alyssa Mendenhall, Benjamin G. Steiner, Aron R. Stumbras, Victoria L. Nelson, R. Noelle Palumbo, Thomas W. Gilbert, Dominique S. Davidow, Jeffrey J. Ross, Scott L. Nyberg
Summary: Organ bioengineering provides a promising solution to the shortage of donor organs. Anderson et al. demonstrate a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver scaffold that had been previously reendothelialized, a significant advancement in generating transplantable livers of a clinically relevant size for humans.
COMMUNICATIONS BIOLOGY
(2021)
Article
Medicine, General & Internal
Richard Dumbill, Roderick Jaques, Matthew Robb, Rachel Johnson, Rutger J. Ploeg, Maria E. Kaisar, Edward J. Sharples
Summary: Through analysis of UK Transplant Registry data, this study finds that prolonged delayed graft function (DGF) is associated with adverse long-term outcomes, suggesting that alloimmunity may contribute to prolonged DGF by a mechanism distinct from typical early acute rejection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Mamatha Bhat, Madhumitha Rabindranath, Beatriz Sordi Chara, Douglas A. Simonetto
Summary: Liver transplantation (LT) is a life-saving treatment for end-stage liver disease, and artificial intelligence (AI) offers a data-driven approach to improve clinical decision-making in LT. AI can be applied in optimizing transplant candidacy decision-making, donor-recipient matching, and guiding the management of LT recipients. However, limitations such as dataset imbalances, data privacy issues, and a lack of research practices to benchmark model performance in the real world need to be addressed. Overall, AI has the potential to enhance personalized clinical decision-making in liver transplant medicine.
JOURNAL OF HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sara Assadiasl, Nuala Mooney, Mohammad Hossein Nicknam
Summary: Cytokines play crucial roles in autoimmune, allergic, and infectious diseases, as well as allograft rejection. Recent advances in novel anti-cytokine agents and gene therapy for immunomodulatory cytokines have shown significant improvements in managing dysregulated cytokine secretion and overexpression.
Article
Transplantation
Amelie K. Muller, Eva Breuer, Kerstin Hubel, Kuno Lehmann, Pietro Cippa, Thomas Schachtner, Christian Oberkofler, Thomas Muller, Markus Weber, Philipp Dutkowski, Pierre-Alain Clavien, Olivier de Rougemont
Summary: This study is the first to demonstrate similar graft survival and function in DCD kidneys compared with DBD kidneys after 35 years of follow-up. DCD grafts are a valuable resource and can be utilized in the same way as DBD grafts.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Critical Care Medicine
Michael R. Pinsky, Maurizio Cecconi, Michelle S. Chew, Daniel De Backer, Ivor Douglas, Mark Edwards, Olfa Hamzaoui, Glenn Hernandez, Greg Martin, Xavier Monnet, Bernd Saugel, Thomas W. L. Scheeren, Jean-Louis Teboul, Jean-Louis Vincent
Summary: Hemodynamic monitoring plays a crucial role in acute care settings, but its effectiveness is hard to measure. This review summarizes the effectiveness of monitoring-linked resuscitation strategies, including process-specific monitoring, personalized resuscitation approaches, and machine learning methods. Future clinical trials should focus on process-specific monitoring to improve patient outcomes.
Article
Medicine, General & Internal
Dennis Eurich, Stephan Schlickeiser, Ramin Raul Ossami Saidy, Deniz Uluk, Florian Rossner, Maximilian Postel, Wenzel Schoening, Robert Oellinger, Georg Lurje, Johann Pratschke, Petra Reinke, Natalie Gruen
Summary: This study presents a simple scoring system based on clinical parameters to estimate the probability of tolerance in liver transplant patients. The scoring system showed good predictive performance in assessing the clinical probability of tolerance or the dispensability of immunosuppressive drugs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Louise Barbier, Aurelie Robin, Remy Sindayigaya, Heloise Ducousso, Fanny Dujardin, Antoine Thierry, Thierry Hauet, Jean-Philippe Girard, Luc Pellerin, Jean-Marc Gombert, Andre Herbelin, Ephrem Salame
Summary: The study found that IL-33 plays a significant role in liver injury, as evidenced by experiments in mouse models and human liver transplant patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Khalil Aburahma, Jawad Salman, Bastian Engel, Florian W. R. Vondran, Mark Greer, Dietmar Boethig, Thierry Siemeni, Murat Avsar, Nicolaus Schwerk, Carsten Mueller, Richard Taubert, Marius M. Hoeper, Tobias Welte, Hans H. Wedemeyer, Nicolas Richter, Gregor Warnecke, Igor Tudorache, Axel Haverich, Christian Kuehn, Gerrit Grannas, Fabio Ius
Summary: A combined lung and liver transplant in patients with cystic fibrosis did not impair lung graft function, and the liver graft showed tolerogenic effects against rejection.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Immunology
Dan Wang, Yanling Ma, Baohong Gu, Xuemei Li, Yang Yu, Ying Zhang, Hao Chen
Summary: Dual-graft liver transplantation (DGLT) is a surgical method that expands the pool of donors, ensures donor safety, and treats small for size syndrome (SFSS). This study utilized a rat model to investigate the causes of growth unbalance after DGLT. The findings suggest that perfusion blood flow and apoptosis may contribute to the volume differences between the dual grafts.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Stan Benjamens, Saleh Z. Alghamdi, Elsaline Rijkse, Charlotte A. te Velde-Keyzer, Stefan P. Berger, Cyril Moers, Martin H. de Borst, Riemer H. J. A. Slart, Frank J. M. F. Dor, Robert C. Minnee, Robert A. Pol
Summary: This study showed a negative association between pre-transplant aorto-iliac calcification and one-year estimated GFR in univariate analysis, but not in multivariable analysis. Additionally, a high CaScore was associated with overall graft failure and death with a functioning graft in multivariable analysis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Joseba Salguero, Laura Chamorro, Enrique Gomez-Gomez, Patricia de Benito, Jose E. Robles, Juan P. Campos
Summary: Delayed graft function (DGF) development significantly contributes to graft loss in kidney transplants, particularly in grafts with KDRI >= 1.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Qinxia Xu, Yue Dong, Wanjie Niu, Xinyi Zheng, Ruidong Li, Ming Zhang, Zhengxin Wang, Xiaoyan Qiu
Summary: This study investigated the relationship between SNPs in TLR10 and the clinical outcomes of renal and liver transplant patients on tacrolimus treatment. The results showed that three SNPs in renal transplant recipients influenced graft function, and the recipient rs11096957 also affected bilirubin levels in liver transplant recipients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yongrong Ye, Fei Han, Maolin Ma, Qipeng Sun, Zhengyu Huang, Haofeng Zheng, Zhe Yang, Zihuan Luo, Tao Liao, Heng Li, Liangqing Hong, Ning Na, Qiquan Sun
Summary: The study found that intraoperative MIF levels are associated with DGF, offering excellent diagnostic performance for predicting DGF and warranting further exploration.
FRONTIERS IN MEDICINE
(2021)