Article
Multidisciplinary Sciences
Adam R. Fenton, Thomas A. Jongens, Erika L. F. Holzbaur
Summary: Mitochondria are transported along microtubules by opposing kinesin and dynein motors, linked by TRAK adaptor proteins. TRAK2 activates kinesin-1 for transport toward the plus-end of microtubules and acts as a dynein activating adaptor for transport toward the minus-end. At a sufficient level, the dynein-binding protein LIS1 is necessary for efficient dynein-mediated TRAK2 transport. TRAK2 forms a complex containing both kinesin-1 and dynein-dynactin, functionally linking these motors and coordinating their activities for proper mitochondrial transport.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Sarah A. Bennison, Sara M. Blazejewski, Xiaonan Liu, Gal Hacohen-Kleiman, Shlomo Sragovich, Sofia Zoidou, Olga Touloumi, Nikolaos Grigoriadis, Illana Gozes, Kazuhito Toyo-oka
Summary: Defective neuritogenesis is a contributing mechanism in neurodevelopmental disorders, particularly in ADNP syndrome. Adnp is localized to the cytoplasm by binding with 14-3-3 proteins, and its knockdown inhibits neurite formation. Adnp deficiency leads to morphological and functional abnormalities in the cortex, including increased dendrite number and axon length.
MOLECULAR PSYCHIATRY
(2023)
Review
Cell Biology
Ping Zhou, Guiwen Yang, Wei Xie
Summary: The remodeling of microtubules during cell differentiation is a critical process that involves microtubule-binding proteins, cell junctions, and centrosomes. Recent studies have shed light on the dynamic changes in microtubule organization and functions during cell differentiation, revealing the regulatory mechanisms and physiological functions of this process.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Brett A. McCray, Erika Diehl, Jeremy M. Sullivan, William H. Aisenberg, Nicholas W. Zaccor, Alexander R. Lau, Dominick J. Rich, Benedikt Goretzki, Ute A. Hellmich, Thomas E. Lloyd, Charlotte J. Sumner
Summary: TRPV4 interacts with RhoA, affecting cell structure. The neuropathy effects of TRPV4 are related to incorrect binding with RhoA. Inhibition of RhoA can restore neurite length.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Jayne Aiken, Erika L. F. Holzbaur
Summary: The development and proper function of the brain require the intricate formation of neuronal circuitry through synaptic connections between neurons, which must be maintained over a lifetime. Accurate trafficking of presynaptic and postsynaptic components, as well as readily accessible energy stores from localized mitochondria, are crucial for synapse-specific delivery and plasticity. Recent research has shed light on the importance of local regulation of cytoskeletal dynamics and organelle trafficking in establishing and maintaining neuronal circuitry.
Article
Multidisciplinary Sciences
Mariko Umemura, Yasuyuki Kaneko, Ryoko Tanabe, Yuji Takahashi
Summary: Deficiency of ATF5 in mice leads to abnormal behaviors, which are associated with impaired cortical development and radial migration.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Lorenzo Gesuita, Anna Cavaccini, Ali Ozgur Argunsah, Emilia Favuzzi, Leena Ali Ibrahim, Tevye Jason Stachniak, Martina De Gennaro, Sebastian Utz, Melanie Greter, Theofanis Karayannis
Summary: Microglia play a crucial role in the development of inhibitory networks, especially in the proper development of SST+ cell synapses. The molecules CX3CL1 and CXCL12 have opposing effects on the elaboration of SST+ cell axons. In terms of cortical activity development, microglia are essential for the activation of SST+ cells.
Article
Biology
Mengjing Bao, Ruth E. Doerig, Paula Maria Vazquez-Pianzola, Dirk Beuchle, Beat Suter
Summary: In this study, the glutamylation of a-tubulin isotypes in Drosophila ovaries was investigated. It was found that the C-terminal ends of alpha Tub84B/D were glutamylated, while alpha Tub67C was not. TTLL5 was identified as the protein responsible for mono- and poly-glutamylation of alpha Tub84B/D and its proper localization. This study also demonstrated the dependence of kinesin-1 distribution, as well as other cellular functions such as axonal transport and ooplasmic streaming, on TTLL5 and alpha-tubulin glutamylation.
