Article
Chemistry, Multidisciplinary
Meng Qiu, Yanhong Duo, Weiyuan Liang, Yunlong Yang, Bin Zhang, Zhongjian Xie, Xiaoli Yang, Guiqing Wang, Ni Xie, Guohui Nie, Omar A. Alhartomy, Ahmed A. ALGhamdi, Swelm Wageh, Yihai Cao, Han Zhang
Summary: Most anticancer drugs are distributed unevenly in tumors, leading to severe adverse effects; Nanopoxia technology releases therapeutic agents based on tumor hypoxia, achieving precision cancer therapy; This approach demonstrates high efficacy in preclinical cancer models.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Maria Alexandra Angelescu, Octavian Andronic, Simona Olimpia Dima, Irinel Popescu, Irit Meivar-Levy, Sarah Ferber, Daniela Lixandru
Summary: Diabetes mellitus is a complex disease that requires early diagnosis and treatment to prevent complications. MiRNAs have shown promise as biomarkers for early detection and monitoring of the disease. Further research is needed to validate their effectiveness in diagnosing and treating diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Alina Nicheperovich, Andrea Townsend-Nicholson
Summary: This review suggests that detection of Smo variants through tumor profiling could lead to increased precision and improved outcomes of anti-cancer treatments.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Joaquin Mateo, Lotte Steuten, Philippe Aftimos, Fabrice Andre, Mark Davies, Elena Garralda, Jan Geissler, Don Husereau, Iciar Martinez-Lopez, Nicola Normanno, Jorge S. Reis-Filho, Stephen Stefani, David M. Thomas, C. Benedikt Westphalen, Emile Voest
Summary: Precision medicine is reshaping cancer care, but accessibility to all patients remains a challenge. This Perspective highlights the importance of addressing the challenges in implementing precision oncology, including equal access to genomics tests, robust evidence for new drugs and technologies, interpretation of genomics data by physicians, and empowering patients in shared decision-making.
Review
Chemistry, Multidisciplinary
Zheng Li, Jianhua Zou, Xiaoyuan Chen
Summary: Subcellular targeted cancer therapy has emerged as a potent anticancer treatment, providing great opportunities for clinical application. This review summarizes two targeting strategies for four main subcellular organelles, including molecule- and nanomaterial-based targeted delivery or therapeutic strategies. Various treatment strategies such as phototherapy, chemotherapy, radiotherapy, immunotherapy, and combination therapy are discussed in detail. The construction of specific materials based on the properties and mechanisms of organelles allows for the elimination of tumors by inducing dysfunction or destroying specific structures. The challenges faced by organelle-targeting cancer therapies are also summarized. A paradigm for organelle-targeting therapy with enhanced therapeutic efficacy is envisioned.
ADVANCED MATERIALS
(2023)
Review
Oncology
G. Middleton, H. Robbins, F. Andre, C. Swanton
Summary: Based on the results from several platform studies, it has been concluded that genotype-matched therapy is effective for cancer patients, but there are still challenges in combination therapy. Precision medicine holds great promise in cancer treatment, but more accurate models are needed to capture the genomic complexity of human diseases.
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Mario Hlevnjak, Markus Schulze, Shaymaa Elgaafary, Carlo Fremd, Laura Michel, Katja Beck, Katrin Pfuetze, Daniela Richter, Stephan Wolf, Peter Horak, Simon Kreutzfeldt, Constantin Pixberg, Barbara Hutter, Naveed Ishaque, Steffen Hirsch, Laura Gieldon, Albrecht Stenzinger, Christoph Springfeld, Katharina Smetanay, Julia Seitz, Athanasios Mavratzas, Benedikt Brors, Romy Kirsten, Florian Schuetz, Stefan Froehling, Hans-Peter Sinn, Dirk Jaeger, Verena Thewes, Marc Zapatka, Peter Lichter, Andreas Schneeweiss
Summary: PURPOSE CATCH is a precision oncology program that utilizes genomics and transcriptomics to guide therapeutic decisions in the clinical management of metastatic breast cancer. Among the first 200 enrolled patients, half of them were treated according to the recommendations of the molecular tumor board and showed clinical benefit during treatment.
