Article
Pharmacology & Pharmacy
Aiya Qin, Jiaxing Tan, Wen Hu, Yuan Liu, Lin Chen, Yi Tang, Wei Qin
Summary: This prospective study investigated the benefits of oral energy supplementation (OES) in hemodialysis patients with protein-energy wasting (PEW). The results showed that OES significantly improved serum albumin, hemoglobin, and dietary energy intake, as well as enhanced nutritional status and quality of life. No electrolyte disorders or dyslipidemia were observed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Sinee Disthabanchong, Sarunya Saeseow, Sirote Khunapornphairote, Ronnarat Suvikapakornkul, Yodying Wasutit, Jumroon Tungkeeratichai
Summary: Parathyroidectomy is associated with improvement in nutritional status in maintenance hemodialysis patients, especially for those with severe hyperparathyroidism. This finding is crucial as protein-energy wasting is common in kidney failure patients and can have negative impacts on survival and outcomes.
FRONTIERS IN MEDICINE
(2023)
Article
Nutrition & Dietetics
Kimiaki Takagi, Hiroshi Takahashi, Tomomi Miura, Kasumi Yamagiwa, Kota Kawase, Yuka Muramatsu-Maekawa, Takuya Koie, Masashi Mizuno
Summary: This study investigated the prognostic value of the Controlling Nutritional Status (CONUT) score in patients just initiating dialysis for chronic kidney disease (CKD). The CONUT score was found to be a simplified surrogate marker that could predict all-cause mortality and infectious-disease mortality in CKD patients just initiating dialysis.
Review
Nutrition & Dietetics
Yoshihiko Kanno, Eiichiro Kanda, Akihiko Kato
Summary: Patients receiving dialysis therapy often face nutritional challenges, yet medical staff in Japan lack training and support in nutritional management. Recent studies suggest that under conditions of low nutrition, salt intake should not be restricted for frail or dialysis patients, and protein consumption should be targeted at 0.9 to 1.2 g/kg/day. The Nutritional Risk Index-Japanese Hemodialysis (NRI-JH) is recommended by the Japanese Society of Dialysis Therapy to screen for malnutrition in older patients.
Article
Multidisciplinary Sciences
Ziwei Mei, Bin Zhu, Xiaoli Sun, Yajie Zhou, Yuanyuan Qiu, Xiaolan Ye, Hongjuan Zhang, Chunlan Lu, Jun Chen, Hong Zhu
Summary: This study developed a nomogram to predict the risk of protein-energy wasting (PEW) in patients undergoing peritoneal dialysis (PD) by collecting data from ESRD patients. The nomogram showed good predictive performance and clinical utility. It can provide valuable evidence for PEW prevention and decision-making.
Article
Urology & Nephrology
Mohamed Sary Gharib, Mariem Shaker Nazeih, Tamer Wahid El Said
Summary: This study aimed to assess the effect of intradialytic oral nutritional supplement (ONS) on nutritional markers in chronic hemodialysis patients. The results showed that intradialytic ONS, along with dietary counseling, improved the nutritional status and inflammation in these patients.
Article
Nutrition & Dietetics
Marta Arias-Guillen, Silvia Collado, Elisabeth Coll, Jordi Carreras, Loreley Betancourt, Barbara Romano, Marisol Fernandez, Veronica Duarte, Julia Garro, Jordi Soler, Juan Carlos Gonzalez, Jordi Calabia
Summary: This study used a new online tool to investigate the prevalence of protein-energy wasting (PEW) in dialysis patients in Catalonia, Spain, and found that MIS is the most sensitive score for diagnosing PEW.
Article
Nutrition & Dietetics
Andreja Ocepek, Robert Ekart, Petra Povalej Brzan, Sebastjan Bevc
Summary: Protein-energy wasting is a common and serious co-morbidity in haemodialysis patients. This study examines the effect of oral nutritional supplements on the nutritional status of HD patients after 12 months.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Sharmela Sahathevan, Tilakavati Karupaiah, Ban-Hock Khor, Birinder Kaur Sadu Singh, Zulfitri Azuan Mat Daud, Enrico Fiaccadori, Alice Sabatino, Karuthan Chinna, Abdul Halim Abdul Gafor, Sunita Bavanandan, Ravindran Visvanathan, Rosnawati Yahya, Zaimi Wahab, Bak-Leong Goh, Zaki Morad, Boon Cheak Bee, Hin Seng Wong
Summary: This study compared the effects of combined treatment (ONS + NC) vs. NC alone on muscle status and nutritional parameters in HD patients with PEW, showing that the combined treatment group had significant improvements in muscle status and nutritional parameters, with fewer patients diagnosed with PEW at the end of the study.
