Article
Cell Biology
Minghui Jiang, Jiahui Liu, Wenli Liu, Xiaoliang Zhu, Yasmeen Bano, Hongbing Liao, Haiyan Li, Hai-Hong Jiang
Summary: The study showed that BMSC secretome can activate AVW fibroblasts, aiding in the acceleration of recovery from simulated birth trauma-induced SUI in rats.
Review
Cell & Tissue Engineering
Gianna Mariotti, Stefano Salciccia, Pietro Viscuso, Giulio Bevilacqua, Paolo Casale, Marco Frisenda, Giovanni Battista Di Pierro, Susanna Cattarino, Alessandro Gentilucci, Davide Rosati, Beatrice Sciarra, Alessandro Sciarra
Summary: This systematic review and meta-analysis examined clinical trials on the use of autologous stem cell injection for the treatment of stress urinary incontinence in humans. The results showed that autologous muscle-derived stem cells and adipocyte-derived stem cells injection is safe and has a mean rate of continence recovery of 41%. It is suggested that better clinical trials should be designed to objectively evaluate the modifications inside the urethral sphincter or long-term functional results.
CURRENT STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yu-Hee Kim, Hyun-Ji Lee, Kyung-Ah Cho, So-Youn Woo, Kyung-Ha Ryu
Summary: This study found that conditioned medium obtained from human tonsil-derived MSCs (T-MSC CM) can inhibit adipocyte differentiation by regulating glucocorticoid signal transduction, thereby reducing obesity. The experiments showed that T-MSC CM can attenuate early-stage adipocyte differentiation and protect mice from the negative effects induced by glucocorticoid treatment. Additionally, T-MSC CM enhances megakaryocyte differentiation and protects blood platelet counts.
Article
Biochemistry & Molecular Biology
Florian A. Schmid, J. Koudy Williams, Thomas M. Kessler, Arnulf Stenzl, Wilhelm K. Aicher, Karl-Erik Andersson, Daniel Eberli
Summary: Urinary incontinence is a major global health issue affecting over 400 million people worldwide. Stress urinary incontinence is the most prevalent subtype, primarily caused by pregnancy, childbirth, and pelvic trauma. Current treatments include physiotherapy, behavioral changes, and surgery, but alternative, minimally invasive options are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Minsung Kim, Bo-Young Oh, Ji-Seon Lee, Dogeon Yoon, You-Rin Kim, Wook Chun, Jong Wan Kim, Il Tae Son
Summary: This study demonstrated for the first time that implanted adipose-derived stem cells can restore impaired smooth muscle cells at the injury site, showing stem cell fate corresponding to the established IAS-specific AI model.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ejaz R. Dar, Mudasir B. Gugjoo, Moien Javaid, Shahid Hussain, Mujeeb R. Fazili, Kuldeep Dhama, Taha Alqahtani, Ali M. Alqahtani, Riaz A. Shah, Talha Bin Emran
Summary: The study evaluates the influence of ambient temperature, donor physiological status, and tissue source on sheep mesenchymal stem cells. Results show that adipose tissue-derived MSCs from full term pregnant female sheep exhibit higher potential for proliferation and differentiation compared to male sheep-derived MSCs. Cryopreserved MSCs have similar characteristics to fresh cells. Therefore, it is important to consider tissue type and donor physiological status when applying MSCs in clinical settings.
Article
Orthopedics
Andrea Pintore, Donato Notarfrancesco, Arnaldo Zara, Antonio Oliviero, Filippo Migliorini, Francesco Oliva, Nicola Maffulli
Summary: The study found that autologous mesenchymal stem cell (MSC) injections can improve clinical and functional outcomes in knee osteoarthritis (KOA) patients, with similar results between autologous bone marrow cells (BMAC) and adipose-derived stromal cells (ADSCs). Measurements of Knee Injury and Osteoarthritis Outcome Score (KOOS), Oxford Knee Score (OKS), and visual analog scale (VAS) were collected from 102 patients with KOA before the procedures, at one month, and at six months post-injection.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zahra Eydian, Alaleh Mohammad Ghasemi, Samira Ansari, Ali Naghi Kamali, Maryam Khosravi, Sima Momtaz, Sanaz Riki, Laleh Rafighdoost, Reza Entezari Heravi
Summary: This study demonstrates the differentiation of mesenchymal stem cells (MSCs) from human adipose tissue and bone marrow into functional beta-islet cells. It suggests that adipose stem cells may be a better choice for the treatment of diabetes mellitus due to their higher potency.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Endocrinology & Metabolism
Lu Wang, Yali Wang, Yuancui Xiang, Jinping Ma, Hui Zhang, Jingfang Dai, Yanan Hou, Yupei Yang, Jingru Ma, Hongjuan Li
Summary: This study investigated the effects of ADSCs-extracellular vesicles carrying miR-93 in stress urinary incontinence, showcasing their regulatory role in collagen metabolism. The delivered miR-93 targeted F3 expression to promote extracellular matrix remodeling in fibroblasts and activation of satellite cells in stress urinary incontinence. Extracellular vesicles from ADSCs played a crucial role in delivering miR-93 and regulating gene expression in target cells to alleviate symptoms of stress urinary incontinence.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Guobing Zhuang, Yan Wen, Mason Briggs, Qingchun Shao, Darlene Tran, Hongbo Wang, Bertha Chen
Summary: The study demonstrates the paracrine effects of human smooth muscle cell progenitors derived from pluripotent stem cells on stress urinary incontinence rodents. The conditioned media from these cells improved urethral leak point pressure and collagen and elastin content in the SUI rat, suggesting a potential therapeutic approach for SUI and related pelvic floor disorders.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Orthopedics
Christina Holmes, Wataru Ishida, Alexander Perdomo-Pantoja, Benjamin D. Elder, Ethan Cottrill, John Locke, Timothy F. Witham
Summary: The study compared the efficacy of ASCs and BMCs for successful fusion in a rat lumbar fusion model. Results showed that rASCs yielded the largest fusion masses, although statistically comparable to rBMCs. The in vitro osteogenic differentiation capacities of P2 rASCs and rBMCs were similar.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Cell & Tissue Engineering
Meng Liu, Ying Wang, Guo Gao, Wei-Xin Zhao, Qiang Fu
Summary: Stress urinary incontinence (SUI) is a common urinary system disease worldwide. Medical therapy and surgery can control symptoms, but may cause complications. Recent research explores the potential of using stem cells to treat SUI.
CURRENT STEM CELL RESEARCH & THERAPY
(2023)