Review
Chemistry, Medicinal
Jean-Pierre Girolami, Nadine Bouby, Christine Richer-Giudicelli, Francois Alhenc-Gelas
Summary: This review focuses on the physiological role of the kallikrein-kinin system in arteries, heart, and kidney, and the implications of kallikrein and kinin actions in diseases like ischemic and diabetic conditions affecting these organs. It discusses pharmacological and genetic studies targeting kallikrein, ACE/kininase II, and the kinin receptors B1 (B1R) and B2 (B2R), with an emphasis on potential therapeutic interest and limitations in manipulating B1R or B2R activity in cardiovascular and renal diseases, based on recent clinical and experimental studies.
Article
Multidisciplinary Sciences
Nicholas P. Giangreco, Guillaume Lebreton, Susan Restaino, Maryjane Farr, Emmanuel Zorn, Paolo C. Colombo, Jignesh Patel, Rajesh Kumar Soni, Pascal Leprince, Jon Kobashigawa, Nicholas P. Tatonetti, Barry M. Fine
Summary: This study utilized proteomics to identify potential biomarkers for predicting post-transplant survival in heart failure patients. The analysis identified six protein markers that have a predictive performance above AUROC of 0.6, including Prothrombin, anti-plasmin, Factor IX, carboxypeptidase 2, HGF activator, and low molecular weight kininogen. Additionally, the analysis revealed that upregulation of components of the kallikrein-kinin system and downregulation of kininogen prior to transplant were associated with improved survival after transplant.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Mahmoud E. Youssef, Mustafa A. Abdel-Reheim, Mohamed A. Morsy, Mahmoud El-Daly, Gamal M. K. Atwa, Galal Yahya, Simona Cavalu, Sameh Saber, Ahmed Gaafar Ahmed Gaafar
Summary: This study examined the effectiveness of the antithrombotic agent dabigatran in treating arthritis in rats. The results showed that dabigatran had anti-inflammatory and antioxidant effects, making it a potential novel therapeutic strategy for arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Jill W. Verlander, Hyun-Wook Lee, Susan M. Wall, Autumn N. Harris, I. David Weiner
Summary: This study investigates the role of the proximal tubule in regulating the renal response to acid-base disturbances. The findings show that the proximal tubule controls the phenotypic and remodeling responses of the collecting duct to acidosis. Deletion of specific proteins in the proximal tubule leads to spontaneous metabolic acidosis and impairs the collecting duct's ability to respond to acid loading.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhiye Zhang, Chuanbin Shen, Mingqian Fang, Yajun Han, Chengbo Long, Weihui Liu, Min Yang, Ming Liu, Dengdeng Zhang, Qiqi Cao, Xue Chen, Yaqun Fang, Qiumin Lu, Zongliu Hou, Yaxiong Li, Zhenze Liu, Xi Lei, Heyu Ni, Ren Lai
Summary: Ischemic stroke is a major cause of death and disability worldwide. This study identifies a promising inhibitor called sylvestin which can protect against ischemic stroke without increasing the risk of bleeding.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemical Research Methods
Tanja Gangnus, Bjoern B. Burckhardt
Summary: The kallikrein-kinin system is involved in physiological and pathophysiological processes, but understanding of its in vivo role is limited. A sensitive LC-MS/MS platform has been developed to accurately determine kinin levels, successfully detecting low pg/mL levels in the plasma of healthy volunteers.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Allergy
Edward J. Duckworth, Nivetha Murugesan, Lily Li, Louise J. Rushbrooke, Daniel K. Lee, Gian Marco De Donatis, Andreas Maetzel, Christopher M. Yea, Sally L. Hampton, Edward P. Feener
Summary: This report describes the pharmacological and pharmacodynamic properties of the novel oral small-molecule PKa inhibitor KVD900 for the potential on-demand treatment of HAE. The results show that orally administered KVD900 rapidly inhibits PKa activity, kallikrein kinin system activation, and HK cleavage in plasma, providing an opportunity to halt the generation of bradykinin and reverse HAE attacks.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Engineering, Environmental
