Article
Health Care Sciences & Services
Armando Silva-Almodovar, Edward Hackim, Hailey Wolk, Milap C. Nahata
Summary: The study found that over one-third of Medicare patients eligible for Medication Therapy Management with chronic kidney disease had at least one potentially inappropriately prescribed medication. Factors associated with PIPM included worsening renal function, length of MTM eligibility, female gender, and polypharmacy. The majority of PIPMs were prescribed by primary care providers.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Review
Health Care Sciences & Services
Farida Rendrayani, Sofa Dewi Alfian, Wawan Wahyudin, Irma Melyani Puspitasari
Summary: Understanding pharmacists' knowledge, attitudes, and practices (KAP) towards medication therapy management (MTM) is essential for designing successful service delivery. This review examined the KAP of pharmacists globally, as well as their perceived challenges, barriers, and facilitators to MTM provision. The findings showed that pharmacists had considerable knowledge, positive attitudes, and had been practicing some MTM elements. Factors such as age, education, experience, and practice setting were associated with pharmacists' KAP. Challenges related to pharmacist-patient and pharmacist-physician relationships, while barriers included insufficient time, staff, compensation, and training. Patient willingness to participate and educational background were identified as facilitators. These findings can inform the development of MTM programs and interventions to improve effectiveness.
Article
Public, Environmental & Occupational Health
Farida Rendrayani, Sofa Dewi Alfian, Wawan Wahyudin, Irma Melyani Puspitasari
Summary: This study aimed to assess the KAP level of MTM among pharmacists at CHCs in Indonesia and investigate the barriers and facilitators of MTM provision in the future. Results showed that most pharmacists had high knowledge level, but only half had positive attitudes and practices toward MTM. Factors such as gender, practice settings, years of practice, and experience in MTM services were associated with the KAP level. Pharmacists perceived barriers like lack of interprofessional collaboration and patient compliance, and facilitators like chronic disease conditions and current practices.
FRONTIERS IN PUBLIC HEALTH
(2023)
Editorial Material
Biochemistry & Molecular Biology
Francisco Herrera-Gomez, F. Javier Alvarez
Summary: The current healthcare concept promotes personalized treatment through biomarkers for chronic kidney disease patients. Prognostic markers based on real-world evidence aim to identify high-risk patients for better decision-making.
Article
Pharmacology & Pharmacy
Vivien Berger, Christian Sommer, Peggy Boje, Josef Hollmann, Julia Hummelt, Christina Koenig, Susanne Lezius, Annika van der Linde, Corinna Marhenke, Simone Melzer, Nina Michalowski, Michael Baehr, Claudia Langebrake
Summary: This study shows that a structured Closed Loop Medication Management process (CLMM) enables clinical pharmacists to detect and solve medication errors at an early stage, thus improving medication safety. The CLMM provides a suitable framework for medication management of inpatients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Daniel Bundo, Oriol Cunillera, Ariadna Arbiol-Roca, Silvia Cobo-Guerrero, Jose Romano, Neus Gil-Terron, Xavier Fulladosa, Jordi Comas, Ines Rama, Josep M. Cruzado, Betlem Salvador-Gonzalez
Summary: This retrospective cohort study aimed to explore the risk factors associated with reaching the final stage of chronic kidney disease (CKD-G5) while receiving conservative kidney management (CKM). The study found that low eGFR and albuminuria were the primary risk factors. Male gender and uncontrolled blood pressure had a greater impact on the need for kidney replacement therapy (KRT) compared to CKD-G5 with CKM. Increasing age and rurality reduced the probability of KRT but increased the probability of CKD-G5 with CKM. Higher incomes decreased the likelihood of developing CKD-G5 with and without KRT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Joao Victor Salgado, Miguel Angelo Goes, Natalino Salgado Filho
Summary: The global nephrology community acknowledges the increasing burden of kidney disease and emphasizes on early diagnosis, understanding of disease progression, and development of new therapeutic interventions. FGF21 is considered a key regulator of lipid, glucose, and energy metabolism, as well as stress responses. While promising results have been shown with FGF21 analogs in metabolic disease, its exact role in kidney function remains poorly understood.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Health Care Sciences & Services
Laura Mortelmans, Eva Goossens, Anne-Marie De Cock, Mirko Petrovic, Patricia van den Bemt, Tinne Dilles
Summary: This study aimed to develop recommendations for healthcare providers to support patients with medication self-management problems. Through three phases of research, 20 medication self-management problems were identified, and 67 relevant recommendations were established. These recommendations can serve as a resource for healthcare providers to support patients with medication self-management problems.
