Journal
CURRENT OPINION IN LIPIDOLOGY
Volume 25, Issue 5, Pages 394-399Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOL.0000000000000112
Keywords
atherosclerotic plaque; collagen; extracellular matrix; lipid retention; small leucine rich repeat proteins
Funding
- Swedish Heart-Lung Foundation
- Swedish Research Council
- Swedish Foundation for Strategic Research
- Alfred Osterlund Foundation
- Crafoord Foundation
- Vinnova
- Thelma Zoega's Foundation
- Marianne and Marcus Wallenberg Foundation
- Swedish Medical Society
- Lundstrom's foundations
- Skane university hospital
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Purpose of review The structure, composition and turnover of the extracellular matrix (ECM) as well as cell-matrix interactions are crucial in the developing atherosclerotic plaque. There is a need for further insight into specific proteins in the ECM and their functions in the developing plaque, and during the last few years a number of publications have highlighted this very important field of research. These novel findings will be addressed in the present review. Recent findings This review covers literature focused on collagen and ECM proteins interacting with collagen, and what their roles may be in plaque development. Summary Acute myocardial infarction and stroke are common diseases that cause disability and mortality, and the underlying mechanism is often the rupture of a vulnerable atherosclerotic plaque. The vascular ECM and the tissue repair in the atherosclerotic lesion are important players in plaque progression. Understanding how specific proteins in the ECM interact with cells in the plaque and affect the fate of the plaque can lead to new treatments for cardiovascular disease.
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