New molecular insights into osteosarcoma targeted therapy

Recurrent RECQL4 Imbalance and Increased Gene Expression Levels Are Associated with Structural Chromosomal Instability in Sporadic Osteosarcoma

(2015) Georges Maire et al.   NEOPLASIA

APEX1 Gene Amplification and Its Protein Overexpression in Osteosarcoma: Correlation with Recurrence, Metastasis, and Survival

(2014) Jilong Yang et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells

(2012) Zan Chen et al.   ACTA PHARMACOLOGICA SINICA

Alternate Splicing of the p53 Inhibitor HDMX Offers a Superior Prognostic Biomarker than p53 Mutation in Human Cancer

(2012) Kristiaan Lenos et al.   CANCER RESEARCH

miRNA Signatures Associate with Pathogenesis and Progression of Osteosarcoma

(2012) K. B. Jones et al.   CANCER RESEARCH

Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling

(2012) Yonggang Li et al.   FEBS Journal

Exploration of a new drug that targets YAP

(2012) M. Fujii   JOURNAL OF BIOCHEMISTRY

HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis

(2012) Dan Liang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway

(2012) Annamaria Spina et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Phase II Trial of Trastuzumab in Combination With Cytotoxic Chemotherapy for Treatment of Metastatic Osteosarcoma With Human Epidermal Growth Factor Receptor 2 Overexpression: A Report From the Children's Oncology Group

(2012) David Ebb et al.   JOURNAL OF CLINICAL ONCOLOGY

miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3

(2011) Li-hong Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, includingVEGFA, in human osteosarcoma

(2011) Jilong Yang et al.   CANCER

Cell surface receptor expression patterns in osteosarcoma

(2011) Sheref E. Hassan et al.   CANCER

Thrombin induces osteosarcoma growth, a function inhibited by low molecular weight heparin in vitro and in vivo

(2011) Jiro Ichikawa et al.   CANCER

Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma

(2011) Takanao Sueyoshi et al.   CANCER LETTERS

HMGB1 Promotes Drug Resistance in Osteosarcoma

(2011) J. Huang et al.   CANCER RESEARCH

P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma

(2011) Daria Brambilla et al.   INTERNATIONAL JOURNAL OF CANCER

A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription

(2011) Y. Bao et al.   JOURNAL OF BIOCHEMISTRY

CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis

(2011) Olivia Fromigue et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression

(2011) Mitsuhiko Osaki et al.   MOLECULAR THERAPY

Clinical value of signal transducers and activators of transcription 3 (STAT3) gene expression in human osteosarcoma

(2010) Yu-Cai Wang et al.   ACTA HISTOCHEMICA

Functional and biological analysis of Bcl-xL expression in human osteosarcoma

(2010) Zhao-Xia Wang et al.   BONE

High Wnt Signaling Represses the Proapoptotic Proteoglycan syndecan-2 in Osteosarcoma Cells

(2010) F.-X. Dieudonne et al.   CANCER RESEARCH

Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells

(2010) Bo Song et al.   Molecular Cancer

c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis

(2010) T Shimizu et al.   ONCOGENE

Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness

(2010) P Zhang et al.   ONCOGENE

IKK  protein is a target of BAG3 regulatory activity in human tumor growth

(2010) M. Ammirante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of the E2F1-Driven Cancer Cell Fate by the DNA Damage Response Machinery and Potential Novel E2F1 Targets in Osteosarcomas

(2009) Michalis Liontos et al.   AMERICAN JOURNAL OF PATHOLOGY

Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma

(2009) Jilong Yang et al.   CANCER LETTERS

Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets in Human Osteosarcoma

(2009) S. Avnet et al.   CANCER RESEARCH

Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma

(2009) Kazuhito Morioka et al.   CANCER SCIENCE

Functional genome screen for therapeutic targets of osteosarcoma

(2009) Umio Yamaguchi et al.   CANCER SCIENCE

The kinase Mirk is a potential therapeutic target in osteosarcoma

(2009) C. Yang et al.   CARCINOGENESIS

Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics

(2009) Annette S. Gillings et al.   FEBS Journal

The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines

(2009) Jennifer K. McCleese et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular characterization of the response to chemotherapy in conventional osteosarcomas: Predictive value of HSD17B10 and IFITM2

(2009) Sébastien Salas et al.   INTERNATIONAL JOURNAL OF CANCER

Inactive Wnt/β-catenin pathway in conventional high-grade osteosarcoma

(2009) Yongping Cai et al.   JOURNAL OF PATHOLOGY

Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells

(2009) Yin-He Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Bim-targeted cancer therapy: A link between drug action and underlying molecular changes

(2009) T. Akiyama et al.   MOLECULAR CANCER THERAPEUTICS

Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling

(2009) M Enomoto et al.   ONCOGENE

Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin

(2009) X Wan et al.   ONCOGENE

Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway

(2008) T. Akiyama et al.   MOLECULAR CANCER THERAPEUTICS