Review
Pharmacology & Pharmacy
Silvana Nader Nagib, Saeed Abdelwahab, Ghada Essam El-Din Amin, Mohamed Farouk Allam
Summary: Chronic kidney disease (CKD) is a global public health concern with potentially greater burden in developing countries, where systematic screening and early intervention by primary care are crucial to prevent complications and reduce mortality.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Review
Education, Scientific Disciplines
Sirimalla Shivaprasad, Uday Venkat Mateti, Pradeep Shenoy, Chakrakodi Shashidhara Shastry, Sreedhar Dharmagadda
Summary: Medication therapy management (MTM) involves steps such as medication therapy review, personal medication record, medication-related action plan, intervention or referral, and documentation, which can improve patient knowledge on medicines, decrease non-adherence, and increase efficacy. Studies have shown the positive impact of MTM on geriatric, pediatric, and chronically ill patients, as well as those on polypharmacy.
PHARMACY EDUCATION
(2021)
Review
Pharmacology & Pharmacy
Silvana Nader Nagib, Saeed Abdelwahab, Ghada Essam El-Din Amin, Mohamed Farouk Allam
Summary: Chronic kidney disease is a global public health concern with potentially greater burden in developing countries. Early identification and management are crucial for preventing complications.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Review
Medicine, General & Internal
Peter R. Corridon
Summary: The increasing worldwide prevalence of acute and chronic kidney diseases has led to a higher demand for renal replacement therapy. However, the limited availability of suitable kidneys for transplantation has prompted the search for alternative strategies to alleviate the health and economic burdens associated with these conditions. Significant efforts have been made to explore regenerative approaches that can enhance the current management of renal injury, such as gene- and cell-based therapies. These approaches, utilizing technologies like recombinant peptides/proteins, gene, cell, organoid, and RNAi, have shown promising outcomes in experimental models. Moreover, research has been conducted to improve our understanding of the complex structure of the kidney, allowing for more efficient gene- and cell-based techniques. This manuscript aims to communicate the development of such therapies by identifying the vectors and delivery routes necessary for successful exogenous transgene incorporation in the treatment of acute and chronic kidney diseases.
FRONTIERS IN MEDICINE
(2023)
Review
Urology & Nephrology
Sonal Singh
Summary: The purpose of this review is to summarize recent evidence on drugs that increase the risk of nephrotoxicity, progression of chronic kidney disease (CKD), or drug-induced harm in CKD patients. Several medications increase the risk of acute kidney injury or CKD progression, and it is important to pay close attention to selecting appropriate doses or safer alternatives to reduce the risk of drug-induced harm in CKD patients.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Article
Urology & Nephrology
Manon J. M. van Oosten, Dan Koning, Susan J. J. Logtenberg, Martijn J. H. Leegte, Henk J. G. Bilo, Marc H. Hemmelder, Kitty J. Jager, Vianda S. Stel
Summary: This study investigated the prevalence of chronic antidepressant use among chronic kidney disease patients in the Netherlands. It found that the prevalence of chronic antidepressant prescription was significantly higher in CKD patients with and without kidney replacement therapy compared to controls. The use of antidepressant medication was more common in female patients and those aged 45-64 years, but not associated with socio-economic status.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Ming-Tso Yan, Chia-Ter Chao, Shih-Hua Lin
