Article
Food Science & Technology
Wei Luo, Jinqiu Wang, Ling Sun, Rui Li, Di Wu, Jie Tang, Jiamin Zhang, Fang Geng
Summary: The study found that ultrasound disrupted the cellular structure and permeability of Salmonella bacteria, leading to accumulation of reactive oxygen species and a reduction in ATP and ATPase activity. These adverse effects disrupted the metabolic process in Salmonella cells and enhanced the lethality of chlorine dioxide.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Qifeng Deng, Sidi Yang, Lanqing Sun, Kai Huang, Kedi Dong, Yuan Zhu, Yu Cao, Yuanyuan Li, Shuyan Wu, Rui Huang
Summary: Maintaining host iron homeostasis is crucial for nutritional immunity, and this study reveals a novel role of NLRP6 in regulating host iron metabolism and bacterial infection resistance. The mechanism involves NRF2 regulation through NLRP6/AKT interaction and AKT phosphorylation, affecting NRF2 nuclear translocation and KEAP1 transcription.
Article
Microbiology
Maria G. Winter, Elizabeth R. Hughes, Matthew K. Muramatsu, Angel G. Jimenez, Rachael B. Chanin, Luisella Spiga, Caroline C. Gillis, Michael McClelland, Helene Andrews-Polymenis, Sebastian E. Winter
Summary: Salmonella utilizes formate as an electron donor to support respiration, and formate oxidation predominantly occurs in the mucus layer of the gut. The bacteria in the mucus layer have higher transcription levels of formate dehydrogenases and pyruvate-formate lyase compared to those in the lumen. Our findings enhance understanding of microbial metabolism in different gut microenvironments and may have implications for other enteric pathogens.
Article
Immunology
Soyeon Park, Bogyo Jung, Eunsuk Kim, Hyunjin Yoon, Tae-Wook Hahn
Summary: Non-typhoidal Salmonella (NTS) is a major cause of foodborne gastroenteritis and can cause invasive infection in humans. A live attenuated vaccine candidate, Delta fruR, was constructed and shown to provide 100% protection against NTS infection in mice. The Delta fruR mutant stimulated antibody production and reduced virulence in infected mice.
Article
Microbiology
Heng Yang, Yanhong Zhou, Qiong Luo, Chunyang Zhu, Binghu Fang
Summary: The overuse of antibiotics has led to a public health crisis, and it is urgent to develop new clinical treatment methods to combat drug resistant bacteria. This study found that exogenous L-leucine increases the killing effect of sarafloxacin on drug-resistant bacteria by stimulating their metabolic state, particularly the TCA cycle. This improvement in antibiotic efficacy suggests that reprogramming the metabolism of drug-resistant bacteria can enhance the bactericidal effect of antibiotics.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Yuanyuan Wang, Chunmei Wu, Jiacong Gao, Xudong Du, Xiangyun Chen, Mei Zhang
Summary: Salmonella enterica serovar Typhimurium triggers reprogramming of host cell metabolism and an inflammatory response during systemic infection, promoting its survival and replication. Additionally, infection by Salmonella may induce M1 and M2 polarization in macrophages, and alter the actin cytoskeleton to facilitate the formation of Salmonella-containing vacuoles.
EMERGING MICROBES & INFECTIONS
(2021)
Review
Immunology
Charlotte Hellmich, Edyta E. Wojtowicz
Summary: Normal bone marrow homeostasis relies on a steady supply of nutrients, and changes in metabolite demands can occur in response to infection and immune stress. The right balance of dietary components helps maintain normal homeostasis and cope with systemic stress. Some dietary components can also lead to chronic inflammation, impacting immune function. Optimal nutrition supports immune cell functions to effectively combat pathogens and resolve responses, while avoiding chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Nabil A. Siddiqui, Hailey A. Houson, Nitin S. Kamble, Jose R. Blanco, Robert E. O'Donnell, Daniel J. Hassett, Suzanne E. Lapi, Nalinikanth Kotagiri
Summary: The need for accurate and rapid identification of bacteria in the human body for diverse biomedical objectives is increasing. The development of a copper-64-labeled bacterial metal chelator, yersiniabactin, utilizes a highly conserved metal acquisition pathway for noninvasive and selective imaging of bacteria. This simplified strategy combines metal attachment and cell recognition functions into the same molecule, enabling the identification of specific bacterial populations, monitoring antibiotic treatment outcomes, and tracking bacteria in diverse niches in vivo.