FRONTIERS IN NUTRITION
(2021)
Article
Urology & Nephrology
Jessica Machado, Roberta Fontanive Miyahira, Monica Marques, Nathalia Moura-Nunes, Renata Rangel Guimaraes, Lilia Zago, Isabelle Santana, Maurilo Leite Junior, Carla Maria Avesani
Summary: This study developed two non-industrial food products for HD patients, one of which is a protein-enriched muffin with fine herbs. The protein-enriched muffins had higher protein content and lower carbohydrate content compared to the standard formulation and were well-accepted by patients.
JOURNAL OF NEPHROLOGY
(2021)
Article
Pediatrics
Hagar El-Saied Saad El-Serw, Dina Abdel Rasoul Helal Bassiouni, Angy Adel Al-Wakeil, Ragaa Shawky Aly Ibrahim El-Masry, Ashraf Mohamed Abd E. I. Basset Bakr
Summary: IDPN is proposed as an effective method for preventing and treating malnutrition in children with CKD 5, with significant improvements observed in the intervention group compared to the control group. Further multi-centric studies with larger sample size and longer follow-up duration are recommended.
PEDIATRIC NEPHROLOGY
(2021)
Article
Nutrition & Dietetics
Yoshikazu Miyasato, Ramy M. Hanna, Jun Morinaga, Masashi Mukoyama, Kamyar Kalantar-Zadeh
Summary: Prognostic nutritional index (PNI), calculated from serum albumin level and total lymphocyte count, is a useful prognostic marker for both cancer patients and patients undergoing hemodialysis.
Article
Medicine, General & Internal
Junko Ishida, Akihiko Kato
Summary: Patients on hemodialysis (HD) are at a higher risk of protein-energy wasting (PEW) due to decreased energy and protein intake and loss of nutrients in the dialysis effluent. Several nutritional screening methods are available, but their use in HD patients varies. Japanese patients on HD have a specific nutritional risk index based on modified PEW criteria. These screening tools help evaluate dietary intake and provide dietary advice, with options including oral supplementation and intradialytic parenteral nutrition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Ksymena Lesniak, Aleksandra Rymarz, Maria Sobol, Jolanta Dymus, Agnieszka Wozniak-Kosek, Stanislaw Niemczyk
Summary: The study found that circulating sex steroids and nutritional parameters are associated with prognosis in patients with chronic kidney disease, and low levels of testosterone may increase the risk of death.
Review
Urology & Nephrology
Laetitia Koppe, Robert H. Mak
Summary: Protein energy wasting (PEW) is defined as nutritional disorders in patients with acute kidney injury and chronic kidney disease. The use of terms like cachexia or malnutrition in other chronic diseases can cause confusion. The pathways involved in cachexia/malnutrition and PEW are common, but the specific conditions in kidney diseases justify the term PEW.
SEMINARS IN NEPHROLOGY
(2023)
Article
Urology & Nephrology
Sandeep Brar, Kathleen D. Liu, Alan S. Go, Raymond K. Hsu, Vernon M. Chinchilli, Steven G. Coca, Amit X. Garg, Jonathan Himmelfarb, T. Alp Ikizler, James Kaufman, Paul L. Kimmel, Chirag R. Parikh, Edward D. Siew, Lorraine B. Ware, Hui Zeng, Chi-yuan Hsu
Summary: The study found that the use of ACEI/ARB after hospital discharge did not increase the risk of recurrent AKI in patients with or without previous AKI during hospitalization. Additionally, there were no significant differences in the risks of death, kidney disease progression, and adjudicated heart-failure events between patients who did and did not experience AKI during hospitalization.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medicine, Research & Experimental
Jeremy Puthumana, Heather Thiessen-Philbrook, Leyuan Xu, Steven G. Coca, Amit X. Garg, Jonathan Himmelfarb, Pavan K. Bhatraju, T. Alp Ikizler, Edward D. Siew, Lorraine B. Ware, Kathleen D. Liu, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Vernon M. Chinchilli, Lloyd G. Cantley, Chirag R. Parikh
Summary: The study found that levels of MCP-1 and YKL-40 measured at 3 months after hospitalization were associated with long-term risk of kidney failure, while UMOD levels were linked with decreased risk of kidney injury. Using a multimarker score provided better accuracy in predicting patients' risk of kidney disease progression compared to traditional clinical variables.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Editorial Material
Urology & Nephrology
T. Alp Ikizler
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Editorial Material
Urology & Nephrology
T. Alp Ikizler, Jonathan Himmelfarb
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Sherry G. Mansour, Pavan K. Bhatraju, Steven G. Coca, Wassim Obeid, Francis P. Wilson, Ian B. Stanaway, Yaqi Jia, Heather Thiessen-Philbrook, Alan S. Go, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Chi-yuan Hsu, Amit X. Garg, W. Brian Reeves, Kathleen D. Liu, Paul L. Kimmel, James S. Kaufman, Mark M. Wurfel, Jonathan Himmelfarb, Samir M. Parikh, Chirag R. Parikh, ASSESS-AKI Consortium
Summary: A higher Angpt-1:Angpt-2 ratio is strongly associated with reduced risk of CKD progression, heart failure, and mortality in patients with AKI.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Hematology
Melis Sahinoz, James M. Luther, Mona Mashayekhi, Dae Kwang Jung, T. Alp Ikizler, Brian G. Engelhardt
Summary: Cancer survivors have an increased risk of developing type 2 diabetes, and the interaction between cancer and body mass index (BMI) can affect insulin sensitivity and glucose regulation.