JCO PRECISION ONCOLOGY
(2021)
Review
Immunology
Fangmin Zhao, Rui Yu, Shuyi Chen, Shuya Zhao, Lin Sun, Zeting Xu, Yao Zhang, Shuying Dai, Gaochenxi Zhang, Qijin Shu
Summary: This study provides a comprehensive evaluation of the literature output and trends in research on precision cancer medicine-related rashes from a global perspective. The results show that the number of publications in this field has been increasing annually, with the United States being the leading contributor. Checkpoint inhibitors and skin adverse events are emerging research hotspots in recent years.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Cell Biology
James Kim, John D. Minna
Summary: In this study, Wang et al. generated 160 human lung cancer organoids from malignant effusions and tested their response to clinically used drugs, aiming to predict patient responses.
CELL REPORTS MEDICINE
(2023)
Review
Oncology
Kazuma Kiyotani, Yujiro Toyoshima, Yusuke Nakamura
Summary: The significant advances in cancer genomics have allowed for precision medicine based on genomic and molecular profiling, but clinical application still faces challenges. Cancer immunotherapies, particularly targeting neoantigens derived from somatic mutations, offer potential for precise treatment based on genomic sequencing results.
CANCER BIOLOGY & MEDICINE
(2021)
Review
Immunology
Jean-Francois Rossi, Zhao Yang Lu, Cesare Massart, Kalle Levon
Summary: Normal or good inflammation is initiated by local cellular responses against injury or infection, followed by amplification of the process with the migration of immune cells and eventually leading to healing. Systemic inflammation mobilizes additional cells from the immune system, while local mechanisms limit inflammation and promote healing.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fabio Pastorino, Mario Capasso, Chiara Brignole, Serena Giglio, Veronica Bensa, Sueva Cantalupo, Vito Alessandro Lasorsa, Annalisa Tondo, Rossella Mura, Angela Rita Sementa, Alberto Garaventa, Mirco Ponzoni, Loredana Amoroso
Summary: Neuroblastoma is the most common extracranial solid tumor in childhood. The prognosis for patients with metastatic relapse or refractory disease is poor. The integration of genome sequencing into standard clinical practice is necessary for personalized therapy. In this study, whole exome sequencing was performed on two patients with relapsed NB, and actionable genetic variations were identified and treated accordingly. The results demonstrate the feasibility of incorporating clinical WES into pediatric oncology practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yeuan Ting Lee, Yi Jer Tan, Chern Ein Oon
Summary: Cancer is a major global cause of death and a continuing threat to human health. Drug resistance is a significant challenge in cancer treatment, and developing new drugs targeting malignant cells is a high priority. Benzimidazole and its derivatives have shown potential as anticancer therapeutics through various mechanisms, making them an important focus in medicinal chemistry and biology. This review provides updates on the mechanisms and structure-activity relationships of benzimidazole derivatives, from conventional anticancer treatments to precision healthcare. (c) 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Oncology
Fortunato Ciardiello, Davide Ciardiello, Giulia Martini, Stefania Napolitano, Josep Tabernero, Andres Cervantes
Summary: This review summarizes the progress in the clinical management of patients with metastatic colorectal cancer (mCRC) in the era of precision medicine. Molecular stratification, based on the current treatment algorithm, has been a significant step towards implementing more effective therapeutic approaches. Integrating tumor gene alterations with tumor and microenvironment gene and protein expression profiling, host immune competence, and applying dynamic changes to precision medicine-based continuum of care, could lead to the identification of individual prognostic and predictive parameters for choosing the most appropriate therapeutic program for each patient.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Review
Biochemistry & Molecular Biology
Sahithi Pamarthy, Hatem E. Sabaawy
Summary: Advancements in utilizing patient derived organoids (PDOs) for modeling prostate cancer have shown promise in predicting therapeutic responses and screening effective targeted therapies. Technological innovations in generating PDOs and incorporating various extracellular matrices have improved the accuracy and reliability of these models. PDOs, especially those derived from single cells, accurately represent the molecular features of the original tumor and serve as a reliable pre-clinical model for understanding individual tumors and designing tailored targeted therapies.