Yuzhu Zhang, Yao Pei, Qian S. Liu, Yurou Gao, Ke Min, Zigu Chen, Zhao Shu, Qian Liu, Qunfang Zhou, Guibin Jiang
Summary: Atmospheric particulate matter (PM) disrupts hematological homeostasis by targeting the plasma kallikreinkinin system (KKS) and activating a cascade of zymogen. The specific components responsible for PM-induced hematological effects remain unknown. This study investigated the effects of different standard reference materials (SRMs) of PM on plasma KKS activation and found that the soot content in atmospheric PM from different sources contributes to distinct effects on KKS activation. This finding is crucial for assessing the health risks of inhaled fine PM, considering its contact with the human circulatory system.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Cell Biology
Anastasia Sudarikova, Mikhail Fomin, Regina F. Sultanova, Ying Zhao, Samantha Perez, Mark Domondon, Margarita Shamatova, Daria Lysikova, Denisha R. Spires, Daria Ilatovskaya
Summary: This study investigates the role of histamine-related pathways in the kidney, specifically in the collecting duct cells. The findings demonstrate the expression of histamine receptors and enzymes responsible for histamine metabolism and synthesis in these cells, as well as the effects of histamine on intracellular calcium and cAMP levels. Additionally, histamine inhibits the activity of epithelial sodium channels and decreases the expression of alpha ENaC. These results suggest potential implications of histamine in inflammation-related renal conditions.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Ana Carolina Oliveira, Amanda Roberta Revoredo Vicentino, Daniele Andrade, Isabela Resende Pereira, Leonardo Saboia-Vahia, Otacilio da Cruz Moreira, Carla Eponina Carvalho-Pinto, Julia Barbalho da Mota, Leonardo Maciel, Glaucia Vilar-Pereira, Joao B. Pesquero, Joseli Lannes-Vieira, Pierre Sirois, Antonio Carlos Campos de Carvalho, Julio Scharfstein
Summary: We investigated the role of B1R receptor in the development of Chagas disease caused by Trypanosoma cruzi. Our findings suggest that blocking the B1R receptor can reduce heart parasitism and cardiac injury in acute and chronic Chagas disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Miklos Lipcsey, Barbro Persson, Oskar Eriksson, Anna M. Blom, Karin Fromell, Michael Hultstrom, Markus Huber-Lang, Kristina N. Ekdahl, Robert Frithiof, Bo Nilsson
Summary: Severe COVID-19 can lead to ARDS-like lung injury associated with vascular inflammation, thrombosis, and angiogenesis, in which the intravascular innate immune system (IIIS) plays a crucial role. Activation of blood cascade systems in critically ill COVID-19 patients is linked to organ damage, illness severity scores, and survival, suggesting potential prognostic markers and therapeutic targets for the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Luana Sella Motta Maia, Bettina Burger, Arije Ghannam, Fernanda Leonel Nunes, Mariana Paes Leme Ferriani, Marina Mendonca Dias, Luisa Karla Arruda, Christian Drouet, Sven Cichon
Summary: This study presents a recessive form of hereditary angioedema caused by a missense variant in the SERPING1 gene. The variant strongly affects the function of C1-inhibitor (C1-INH), particularly in inhibiting C1s and kallikrein. These findings reinforce the notion that C1-INH deficiency is a conformational disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Eric R. Barros Lamus, Valentina Carotti, Christine R. S. de Vries, Femke Witsel, Onno J. Arntz, Fons A. J. van de Loo, Cristian A. Carvajal, Rene J. M. Bindels, Joost G. J. Hoenderop, Juan P. Rigalli
Summary: This study investigates the regulatory effect of EVs from renal proximal tubule and collecting duct cells on extracellular ATP levels and the expression of the alpha subunit of the epithelial sodium channel. The findings reveal that EVs can modulate purinergic signaling through mechanisms such as miRNA regulation and ATPase activity, impacting renal physiological and pathophysiological processes. Further research on EV release and cargo content may shed light on the role of EVs in renal purinergic signaling.