Article
Genetics & Heredity
Changuk Chung, Xiaoxu Yang, Taejeong Bae, Keng Ioi Vong, Swapnil H. Mittal, Catharina Donkels, H. Westley Phillips, Zhen Li, Ashley P. L. Marsh, Martin Breuss, Laurel Ball, Camila Araujo Bernardino Garcia, Renee George, Jing Gu, Mingchu Xu, Chelsea Barrows, Kiely James, Valentina Stanley, Anna Nidhiry, Sami Khoury, Gabrielle Howe, Emily Riley, Xin Xu, Brett Copeland, Yifan G. Wang, Se Hoon L. Kim, Hoon-Chul W. Kang, Andreas Schulze-Bonhage, Carola Haas, Horst Urbach, Marco Prinz, David A. Limbrick, Christina Gurnett, Matthew C. Smyth, Shifteh M. Sattar, Mark B. Nespeca, David V. Gonda, Katsumi Y. Imai, Yukitoshi E. Takahashi, Hsin-Hung B. Chen, Jin-Wu Tsai, Valerio Conti, Renzo Guerrini, Orrin Devinsky, Wilson Silva, Helio M. Machado, Gary Mathern, Alexej Abyzov, Sara Baldassari, Stephanie Baulac, Joseph G. Gleeson
Summary: Malformations of cortical development (MCD) are neurological disorders caused by somatic mosaic mutations during embryogenesis, leading to intractable epilepsy. This study identified 69 mutated genes from 283 brain resections and investigated their functional roles using various techniques. Genotype-phenotype correlation analysis revealed specific gene sets associated with different pathophysiological and clinical phenotypes of MCD. The spatiotemporal expression patterns of mutated genes in control and patient brains suggest their critical roles in excitatory neurogenesis and neuronal hyperexcitability.
Article
Chemistry, Multidisciplinary
Xiao-wei Li, Jian-hua Ran, Hong Zhou, Jin-zhao He, Zhi-wei Qiu, Shu-yuan Wang, Meng-na Wu, Shuai Zhu, Yong-pan An, Ang Ma, Min Li, Ya-zhu Quan, Nan-nan Li, Chao-qun Ren, Bao-xue Yang
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease, and the development of cysts is associated with abnormal proliferation of epithelial cells, with the primary cilia being a therapeutic target. This study found that the anti-tumor agent 1-Indanone could inhibit the growth and development of renal cysts by promoting tubulin polymerization and down-regulating the expression of related proteins in cystic epithelial cilia. Additionally, 1-Indanone inhibited cystic cell proliferation by down-regulating ciliary coordinated signaling pathways.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Multidisciplinary Sciences
Dong Jin Mun, Bon Seong Goo, Bo Kyoung Suh, Ji-Ho Hong, Youngsik Woo, Soo Jeong Kim, Seunghyun Kim, Su Been Lee, Yubin Won, Jin Yeong Yoo, Eunbyul Cho, Eun Jin Jang, Truong Thi My Nhung, Hong Minh Triet, Hongyul An, Haeryun Lee, Minh Dang Nguyen, Seung-Yeol Park, Seung Tae Baek, Sang Ki Park
Summary: In this study, the Gcap14-Ndel1 complex is identified as a fundamental regulator of cytoskeletal remodeling during neurodevelopment, including neuronal process elongation and migration. Deficiency of Gcap14 leads to impaired cortical lamination and defective neuronal migration. The interaction between Gcap14 and Ndel1 effectively corrects the downregulation of microtubule dynamics and the defects in neuronal migration caused by Gcap14 deficiency.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Ruiyan Cen, Liqun Wang, Yongqing He, Chenda Yue, Yang Tan, Lingfei Li, Xia Lei
Summary: This study reveals an important role of stathmin in the migration and proliferation of dermal fibroblasts. Stathmin is shown to increase with p38/MAPK pathway activation in response to lipopolysaccharide stimulation, resulting in microtubule depolymerization and increased migration and proliferation of dermal fibroblasts. Targeting stathmin or the p38/MAPK pathway could be a potential strategy for clinical interventions in wound healing.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Catherine Fleitas, Pau Marfull-Oromi, Disha Chauhan, Daniel del Toro, Blanca Peguera, Bahira Zammou, Daniel Rocandio, Rudiger Klein, Carme Espinet, Joaquim Egea
