Review
Endocrinology & Metabolism
Marco Di Gioia, Ivan Zanoni
Summary: Endogenous oxidized phospholipids play a key role in sustaining inflammatory responses and can affect the biology and function of phagocytes, leading to the development of chronic inflammatory diseases. Understanding the mechanisms of action of these oxidized lipids is crucial for designing interventions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Pratap Karki, Konstantin G. Birukov
Summary: Previous studies have focused on the pro-inflammatory and barrier disruptive effects of lipid oxidation products in chronic vascular inflammation related to atherosclerosis, but recent evidence suggests that certain oxidized phospholipids actually have barrier protective and anti-inflammatory properties in the lung vascular endothelium. Among these, oxidized 1-palmitoyl-2-arachdonyl-sn-glycero-3-phosphocholine has been shown to enhance endothelial cell barrier properties and protect against vascular permeability induced by various agonists. Additionally, signaling mechanisms involving cytoskeletal remodeling play a significant role in the regulation of endothelial barrier function by oxidized phospholipids.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Pratap Karki, Chen-Ou Zhang, Kamoltip Promnares, Yue Li, Yunbo Ke, Anna A. Birukova, Konstantin G. Birukov
Summary: Oxidized phospholipids (OxPLs) are present in the circulation at basal levels, but during microbial infections, sepsis, and trauma, there is a significant increase in OxPLs accompanied by changes in composition. Truncated oxidized phospholipids (Tr-OxPLs) have detrimental effects on pulmonary endothelium, but their role in modulating lung injury caused by bacterial pathogens is not yet clear.
CELLULAR SIGNALLING
(2023)
Article
Hematology
Brenna D. Appleton, Sydney A. Palmer, Harrison P. Smith, Lilly E. Stephens, Amy S. Major
Summary: This study investigates the impact of oxidized phospholipid on regulatory T cells (T-regs) in atherosclerosis. The results demonstrate that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (oxPAPC) treatment alters T-reg differentiation and induces a Th1-like phenotype in surviving cells. Furthermore, oxPAPC-treated T-regs exhibit reduced suppressive function and are insufficient to inhibit atherosclerosis progression in mice. This study highlights the negative effect of oxidized phospholipids on T-reg differentiation and atheroprotective function.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nataliya Mushenkova, Evgeny E. Bezsonov, Varvara A. Orekhova, Tatyana Popkova, Antonina Starodubova, Alexander N. Orekhov
Summary: Atherosclerosis is a chronic disease with inflammatory components, now recognized as an active autoimmune process involving both innate and adaptive immune pathways. One of the key factors driving this process is the presence of modified LDL, which leads to the formation of oxidation-specific epitopes recognized by immune cells. Macrophage response to these epitopes is crucial for initiating and promoting inflammation in the arteries.
Article
Biochemistry & Molecular Biology
Christina Mauerhofer, Taras Afonyushkin, Olga Oskolkova, Klara Hellauer, Bernd Gesslbauer, Jasmin Schmerda, Yunbo Ke, Andreas Zimmer, Anna A. Birukova, Konstantin G. Birukov, Valery Bochkov
Summary: Oxidized phospholipids (OxPLs) can protect endothelial cells from stress-induced damage by extracting membrane cholesterol and inducing the expression of heat shock proteins and pro-survival factors.
Review
Medicine, General & Internal
Amalia Despoina Koutsogianni, Evangelos Liberopoulos, Konstantinos Tellis, Alexandros D. Tselepis
Summary: The article summarizes the data on OxPLs and cardiovascular risk, as well as the impact of hypolipidemic medications on Lp(a) and OxPLs.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Maryam Darabi, Marie Lhomme, Veronica D. Dahik, Isabelle Guillas, Eric Frisdal, Emilie Tubeuf, Lucie Poupel, Mili Patel, Emmanuel L. Gautier, Thierry Huby, Maryse Guerin, Kerry-Anne Rye, Philippe Lesnik, Wilfried Le Goff, Anatol Kontush
Summary: Phosphatidylserine (PS) is a component of high-density lipoprotein (HDL) that exhibits potent anti-inflammatory activity. This study found that the incorporation of PS into reconstituted HDL enhanced its anti-inflammatory effects by modulating signaling pathways mediated by SR-BI.