Article
Multidisciplinary Sciences
Xiaoyuan Qian, Junlai Wan, Yuanzhong Tan, Zhenrui Liu, Ying Zhang
Summary: This study investigated the prognostic factors and the impact of cytoreductive nephrectomy (CNx) on the outcomes in patients with metastatic renal collecting duct carcinoma (CDC). It found that CNx improved the prognosis of metastatic CDC patients, and surgical resection of visible lesions and suitable chemotherapy were identified as alternative treatment strategies.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hamit Hakan Armagan, Mustafa Naziroglu
Summary: The study found that maintaining GSH homeostasis is crucial for quenching oxidative stress in cortical collecting duct cells and is equally important for modulating TRPM2 activation. Suppressing apoptosis and mitochondrial oxidative stress responses elicited by the oxidant action of GSH depletion is essential.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Urology & Nephrology
Mykola Mamenko, Isha Dhande, Viktor Tomilin, Oleg Zaika, Nabila Boukelmoune, Yaming Zhu, Manuel L. Gonzalez-Garay, Oleh Pochynyuk, Peter A. Doris
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2016)
Review
Immunology
Viktor Tomilin, Mykola Mamenko, Oleg Zaika, Oleh Pochynyuk
SEMINARS IN IMMUNOPATHOLOGY
(2016)
Article
Cell Biology
Xia Hu, Morayo G. Adebiyi, Jialie Luo, Kaiqi Sun, Thanh-Thuy T. Le, Yujin Zhang, Hongyu Wu, Shushan Zhao, Harry Karmouty-Quintana, Hong Liu, Aji Huang, Yuan Edward Wen, Oleg L. Zaika, Mykola Mamenko, Oleh M. Pochynyuk, Rodney E. Kellems, Holger K. Eltzschig, Michael R. Blackburn, Edgar T. Walters, Dong Huang, Hongzhen Hu, Yang Xia
Article
Urology & Nephrology
Mykola V. Mamenko, Nabila Boukelmoune, Viktor N. Tomilin, Oleg L. Zaika, V. Behrana Jensen, Roger G. O'Neil, Oleh M. Pochynyuk
KIDNEY INTERNATIONAL
(2017)
Article
Cell Biology
Mykola Mamenko, Oleg Zaika, Viktor Tomilin, V. Behrana Jensen, Oleh Pochynyuk
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Alena Cherezova, Viktor Tomilin, Vadym Buncha, Oleg Zaika, Pablo A. Ortiz, Fang Mei, Xiaodong Cheng, Mykola Mamenko, Oleh Pochynyuk
Article
Pharmacology & Pharmacy
Camilla F. Wenceslau, Cameron G. McCarthy, Theodora Szasz, Fabiano B. Calmasini, Mykola Mamenko, R. Clinton Webb
PHARMACOLOGICAL RESEARCH
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Viktor N. Tomilin, Oleg Zaika, Mykola Mamenko, Oleh M. Pochynyuk
Meeting Abstract
Biochemistry & Molecular Biology
Alena Cherezova, Viktor Tomilin, Vadym Buncha, Oleg Zaika, Fang Mei, Xiaodong Cheng, Mykola Mamenko, Oleh Pochynyuk
Meeting Abstract
Biochemistry & Molecular Biology
Isha S. Dhande, Sterling C. Kneedler, Yaming Zhu, Mykola Mamenko, M. John Hicks, Oleh Pochynyuk, Scott E. Wenderfer, Michael C. Braun, Peter A. Doris
Article
Physiology
Minolfa C. Prieto, Virginia Reverte, Mykola Mamenko, Marta Kuczeriszka, Luciana C. Veiras, Carla B. Rosales, Matthew McLellan, Oliver Gentile, V. Behrana Jensen, Atsuhiro Ichihara, Alicia A. McDonough, Oleh M. Pochynyuk, Alexis A. Gonzalez
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Viktor N. Tomilin, Oleh Zaika, Mykola Mamenko, Gail Reif, Darren Wallace, Oleh Pochynyuk
Meeting Abstract
Biochemistry & Molecular Biology
Oleg Zaika, Viktor Tomilin, Mykola Mamenko, Oleh Pochynyuk
Meeting Abstract
Biochemistry & Molecular Biology
Mykola Mamenko, Isha Dhande, Viktor Tomilin, Oleg Zaika, Peter A. Doris
Article
Physiology
Oleg Zaika, Oleg Palygin, Viktor Tomilin, Mykola Mamenko, Alexander Staruschenko, Oleh Pochynyuk
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2016)