Review
Cell Biology
Seung Joo Chon, Zobia Umair, Mee-Sup Yoon
Summary: Premature ovarian insufficiency (POI) is a condition characterized by the loss of normal ovarian function before the age of 40, affecting a small percentage of women under 40. The condition is biochemically defined by amenorrhea, low estrogen levels, and high gonadotropin levels, potentially leading to infertility. POI has a heterogeneous etiology, including both genetic and non-genetic factors, and current research focuses on genetic basis, non-coding RNA, and animal models to uncover pathogenesis and potential treatment targets. Despite recent advances, understanding gene regulatory networks and exploring therapies remain critical for future research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xue Jiao, Tingting Meng, Yiwei Zhai, Lijuan Zhao, Wei Luo, Peihao Liu, Yingying Qin
Summary: Ovarian reserve indicators deteriorate with the progression of ovarian insufficiency, with an increase in FSH and LH but a decrease in AMH, inhibin B, AFC, E-2 and T. AMH has the highest predictive value for POI, and the combination of AMH and AFC is promising for early prediction. Significant differences exist in hormone status among women with different etiologies of POI, with genetic POI showing the worst hormone status.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Linlin Liu, Huasong Wang, Guo Liang Xu, Lin Liu
Summary: Tet enzymes, specifically Tet1, are crucial for DNA demethylation and have a significant impact on stem cell differentiation and pluripotency. The deficiency of Tet1 can lead to accelerated reproductive failure due to decreased follicle reserve and other molecular changes in oocytes, indicating a potential link to premature ovarian failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xinning Li, Xuelan Li, Ling Deng
Summary: Chrysin regulates hormone expression and weight, inhibits inflammation and oxidative stress, improves ovarian function in animals with POF, and inhibits apoptosis of ovarian granulosa cells. Furthermore, Chrysin targets ER beta and activates its expression. This suggests that Chrysin has potential for the treatment of POF.
Article
Biotechnology & Applied Microbiology
Jiying Chen, Qinger Zhou, Yonggang Zhang, Wenqing Tan, Hanchao Gao, Liying Zhou, Shuixiu Xiao, Jinhua Gao, Jing Li, Zhiying Zhu
Summary: Using serum-based metabolomics, we identified differentially expressed metabolites (DEMs) in patients with PCOS and POF, as well as in healthy individuals. These DEMs showed significant dysregulation in intergroup comparisons and some DEMs exhibited potential clinical significance in patients with PCOS and POF.
Article
Biochemistry & Molecular Biology
Xiaoke Tang, Hongjuan Li, Yali Wang, Li Zeng, Ling Long, Yajun Qu, Hui Yang, Xiaolin Zhang, Yanmin Li, Yanni Yu, Qi Zhou, Man Luo
Summary: This study found that chronic fluoride exposure had adverse effects on female reproductive health in rats, including fluoride accumulation, decreased ovarian function, disrupted estrous cycles, and induction of apoptosis in ovarian cells. The findings suggest that chronic fluoride exposure may contribute to ovarian dysfunction and premature ovarian failure.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jingyi Wen, Yanzhi Feng, Wei Yan, Suzhen Yuan, Jinjin Zhang, Aiyue Luo, Shixuan Wang
Summary: This study reveals the characteristics of vaginal microbiota in POI patients and their relationship with reduced ovarian reserve, endocrine disruption, and symptoms of perimenopausal syndrome. Differences in vaginal microbiota between POI and POF patients are also identified.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Zhongkang Li, Mingle Zhang, Jiahua Zheng, Yanpeng Tian, Huihui Zhang, Yi Tan, Qian Li, Jingkun Zhang, Xianghua Huang
Summary: This study demonstrated that transplantation of hUCMSC-Exos can effectively promote ovarian recovery in POI, with the proliferation of ovarian cells being regulated by the Hippo pathway.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
C. Sonigo, A. Mayeur, M. Sadoun, M. Pinto, J. Benguigui, N. Frydman, S. Monnot, A. Benachi, J. Steffann, M. Grynberg
Summary: In females with FMR1 mutations or premutations undergoing preimplantation genetic testing (PGT), having seven or more mature oocytes in a cycle leads to an 83% chance of obtaining one or more healthy embryos. This study suggests that the number of mature oocytes is crucial in determining the success of transferring a healthy embryo in PGT cycles for FMR1 carriers.
HUMAN REPRODUCTION
(2021)
Review
Cell Biology
Qiaojuan Mei, Hongbei Mou, Xuemei Liu, Wenpei Xiang
Summary: Human umbilical cord mesenchymal stem cells have been reported to improve ovarian function through paracrine effects, but their clinical application is still relatively rare. This paper reviews their role in treating reproductive aging and provides a theoretical basis for further research and clinical treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Maki Fukami
Summary: Ovarian dysfunction is a common feature in women with Turner syndrome, in which oocyte apoptosis is accelerated and leads to streak gonads formation. The accelerated germ cell loss in 45,X ovaries may be caused by chromosomal pairing failure, impaired coupling between oocytes and granulosa cells, and reduced dosage of certain genes on the X chromosome. Further research on the mechanisms of ovarian dysfunction is necessary to improve reproductive outcomes in women with Turner syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Xuefeng Bai, Shaowei Wang
Summary: Premature ovarian failure (POF) is a multifactorial disease characterized by secondary amenorrhea, decreased estrogen levels, and increased gonadotropin levels in women under 40. The prevalence of POF is increasing and it has adverse effects on both the physiology and psychology of women. Hormone replacement therapy is the recommended treatment, and a multidisciplinary approach is needed to improve patients' quality of life. Recent studies suggest that the depletion of ovarian reserve function due to increased primordial follicular activation or insufficiency is the primary mechanism of POF. Therefore, understanding the processes and pathways involved in primordial follicle activation and exploring effective interventions are crucial for POF treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Mengwen Zhang, Xiaowei Yu, Danjie Li, Ning Ma, Zhentong Wei, Xinxin Ci, Songling Zhang
Summary: This study investigated the protective function of Daphnetin against ovarian aging induced by D-galactose in mice and found that Daphnetin can protect against premature ovarian failure by increasing Nrf2 expression and inhibiting NLRP3 activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Narjes Nouri, Olduz Shareghi-Oskoue, Leili Aghebati-Maleki, Shahla Danaii, Javad Ahmadian Heris, Mohammad Sadegh Soltani-Zangbar, Amin Kamrani, Mehdi Yousefi
Summary: Premature ovarian failure is a complex problem with diverse causes and clinical manifestations. Lack of ovarian sex hormones is believed to be a major factor in its occurrence. Despite limited scientific research progress, clinical medicine has made significant strides in optimizing the quality of life and long-term health of women with premature ovarian insufficiency through timely intervention. Recent investigations have focused on the regulating effects of small RNA molecules on various ovarian processes. This literature review discusses the mechanisms of miRNAs in regulating gene expression in the ovary after transcription.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Nicolas Vallet, Nicolas Boissel, Elisabeth Elefant, Florian Chevillon, Helene Pasquer, Charlotte Calvo, Nathalie Dhedin, Catherine Poirot
Summary: Traditional anticancer treatments may lead to premature ovarian failure (POF), but new targeted therapies may have favorable effects on the primordial follicle pool, potentially delaying POF onset. Research on targeted therapies suggests they could help maintain the PF pool, but further studies are needed to confirm these findings.