Article
Otorhinolaryngology
Wataru Okano, Ryuichi Hayashi, Kazuto Matsuura, Takeshi Shinozaki, Toshifumi Tomioka
Summary: The study indicates that targeted neck dissection (ND) after definitive chemoradiotherapy is an effective intervention for patients with cervical disease recurrence, showing promising survival rates and control rates.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Medicine, General & Internal
Austin J. Iovoli, Lauren Turecki, Michelle L. Qiu, Michael Khan, Kelsey Smith, Han Yu, Sung Jun Ma, Mark K. Farrugia, Anurag K. Singh
Summary: Oral mucositis is a common adverse effect in head and neck cancer patients receiving radiation therapy. This study aimed to investigate the associations between the severity of oral mucositis and clinical outcomes and quality of life. The results showed that severe oral mucositis was associated with feeding tube placement, hospitalization, opiate use, and weight loss.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Nutrition & Dietetics
Zalina Abu Zaid, May Kay Neoh, Zulfitri Azuan Mat Daud, Nor Baizura Md Yusop, Zuriati Ibrahim, Zuwariah Abdul Rahman, Norshariza Jamhuri, Aishah Zafirah Abdul Azim
Summary: This study aimed to evaluate the weight loss during and post-treatment among head and neck cancer patients. The study found that the average weight loss during treatment was 7.4%, and post-treatment weight loss was 2.1%. One month after treatment completion, patients showed significant improvements in nutrition status and muscle mass, but there was a decrease in oral nutritional supplement intake.
Review
Oncology
Linda Chen, Nadeem Riaz, Nancy Lee, Sean McBride
Summary: Management of HPV-related head and neck cancer requires a multidisciplinary approach to balance treatment outcomes and toxicity. Considerations include radiation dose, target delineation, chemoradiation, postoperative radiotherapy, and definitive radiotherapy.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Glenn J. Hanna, Anne O'Neill, Kee-Young Shin, Kristine Wong, Vickie Y. Jo, Charles T. Quinn, Jennifer M. Cutler, Michelle Flynn, Patrick H. Lizotte, Donald J. Annino, Laura A. Goguen, Jason Kass, Eleni M. Rettig, Rosh K. Sethi, Jochen H. Lorch, Jonathan D. Schoenfeld, Danielle N. Margalit, Roy B. Tishler, Peter C. Everett, Anupam M. Desai, Megan E. Cavanaugh, Cloud P. Paweletz, Ann Marie Egloff, Ravindra Uppaluri, Robert Haddad
Summary: This study investigated the use of dual immune-checkpoint inhibition in locoregionally recurrent squamous cell carcinoma of the head and neck (SCCHN) before and after surgery. The results showed a promising response rate and suggests further evaluation of this strategy.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Michi Sawabe, Daisuke Kawakita, Isao Oze, Shinichi Iwasaki, Yasuhisa Hasegawa, Shingo Murakami, Hidemi Ito, Nobuhiro Hanai, Keitaro Matsuo
Summary: This study is the first to suggest an association between prediagnostic folate intake and head and neck squamous cell carcinoma (HNSCC) survival that differs based on fluorouracil (FU)-containing chemotherapy. In the FU-containing chemotherapy group, higher folate intake is associated with better overall survival, while no clear association is observed in the non-FU-containing chemotherapy group. This finding indicates that the folate status affects the heterogeneity of one-carbon metabolism in HNSCC.
Article
Medicine, General & Internal
Michael H. Zhang, David Cao, Daniel T. Ginat
Summary: The study developed a radiomic model combined with clinical parameters to successfully predict nodal response to induction chemotherapy for locally advanced head and neck squamous cell carcinoma patients, showing promising clinical implications.
