Article
Multidisciplinary Sciences
Akiko Miki, Sentaro Kusuhara, Tsuyoshi Otsuji, Yu Kawashima, Katsuaki Miki, Hisanori Imai, Makoto Nakamura, Akitaka Tsujikawa
Summary: This study suggests that a combination of photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) therapy can significantly improve visual acuity and reduce choroidal and retinal thickness in patients with pachychoroid neovasculopathy (PNV) in the short term, with effects maintained for up to 12 months.
Article
Biochemistry & Molecular Biology
Yan Wang, Jiahui Ni, Aiyu Wang, Run Zhang, Linjie Wang
Summary: This study found that VEGFA regulates glycolipid metabolism in Schizothorax prenanti through AMPK alpha, contributing to a better understanding of the functions of VEGFA in fish glycolipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Pinelopi Kastana, Despoina Ntenekou, Eleni Mourkogianni, Michaela-Karina Enake, Athanasios Xanthopoulos, Effrosyni Choleva, Antonia Marazioti, Sophia Nikou, Racheal G. Akwii, Eleni Papadaki, Esther Gramage, Gonzalo Herradon, Georgios T. Stathopoulos, Constantinos M. Mikelis, Evangelia Papadimitriou
Summary: This study reveals the important role of PTPRZ1 in lung adenocarcinoma growth and angiogenesis. PTPRZ1 is expressed in endothelial cells and required for cell migration by VEGFA and PTN stimulation.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Menglu Zhang, Jiaqi Liu, Gang Liu, Zeyu Xing, Ziqi Jia, Jiaxin Li, Wenyan Wang, Jie Wang, Ling Qin, Xin Wang, Xiang Wang
Summary: Breast cancer, the highest incidence of female malignancy, is heavily reliant on neo-vascularization for growth and metastasis, with Vascular Endothelial Growth Factor (VEGF) playing a crucial role. This review focuses on the prognostic value of VEGF in breast cancer, clinical experiences with anti-VEGF therapeutics, and biomarkers for predicting the effectiveness of anti-angiogenic treatment.
Review
Biochemistry & Molecular Biology
Mannon Geindreau, Francois Ghiringhelli, Melanie Bruchard
Summary: VEGF plays a crucial role in tumor growth by promoting angiogenesis and modulating the immune response. Clinical approval has been given to therapies targeting VEGF for the treatment of various cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Pedro Pinto-Bravo, Maria Rosa Rebordao, Ana Amaral, Carina Fernandes, Antonio Galvao, Elisabete Silva, Pedro Pessa-Santos, Graca Alexandre-Pires, Rosario P. Roberto da Costa, Dariusz J. Skarzynski, Graca Ferreira-Dias
Summary: The oviduct provides ideal conditions for fertilization and early embryonic development, with proper vascularization being essential for its physiological function. This study examined differences in microvascular density across different portions of the equine oviduct and found that angiogenic factors and their receptors are expressed in all studied regions, in line with microvascular patterns.
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Miki Sato-Akushichi, Shinji Ono, Tatsuro Taneda, Gerd Klose, Asuka Sasamori, Youngseok Song
Summary: This paper evaluates the one-year treatment outcome of full or reduced photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) combination therapy for pachychoroid neovasculopathy (PNV). The results showed that both full and reduced treatment reduced central retinal thickness and central choroidal thickness, and these improvements were maintained for one year after the initial combination therapy. The recurrence rate was similar between full and reduced treatment. One shot of anti-VEGF and full or reduced PDT combination therapy had similar efficacy in treating PNV. More prospective, large-scale, and long-term studies are needed to determine a better treatment for PNV.
