Article
Immunology
Kiriakos Koukoulias, Penelope-Georgia Papayanni, Aphrodite Georgakopoulou, Maria Alvanou, Stamatia Laidou, Anastasios Kouimtzidis, Chrysoula Pantazi, Glykeria Gkoliou, Timoleon-Achilleas Vyzantiadis, Alexandros Spyridonidis, Antonios Makris, Anastasia Chatzidimitriou, Nikoletta Psatha, Achilles Anagnostopoulos, Evangelia Yannaki, Anastasia Papadopoulou
Summary: A new steroid-resistant T-cell product, Cb-STs, targeting multiple pathogens has been rapidly generated using CRISPR/CAS9 technology, offering broad benefits for patients, particularly those in need of high-dose steroid treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yumi Tamura, Keita Yamane, Yohei Kawano, Lars Bullinger, Tristan Wirtz, Timm Weber, Sandrine Sander, Shun Ohki, Yasuo Kitajima, Satoshi Okada, Klaus Rajewsky, Tomoharu Yasuda
Summary: Both CD4(+) T cells and CD8(+) T cells show similar gene expression patterns and cytotoxicity towards Epstein-Barr virus-infected B cells. This suggests that different subsets of T cells can be involved in immune surveillance through cytotoxicity during viral infections.
Article
Immunology
Jennifer Massey, Crisbel Artuz, Zoe Dyer, Katherine Jackson, Melissa Khoo, Malini Visweswaran, Barbara Withers, John Moore, David Ma, Ian Sutton
Summary: This study analyzed the immune responses to EBV before and after AHSCT in 13 MS patients, and found that the infused stem cell product contained EBV-infected memory B cells, and EBV viremia occurred in the immune-compromised recipient post-transplant. High throughput TCR analysis detected expansion and diversification of the CD8 CTL responses reactive with EBV lytic and latent antigens from 6 to 24 months following AHSCT. Increased levels of latent EBV infection found within the B cell pool following treatment did not associate with disease relapse.
CLINICAL IMMUNOLOGY
(2023)
Article
Hematology
Jeremy D. Rubinstein, Carolyn Lutzko, Thomas Leemhuis, Xiang Zhu, Giang Pham, Lorraine Ray, Shawn Thomas, Celeste Dourson, Jamie Wilhelm, Adam Lane, Jose A. Cancelas, Dakota Lipps, Justin Ferrell, Patrick J. Hanley, Michael D. Keller, Catherine M. Bollard, YunZu M. Wang, Stella M. Davies, Adam S. Nelson, Michael S. Grimley
Summary: Infections with double-stranded DNA viruses are a significant cause of morbidity and mortality in pediatric patients following allogeneic hematopoietic stem cell transplantation. Virus-specific T-cell therapies (VSTs) have been shown to be an effective treatment for these infections. This study assessed the feasibility of rapid manufacturing and early infusion of VSTs generated from stem cell donors into HSCT recipients.
Article
Pediatrics
Chen Cheng, Yu He, Sa Xiao, Qing Ai, Jialin Yu
Summary: Studies on NEC have not focused largely on enteric viruses, but recent research has shown that not all enteric viruses are pathogenic. ADV and EBV may be related to the severity of NEC, while some viruses like ASV may be commensal in neonates.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Andrea Aran, Vicente Peg, Rosa Maria Rabanal, Cristina Bernado, Esther Zamora, Elisa Molina, Yago A. Arribas, Joaquin Arribas, Jose Perez, Carme Roura-Mir, Montserrat Carrascal, Javier Cortes, Merce Marti
Summary: The study found a restricted T-cell repertoire in tumor tissue during xenograft progression, while T cells from the TNBC biopsy were expanded after transformation into B-cell line, resulting in a limited TCR repertoire. These results suggest that EBV+ B cells infiltrating the tumor as bystanders may interact with tumor-infiltrating T cells and influence the TCR repertoire.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Susan E. Prockop, Aisha Hasan, Ekaterina Doubrovina, Parastoo B. Dahi, Irene Rodriguez-Sanchez, Michael Curry, Audrey Mauguen, Genovefa A. Papanicolaou, Yiqi Su, JinJuan Yao, Maria Arcila, Farid Boulad, Hugo Castro-Malaspina, Christina Cho, Kevin J. Curran, Sergio Giralt, Nancy A. Kernan, Guenther Koehne, Ann Jakubowski, Esperanza Papadopoulos, Miguel-Angel Perales, Ioannis Politikos, Keith Price, Annamalai Selvakumar, Craig S. Sauter, Roni Tamari, Teresa Vizconde, James W. Young, Richard J. O'Reilly
Summary: The adoptive transfer of CMVpp65-sensitized T cells from a third-party donor can improve the prognosis for recipients of hematopoietic stem cell transplant with refractory CMV viremia and disease, providing potential new treatments for these patients.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Microbiology
Alexander Dowell, Tracey Haigh, Gordon Ryan, James Turner, Heather Long, Graham Taylor
Summary: Epstein Barr Virus (EBV) infects a large percentage of the population and establishes latent infection in B-cells. Efforts to develop EBV prophylactic vaccination have mainly focused on neutralising antibodies, but generating T-cell responses against EBV structural proteins could be a promising alternative strategy. Research has shown that EBV capsid proteins BcLF1, BDLF1, and BORF1 are frequent targets of T-cell responses, and CD4+ T-cells specific for these proteins can recognize and control newly EBV-infected cells, even in long-term viral carriage. This study highlights the potential of targeting structural antigens for prophylactic EBV vaccine development.