Editorial Material
Nutrition & Dietetics
T. Alp Ikizler
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Editorial Material
Urology & Nephrology
Osama El Shamy, T. Alp Ikizler
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Nan Guan, Hanako Kobayashi, Ken Ishii, Olena Davidoff, Feng Sha, Talat A. Ikizler, Chuan-Ming Hao, Navdeep S. Chandel, Volker H. Haase
Summary: This study investigates the role of mitochondrial electron transport in kidney homeostasis by inactivating a subunit of mitochondrial complex III in kidney progenitor cells. The results show that mitochondrial oxidative metabolism is critical for kidney development, and inactivation of specific proteins can lead to severe kidney dysplasia or smaller functional kidneys.
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Urology & Nephrology
Rengin Elsurer Afsar, Talat Alp Ikizler
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Steven Menez, Yumeng Wen, Leyuan Xu, Dennis G. Moledina, Heather Thiessen-Philbrook, David Hu, Wassim Obeid, Pavan K. Bhatraju, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Amit X. Garg, Alan S. Go, Kathleen D. Liu, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Steven G. Coca, Lloyd G. Cantley, Chirag R. Parikh
Summary: Urinary epidermal growth factor (EGF) may serve as a biomarker for tubular function and can be used to assess the risk of chronic kidney disease (CKD) after hospitalization. Higher urinary EGF concentrations three months post-discharge are associated with a reduced risk of major adverse kidney events (MAKE), such as CKD incidence, progression, or kidney failure.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Finnian R. Mc Causland, Jesse Y. Hsu, Jonathan Himmelfarb, Talat Alp Ikizler, Dominic S. Raj, Rajnish Mehrotra, Sushrut S. Waikar, Paul L. Kimmel, Alan S. Kliger, Laura M. Dember, David M. Charytan
Summary: In a post hoc analysis, it was found that spironolactone treatment resulted in a higher frequency of bradycardia and conduction blocks in patients receiving maintenance hemodialysis. Close monitoring is necessary for these patients while awaiting definitive trial results.
Review
Urology & Nephrology
Lale Ertuglu, Abdulmecit Yildiz, Jorge Gamboa, T. Alp Ikizler
Summary: Sarcopenia, characterized by decreased muscle function and mass, is common in patients with moderate to advanced chronic kidney disease (CKD) and is associated with poor clinical outcomes. Mitochondrial dysfunction is proposed as one of the underlying mechanisms, which is noticeable from the early stages and correlated with disease severity. Uremic toxins, oxidative stress, and systemic inflammation play a role in the development of mitochondrial dysfunction. Therapeutic interventions targeting mitochondrial function, such as coenzyme Q and cardiolipin-targeted peptides, have been tested in early studies. Aerobic exercise, although effective in healthy adults, is not as effective in advanced CKD patients, potentially due to impaired activation of mitochondrial biogenesis. Further research is needed to better understand the pathogenesis of mitochondrial dysfunction and develop targeted therapies for sarcopenia in CKD patients.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Urology & Nephrology
Juan Pablo Arroyo, Elvis A. Akwo, Andrew S. Terker, Aseel Alsouqi, Gautam Bhave, Raymond C. Harris, Adriana M. Hung, T. Alp Ikizler
Summary: The study found a significant correlation between peripheral insulin resistance and elevated copeptin levels in patients with CKD, with a 39% increase in copeptin levels for every 1 SD decrease in insulin sensitivity. Further research into how peripheral insulin resistance and elevated vasopressin affect CKD progression could provide valuable insights.
Article
Urology & Nephrology
Dominic S. Raj, Michael B. Sohn, David M. Charytan, Jonathan Himmelfarb, T. Alp Ikizler, Rajnish Mehrotra, Ali Ramezani, Renu Regunathan-Shenk, Jesse Y. Hsu, J. Richard Landis, Hongzhe Li, Paul L. Kimmel, Alan S. Kliger, Laura M. Dember
Summary: The study found that there is greater variability in gut microbiome and metabolomic composition between individuals with ESKD than within individuals. Treatment with p-inulin was well tolerated and showed signs of increasing microbiome diversity.