Article
Nanoscience & Nanotechnology
Min Jeong Kang, Kug-Hwan Roh, Jae Sang Lee, Jae Hee Lee, SaeGwang Park, Dong Woo Lim
Summary: Genetically engineered fusion polypeptides were designed and synthesized to target vascular endothelial growth factor receptor 1 (VEGFR1) and inhibit angiogenesis. These fusion polypeptides showed potential in vitro by inhibiting VEGFR1-VEGF binding and tube formation of endothelial cells, and in vivo by suppressing laser-induced choroidal neovascularization in a mouse model. This study suggests that VEGFR1-targeting fusion polypeptides have great potential for treating neovascularization diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Pharmacology & Pharmacy
Matteo Fallico, Iacopo Macchi, Andrea Maugeri, Giuliana Favara, Martina Barchitta, Roberta Magnano San Lio, Antonella Agodi, Andrea Russo, Antonio Longo, Teresio Avitabile, Niccolo Castellino, Michele Reibaldi, Francesco Pignatelli, Maria Vadala, Clara Patane, Marcella Nebbioso, Vincenza Bonfiglio
Summary: The study aimed to assess the functional and anatomical outcomes of intravitreal anti-VEGF monotherapy compared to a combination therapy with verteporfin PDT for retinal angiomatous proliferation (RAP). The results showed that the combination therapy group had better improvements in best corrected visual acuity and central macular thickness compared to the anti-VEGF monotherapy group. The importance rating for this study is 8 out of 10.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Yanli Zhu, Jikai Wang, Haitao Xie, Chengxiao Fu, Jiecan Zhou, Hailing Liu, Pengfei Zeng, Yiyang Sun
Summary: This article presents a new aptasensing platform for sensitive and specific detection of malignancy-associated biomarkers. The platform utilizes alkaline-earth sulfide nanodots as fluorescent labels, which can be excited by near-infrared light, to achieve low detection limits and reliable quantification. Additionally, the platform enables visual analysis and detection of target analytes through color transformation.
ANALYTICAL CHEMISTRY
(2022)
Article
Pediatrics
Chiori Kondo, Chiharu Iwahashi, Shoko Utamura, Kazuki Kuniyoshi, Yuhei Konishi, Norihisa Wada, Ryo Kawasaki, Shunji Kusaka
Summary: This study investigated the incidence and clinical characteristics of retinal detachment (RD) after anti-vascular endothelial growth factor (VEGF) therapy for retinopathy of prematurity (ROP). The results showed that approximately 8% of eyes developed RD about 10 weeks after anti-VEGF therapy. Eyes with a history of plus disease should be carefully monitored after anti-VEGF therapy for ROP.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, Research & Experimental
Lei Xi
Summary: Ocular ischemia is a vision-threatening disease associated with various ocular diseases. This study investigated the effects of pigment epithelium derived factor (PEDF) and anti-vascular endothelial growth factor (anti-VEGF) therapy, as well as their combined use, on an ex vivo ischemic rat eye model. The results showed that the combination of PEDF and anti-VEGF significantly reduced the staining intensity of VEGF and GFAP, and decreased the number of TUNEL-positive nuclei, indicating its potential as a therapeutic strategy for ischemic retinal and choroidal diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Endocrinology & Metabolism
Jiasheng Chen, Haowei Wang, Weiqiang Qiu
Summary: This study aimed to compare the efficacy of anti-VEGF therapy alone versus LP therapy alone or anti-VEGF therapy combined with LP therapy for DME through a network meta-analysis. The results showed that anti-VEGF therapy significantly improved BCVA compared to the combined and LP therapies at six months, while there was no difference in reducing CMT between the anti-VEGF and combined therapies at six months. At 12 months, there was no significant difference between the two therapies in terms of BCVA and CMT.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rajya L. Gurung, Liesel M. FitzGerald, Ebony Liu, Bennet J. McComish, Georgia Kaidonis, Bronwyn Ridge, Alex W. Hewitt, Brendan J. Vote, Nitin Verma, Jamie E. Craig, Kathryn P. Burdon
Summary: This study identified genetic determinants associated with anti-VEGF treatment response in patients with DME through a genome-wide association study. Multiple genetic loci were found to predict treatment outcomes, potentially leading to personalized treatment approaches for managing DME.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)