Article
Oncology
Vijay Maruti Patil, Vanita Noronha, Nandini Menon, Ajay Singh, Sarbani Ghosh-Laskar, Ashwini Budrukkar, Atanu Bhattacharjee, Monali Swain, Vijayalakshmi Mathrudev, Kavita Nawale, Arun Balaji, Zoya Peelay, Mitali Alone, Shruti Pathak, Abhishek Mahajan, Suman Kumar, Nilendu Purandare, Archi Agarwal, Ameya Puranik, Shantanu Pendse, Monica Reddy Yallala, Harsh Sahu, Venkatesh Kapu, Sayak Dey, Jatin Choudhary, Madala Ravi Krishna, Alok Shetty, Naveen Karuvandan, Rahul Ravind, Rahul Rai, Kunal Jobanputra, Pankaj Chaturvedi, Prathamesh S. Pai, Devendra Chaukar, Sudhir Nair, Shivakumar Thiagarajan, Kumar Prabhash
Summary: This study investigated the efficacy of docetaxel as a radiosensitizer in cisplatin-ineligible patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC) undergoing chemoradiation. The results showed that the addition of docetaxel to radiation improved 2-year disease-free survival (DFS) and overall survival (OS) compared to radiation alone.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Brian J. Park, Austin K. Mattox, Daniel Clayburgh, Mihir Patel, R. Bryan Bell, Bevan Yueh, Rom Leidner, Hong Xiao, Marcus Couey, Shiting Li, Tingting Qin, Maureen A. Sartor, Belinda Cairns, Tracy MacDonough, Kyle Halliwill, Daniel Deschler, Derrick T. Lin, William C. Faquin, Peter M. Sadow, Sara Pai
Summary: PD-L1 testing is important for decision-making in HNSCC treatment. Chemoradiation therapy has a significant impact on PD-L1 expression, especially when using a cut-off of CPS >= 20 and >= 50. Oral cavity cancer shows higher discordance rates in local and regional recurrence, suggesting the need for repeat biopsy.
Article
Oncology
M. Vreugdenhil, Charles Fong, Paul Sanghera, Andrew Hartley, Janet Dunn, Hisham Mehanna
Summary: Interest in hypofractionated accelerated chemoradiation for head and neck cancer has increased during the COVID-19 pandemic, with a lack of prospective data from randomised trials. A study comparing different fractionation schedules showed no significant differences in local control, overall survival, or quality of life measures at a minimum follow-up of two years post-treatment. Despite limitations, the data supports the use of hypofractionated accelerated chemoradiation to avoid treatment delays during pandemics.
Article
Medicine, General & Internal
Sung Jun Ma, Michael Khan, Udit Chatterjee, Sharon Santhosh, Mahnoor Hashmi, Jasmin Gill, Brian Yu, Austin Iovoli, Mark Farrugia, Kimberly Wooten, Vishal Gupta, Ryan McSpadden, Han Yu, Moni A. Kuriakose, Michael R. Markiewicz, Ayham Al-Afif, Wesley L. Hicks, Mukund Seshadri, Andrew D. Ray, Elizabeth Repasky, Anurag K. Singh
Summary: This retrospective, observational, single-institution cohort study found that overweight BMI is associated with better treatment response, survival outcomes, and lower locoregional failure in patients with head and neck cancer undergoing chemoradiotherapy. This finding contributes to our understanding of the role of BMI in patients with head and neck cancer.
Article
Multidisciplinary Sciences
Nedeljko Jovanovic, Tricia Chinnery, Sarah A. Mattonen, David A. Palma, Philip C. Doyle, Julie A. Theurer
Summary: This scoping review identified the definitions and methods used to objectively assess sarcopenia in head and neck cancer patients. The majority of studies used computed tomography (CT) and skeletal muscle index (SMI) to evaluate sarcopenia. Measurement of skeletal muscle mass (SMM) at the third cervical vertebra (C3) may serve as a practical biomarker for detecting sarcopenia in this population.
Article
Oncology
Aprajita Mall, Preety Negi, Ashwin Oommen Philip, Pamela A. Kingsley
Summary: This study evaluated the response to induction chemotherapy in inoperable locally advanced head and neck cancer patients. The results showed a complete response rate of 57.7% with induction chemotherapy, with younger patients having a better response. However, a higher grade of radiation-induced mucositis was observed in patients receiving three cycles of induction chemotherapy (ICT) and aged over 50 years.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Review
Oncology
Hoda Mahdavi
Summary: Locally advanced stages of squamous cancers of the head and neck (LAHNCs) have a high risk of local and systemic relapse. The addition of induction therapy to the standard concurrent chemoradiotherapy (CCRT) has been widely used but did not improve survival rates in unselected populations. The TPF induction regimen showed superiority but did not demonstrate a survival advantage over CCRT alone. Newer systemic therapy combinations are currently being tested to find more effective treatments for LAHNCs.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