Article
Multidisciplinary Sciences
Andrew J. Tighe, Sean Grayson, John Byrne, Sanni Hintikka, Lisa Jessen, Jake Dempsey, Lauren Browne, Mary Kelly-Quinn, Bernerd Fulanda, Neil M. Ruane, Jens Carlsson
Summary: This study reveals that Shigella bacteria are still a major cause of dysentery in sub-Saharan Africa, resulting in approximately 600,000 deaths annually. The study also highlights the potential role of wild-caught freshwater catfish as vectors for Shigella flexneri in Southern Kenya.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Ev-Marie Schuster, Maximilian W. Epple, Katharina M. Glaser, Michael Mihlan, Kerstin Lucht, Julia A. Zimmermann, Anna Bremser, Aikaterini Polyzou, Nadine Obier, Nina Cabezas-Wallscheid, Eirini Trompouki, Andrea Ballabio, Joerg Vogel, Joerg M. Buescher, Alexander J. Westermann, Angelika S. Rambold
Summary: There is a metabolic pathway regulated by TFEB between phago-lysosomes and mitochondria in macrophages, which restricts the growth of Salmonella bacteria by producing itaconate.
Review
Microbiology
Wanwu Li, Qili Ren, Ting Ni, Yifei Zhao, Zichun Sang, Renli Luo, Zhongjie Li, Sanqiang Li
Summary: This review discusses the strategies used by Salmonella to evade host cell defenses, including injecting effector proteins through secretion systems, modulating host cell immunity, metabolism, and cell cycle to enhance its survival in the host.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Engineering, Industrial
Kassem Moustafa, Zhen Hu, Zissimos P. Mourelatos, Igor Baseski, Monica Majcher
Summary: ALT is widely used to expedite product reliability analysis, but different testing levels require different resources and approaches with their own advantages and disadvantages. A novel framework is proposed using shared frailty models and Bayesian methods to combine component-level and system-level testing information for calculating system reliability effectively.
RELIABILITY ENGINEERING & SYSTEM SAFETY
(2021)
Article
Microbiology
Haihong Jia, Nannan Song, Yue Ma, Fengyu Zhang, Yingying Yue, Weiwei Wang, Cuiling Li, Hui Li, Qi Wang, Lichuan Gu, Bingqing Li
Summary: This study reveals a novel regulation process of iron acquisition mediated by UMPylator YdiU, which inhibits the binding of Fur to target DNA and activates the expression of iron uptake genes. This process is crucial for Salmonella survival within host cells and evasion of host nutritional immunity.
Article
Veterinary Sciences
Courtney M. Dewart, Michelle A. Waltenburg, Stephen Dietrich, Kimberly Machesky, Amber Singh, Eric Brandt, Sietske de Fijter
Summary: A cluster of five human Salmonella Guinea cases was identified in Ohio, with a potential association to bearded dragons. Practices such as allowing pet reptiles to roam freely in the home, cleaning reptile habitats indoors, and kissing reptiles were found to potentially increase the risk for Salmonella transmission. This study highlights the potential link between human Salmonella infections and reptiles, specifically bearded dragons.
PREVENTIVE VETERINARY MEDICINE
(2022)
Article
Microbiology
Aravindh Nagarajan, Kristin Scoggin, Jyotsana Gupta, David W. Threadgill, Helene L. Andrews-Polymenis
Summary: This study investigated the impact of host genetics on gut microbial composition using Collaborative Cross (CC) mice. The bacterial composition across different CC strains showed significant variation at the phylum level. Multiple host genes were found to influence the gut microbiome composition and homeostasis, with certain microorganisms influencing health outcomes after S. Typhimurium infection. Machine learning classifiers accurately predicted CC strains and infection outcomes using pre-infection bacterial composition data.
