Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 22, Issue 4, Pages 624-630Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2012.02.004
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Funding
- National Institute of Neurological Disorders and Stroke [R01NS073055]
- National Science Foundation [1120796]
- Joseph A & Esther Klingenstein Fund (Neuroscience Award)
- March of Dimes (Basil O'Connor Award)
- Shriners Hospital for Children [08-NCA-013]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1120796] Funding Source: National Science Foundation
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Spinal cord development is a complex process involving generation of the appropriate number of cells, acquisition of distinctive phenotypes and establishment of functional connections that enable execution of critical functions such as sensation and locomotion. Here we review the basic cellular events occurring during spinal cord development, highlighting studies that demonstrate the roles of electrical activity in this process. We conclude that the participation of different forms of electrical activity is evident from the beginning of spinal cord development and intermingles with other developmental cues and programs to implement dynamic and integrated control of spinal cord function.
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