Summary: Neuron migration is important in nervous system development, with FLRTs controlling the distribution of cortical inhibitory interneurons through Unc5 receptors, potentially impacting the development of psychiatric disorders.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Environmental Sciences
Ling Yang, Jiao Zou, Zhenle Zang, Liuyongwei Wang, Zhulin Du, Dandan Zhang, Yun Cai, Minghui Li, Qiyou Li, Junwei Gao, Haiwei Xu, Xiaotang Fan
Summary: Using a human cerebral organoid model, researchers found that DEHP exposure inhibited cell proliferation and increased apoptosis, impairing the morphogenesis of the human cerebral cortex. DEHP exposure disrupted neurogenesis and neural progenitor migration, possibly due to dysplasia of radial glia cells. RNA sequencing analysis showed that DEHP-induced disorder in cell-extracellular matrix interactions might play a crucial role in the neurodevelopment of human cerebral organoids.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biology
Alessia Caramello, Christophe Galichet, Karine Rizzoti, Robin Lovell-Badge
Summary: During embryonic development, timely regulation of the switch between radial glial cells, neurons, and astrocytes is crucial for coordinated interactions in the brain. The deletion of the SOX9 gene in early mouse brain development resulted in compromised dentate gyrus development, highlighting the importance of SOX9 in regulating astroglial potential acquisition in the cortical hem. This study demonstrates the formation of a local network between astrocytic and neuronal progenitors from adjacent domains, essential for brain morphogenesis.
Article
Anatomy & Morphology
Saeko Morishita, Kaei Sai, Seishi Maeda, Sachi Kuwahara-Otani, Yusuke Minato, Hideshi Yagi
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Yusuke Minato, Sachi Kuwahara-Otani, Seishi Maeda, Hideshi Yagi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Neurosciences
Kyosuke Yamanishi, Nobutaka Doe, Keiichiro Mukai, Kaoru Ikubo, Takuya Hashimoto, Noriko Uwa, Miho Sumida, Yosif El-Darawish, Naomi Gamachi, Wen Li, Sachi Kuwahara-Otani, Seishi Maeda, Yuko Watanabe, Tetsu Hayakawa, Hiromichi Yamanishi, Tomohiro Matsuyama, Hideshi Yagi, Haruki Okamura, Hisato Matsunaga
Article
Biochemistry & Molecular Biology
Kensuke Matsumura, Masayuki Baba, Kazuki Nagayasu, Kana Yamamoto, Momoka Kondo, Kohei Kitagawa, Tomoya Takemoto, Kaoru Seiriki, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Toshihiko Kuriu, Tokuichi Iguchi, Makoto Sato, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Kensuke Matsumura, Kaoru Seiriki, Shota Okada, Masashi Nagase, Shinya Ayabe, Ikuko Yamada, Tamio Furuse, Hirotoshi Shibuya, Yuka Yasuda, Hidenaga Yamamori, Michiko Fujimoto, Kazuki Nagayasu, Kana Yamamoto, Kohei Kitagawa, Hiroki Miura, Nanaka Gotoda-Nishimura, Hisato Igarashi, Misuzu Hayashida, Masayuki, Momoka Kondo, Shigeru Hasebe, Kosei Ueshima, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Tokuichi Iguchi, Makoto Sato, Shun Yamaguchi, Masaru Tamura, Shigeharu Wakana, Atsushi Yoshiki, Ayako M. Watabe, Hideyuki Okano, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
NATURE COMMUNICATIONS
(2020)
Article
Anatomy & Morphology
Yoshiyuki Onishi, Haruka Hisato, Seishi Maeda, Yusuke Minato, Sachi Kuwahara-Otani, Hideshi Yagi
Summary: This study identified the anatomical features and physiological function of Pacinian corpuscles around the deep vessels in the upper arm using immunohistochemical methods. The results showed that Pacinian corpuscles are densely distributed on the distal side of deep vessels and function as depth sensory sensors by detecting vibration from blood vessels.