Summary: Chronic kidney disease (CKD) is characterized by irreversible structural or functional kidney damages, increasing the risk of poor outcomes. Due to the heterogeneous origins and uncertain pathogenesis, efficacious therapies for CKD remain challenging. Therefore, prevention of CKD progression and complications, as well as controlling acute kidney injury, are crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Wendy L. St Peter
SEMINARS IN DIALYSIS
(2015)
Article
Urology & Nephrology
Wendy L. St Peter, Akeem A. Yusuf, Thy Do, Kimberly A. Lowe, Jiannong Liu, Kimberly M. Nieman, Brian D. Bradbury, Allan J. Collins
Review
Nutrition & Dietetics
Lori D. Wazny, Stewart Nadurak, Cali Orsulak, Lori Giles-Smith, Navdeep Tangri
JOURNAL OF RENAL NUTRITION
(2016)
Letter
Urology & Nephrology
Wendy L. St Peter, Eric D. Weinhandl, Michael F. Flessner
AMERICAN JOURNAL OF KIDNEY DISEASES
(2013)
Editorial Material
Urology & Nephrology
Louise M. Moist, Stephan Troyanov, Colin T. White, Lori D. Wazny, Jo-Anne Wilson, Phil McFarlane, Lori Harwood, Manish M. Sood, Steven D. Soroka, Adam Bass, Braden J. Manns
AMERICAN JOURNAL OF KIDNEY DISEASES
(2013)
Article
Urology & Nephrology
Allan J. Collins, Robert N. Foley, Charles Herzog, Blanche Chavers, David Gilbertson, Charles Herzog, Areef Ishani, Kirsten Johansen, Bertram Kasiske, Nancy Kutner, Jiannong Liu, Wendy St. Peter, Shu Ding, Haifeng Guo, Allyson Kats, Kenneth Lamb, Shuling Li, Suying Li, Tricia Roberts, Melissa Skeans, Jon Snyder, Craig Solid, Bryn Thompson, Eric Weinhandl, Hui Xiong, Akeem Yusef, David Zaun, Cheryl Arko, Shu-Cheng Chen, Frank Daniels, James Ebben, Eric Frazier, Christopher Hanzlik, Roger Johnson, Daniel Sheets, Xinyue Wang, Beth Forrest, Edward Constantini, Susan Everson, Paul Eggers, Lawrence Agodoa
AMERICAN JOURNAL OF KIDNEY DISEASES
(2013)
Article
Urology & Nephrology
Akeem A. Yusuf, Benjamin L. Howell, Christopher A. Powers, Wendy L. St. Peter
AMERICAN JOURNAL OF KIDNEY DISEASES
(2014)
Article
Urology & Nephrology
Akeem A. Yusuf, Eric D. Weinhandl, Wendy L. St Peter
AMERICAN JOURNAL OF KIDNEY DISEASES
(2014)
Review
Urology & Nephrology
Britt B. Newsome, Ryan D. Kilpatrick, Jiannong Liu, David Zaun, Craig A. Solid, Kimberly Nieman, Wendy L. St. Peter
AMERICAN JOURNAL OF NEPHROLOGY
(2013)
Article
Urology & Nephrology
Ryan D. Kilpatrick, Britt B. Newsome, David Zaun, Jiannong Liu, Craig A. Solid, Kimberly Nieman, Wendy L. St Peter
AMERICAN JOURNAL OF NEPHROLOGY
(2013)
Article
Urology & Nephrology
Tariq Shafi, Stephen M. Sozio, Karen J. Bandeen-Roche, Patti L. Ephraim, Jason R. Luly, Wendy L. St Peter, Aidan McDermott, Julia J. Scialla, Deidra C. Crews, Navdeep Tangri, Dana C. Miskulin, Wieneke M. Michels, Bernard G. Jaar, Charles A. Herzog, Philip G. Zager, Klemens B. Meyer, Albert W. Wu, L. Ebony Boulware
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2014)
Letter
Urology & Nephrology
Jiannong Liu, Eric D. Weinhandl, Allan J. Collins, Wendy L. St Peter
KIDNEY INTERNATIONAL
(2013)
Review
Pharmacology & Pharmacy
Wendy L. St Peter, Lauren E. Odum, Adam T. Whaley-Connell
Article
Urology & Nephrology
Wendy L. St Peter, Stephen M. Sozio, Tariq Shafi, Patti L. Ephraim, Jason Luly, Aidan McDermott, Karen Bandeen-Roche, Klemens B. Meyer, Deidra C. Crews, Julia J. Scialla, Dana C. Miskulin, Navdeep Tangri, Bernard G. Jaar, Wieneke M. Michels, Albert W. Wu, L. Ebony Boulware