Article
Peripheral Vascular Disease
Takeshi Okada, Mizuki Sumida, Tohru Ohama, Yuki Katayama, Ayami Saga, Hiroyasu Inui, Kotaro Kanno, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
Summary: A novel sandwich ELISA for Ox-HDL was developed to evaluate HDL functionality, with healthy subjects having levels of 28.5 ± 5.0 U/L and dyslipidemic patients showing higher levels, especially in patients with hyperalphalipoproteinemia due to cholesteryl ester transfer protein deficiency. Probucol treatment was associated with significantly lower Ox-HDL levels in patients with familial hypercholesterolemia.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Huijuan Dou, Andriana Kotini, Wenli Liu, Trevor Fidler, Kaori Endo-Umeda, Xiaoli Sun, Malgorzata Olszewska, Tong Xiao, Sandra Abramowicz, Mustafa Yalcinkaya, Brian Hardaway, Sotirios Tsimikas, Xuchu Que, Alexander Bick, Conor Emdin, Pradeep Natarajan, Eirini P. Papapetrou, Joseph L. Witztum, Nan Wang, Alan R. Tall
Summary: Hematopoietic Lnk deficiency promotes NETosis and arterial thrombosis. Individuals carrying the JAK2(VF) mutation along with the LNK R262W allele are at increased risk of coronary artery disease.
Article
Cell Biology
Michela Palmieri, Maria Almeida, Intawat Nookaew, Horacio Gomez-Acevedo, Teenamol E. Joseph, Xuchu Que, Sotirios Tsimikas, Xiaoli Sun, Stavros C. Manolagas, Joseph L. Witztum, Elena Ambrogini
Summary: Transgenic expression of E06-scFv helps attenuate age-related bone loss in mice by increasing bone density, osteoblasts, and decreasing osteoclasts. Additionally, it increases Wnt signaling, showing promise as a therapeutic target for senile osteoporosis.
Article
Biochemistry & Molecular Biology
Olga V. Oskolkova, Alma Hodzic, Pratap Karki, Bernd Gesslbauer, Yunbo Ke, Dina C. Hofer, Juliane G. Bogner-Strauss, Jean-Marie Galano, Camille Oger, Anna Birukova, Thierry Durand, Konstantin Birukov, Valery Bochkov
Summary: This study presents a method for synthesizing oxidized phospholipids containing oxylipins via an amide bond, which allows for high yield activation and attachment of oxylipins under mild conditions without the need for additional protection steps. The synthesized alkyl-amide oxidized phospholipids exhibit similar biological activities to di-acyl oxidized phospholipids, making them a potentially useful tool for further analysis of the structure-activity relationship of OxPLs.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Jin Kyung Seok, Eun-Hee Hong, Gabsik Yang, Hye Eun Lee, Sin-Eun Kim, Kwang-Hyeon Liu, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: Oxidized phospholipids, such as POVPC and PGPC, are found to promote epithelial-mesenchymal transition (EMT) and autophagy in cancer cells, leading to increased migration and invasion potential. Elevated levels of these oxidized phospholipids are observed in tumor tissues and are associated with enhanced metastatic abilities.
Article
Medicine, Research & Experimental
Alexander Sorokin, Christin G. Hong, Angel M. Aponte, Elizabeth M. Florida, Jingrong Tang, Nidhi Patel, Irina N. Baranova, Haiou Li, Philip M. Parel, Vicky Chen, Sierra R. Wilson, Emily L. Ongstad, Anna Collen, Martin P. Playford, Thomas L. Eggerman, Marcus Y. Chen, Kazuhiko Kotani, Alexander Bocharov, Alan T. Remaley
Summary: In this study, we found that oxidized apolipoprotein B and oxidized ApoA-I are associated with high-risk coronary plaque features and progression in patients with cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Aleksandra Stamenkovic, Kimberley A. O'Hara, David C. Nelson, Thane G. Maddaford, Andrea L. Edel, Graham Maddaford, Elena Dibrov, MohamadReza Aghanoori, Lorrie A. Kirshenbaum, Paul Fernyhough, Michel Aliani, Grant N. Pierce, Amir Ravandi
Summary: Oxidized phosphatidylcholines (OxPC) generated during reperfusion injury induce cardiomyocyte death through ferroptosis, which can be attenuated by neutralization of OxPC or with ferrostatin-1. Understanding this pathway may lead to novel strategies for preventing cell death during myocardial reperfusion injury.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)