JOURNAL OF ANATOMY
(2021)
Article
Neurosciences
Tokuichi Iguchi, Yuichiro Oka, Misato Yasumura, Minoru Omi, Kazuki Kuroda, Hideshi Yagi, Min-Jue Xie, Manabu Taniguchi, Martin Bastmeyer, Makoto Sato
Summary: The expression and repulsive activities of EphA7 and EfnA5 in the cortex and basilar pons are crucial for segregating collateral extensions and directing corticopontine projections in mice.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Yuichiro Oka, Miyuki Doi, Manabu Taniguchi, Sheena Y. X. Tiong, Hisanori Akiyama, Takuto Yamamoto, Tokuichi Iguchi, Makoto Sato
Summary: The study found that dual-projection neurons in the mouse neocortex make up a significant portion of the association projections to the primary motor cortex, supporting a directed guidance mechanism in long-range corticocortical circuit formation. The developmental processes of these association projections, especially in the early stages before reaching the target areas, remain unknown.
Article
Cell Biology
Seishi Maeda, Yusuke Minato, Sachi Kuwahara-Otani, Hiroki Yamanaka, Mitsuyo Maeda, Yosky Kataoka, Hideshi Yagi
Summary: This study investigated the spatial and molecular composition associations of renal Schwann cells supporting the nerve terminals in the kidney. It found that renal nerve terminals could contact their effectors via integrins and may have a structure suitable for releasing neurotransmitters.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Biology
Mai Quynh Nguyen, Manabu Taniguchi, Misato Yasumura, Tokuichi Iguchi, Makoto Sato
Summary: Actin-based protrusions called cytonemes, which play important roles in cell communication, are formed through a molecular mechanism that involves the LAR receptor protein. This study shows that LAR dimerization triggers the formation of longer and more branched cytoneme-like protrusions, emphasizing the significance of LAR and its dimerization in cell signaling.
Article
Psychiatry
Kyosuke Yamanishi, Nobutaka Doe, Keiichiro Mukai, Takuya Hashimoto, Naomi Gamachi, Masaki Hata, Yuko Watanabe, Chiaki Yamanishi, Hideshi Yagi, Haruki Okamura, Hisato Matsunaga
Summary: IL18-deficient mice are more sensitive to acute stress and have a prolonged response. In addition, neural inflammation and augmentation of glucocorticoid signals caused by stress are more intense in IL18-deficient mice.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Min-Jue Xie, Yasuyuki Ishikawa, Hideshi Yagi, Tokuichi Iguchi, Yuichiro Oka, Kazuki Kuroda, Keiko Iwata, Hiroshi Kiyonari, Shinji Matsuda, Hideo Matsuzaki, Michisuke Yuzaki, Yugo Fukazawa, Makoto Sato
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Shenglan Wang, Kimiko Kobayashi, Yoko Kogure, Hiroki Yamanaka, Satoshi Yamamoto, Hideshi Yagi, Koichi Noguchi, Yi Dai
Article
Anatomy & Morphology
Seishi Maeda, Mayumi Fujihira, Yusuke Minato, Sachi Kuwahara-Otani, Koichi Tanaka, Tetsu Hayakawa, Hideshi Yagi
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2017)