Article
Immunology
Jennifer A. Slyker, Brandon Guthrie, Mark Pankau, Kenneth Tapia, Dalton Wamalwa, Sarah Benki-Nugent, Evelyn Ngugi, Meei-Li Huang, Irene Njuguna, Agnes Langat, Grace John-Stewart, Dara Lehman
Summary: The study found that co-infections of CMV and EBV were associated with higher HIV reservoir levels in Kenyan children with suppressed HIV RNA, suggesting that delaying or controlling CMV and EBV infections may be novel strategies to limit HIV reservoir formation.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Oncology
Amanda Olson, Ruitao Lin, David Marin, Hind Rafei, Mustafa H. Bdaiwi, Peter F. Thall, Rafet Basar, Ala Abudayyeh, Pinaki Banerjee, Fleur M. Aung, Indresh Kaur, Glorette Abueg, Sheetal Rao, Roy Chemaly, Victor Mulanovich, Gheath Al-Atrash, Amin M. Alousi, Borje S. Andersson, Paolo Anderlini, Qaiser Bashir, Karla M. Castro, May Daher, Isabel M. Galvan, Chitra Hosing, Jin S. Im, Roy B. Jones, Partow Kebriaei, Issa Khouri, Rohtesh Mehta, Jeffrey Molldrem, Yago Nieto, Betul Oran, Uday Popat, Muzaffar Qazilbash, Gabriela Rondon, Neeraj Saini, Bryan Spencer, Samer Srour, Dominique Washington, Melissa Barnett, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Summary: The study shows that treatment with BKV-specific CTLs is safe and effective for managing patients with BKV-HC after AHSCT. The response rate is rapid, with overall response rates of 67.7% at day 14 and 81.6% at day 45. Compared to standard care, treatment with BKV-CTLs results in higher response probabilities and lower transfusion requirements.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Virology
Agnieszka Jablonska, Branislav Zagrapan, Edyta Paradowska, Christoph Neumayer, Wolf Eilenberg, Christine Brostjan, Markus Klinger, Josif Nanobachvili, Ihor Huk
Summary: The study found that CMV infection may stimulate local inflammation in the aorta but is not a direct cause of most abdominal aortic aneurysms.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Pathology
Hung-Lin Liu, Shao-Wen Weng, Chih-Chi Chou, Huey-Ling You, Ming-Chung Wang, Ming-Chun Ma, Wan-Ting Huang
Summary: This study found that the level of FOXP3 expression is closely related to the clinical features and prognosis of AITL patients. Low FOXP3 expression is associated with increased risk of disease progression and recurrence. Therefore, the expression level of FOXP3 is of great significance for risk stratification and determination of treatment strategies for AITL patients.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Immunology
Jing Cai, Bodou Zhang, Yuqi Li, Wanfang Zhu, Toshihiro Akihisa, Wei Li, Takashi Kikuchi, Wenyuan Liu, Feng Feng, Jie Zhang
Summary: The lack of approved EBV vaccines can be attributed to the complexity of the virus life cycle, the absence of suitable animal models, and limited understanding of adjuvant selection and immune responses. Continuous research and trials show that combined immunization could be crucial for the future success in developing EBV vaccines.
Article
Dentistry, Oral Surgery & Medicine
Jaideep Mahendra, Little Mahendra, Dhana Divya, Paavai Ilango, Nalini Devarajan, Abirami Thanigaimalai
Summary: This study evaluates and compares the levels of lipocalin, adiponectin, and periodontal viruses in generalized periodontitis patients with and without diabetes mellitus. The results show that patients with diabetes and periodontitis have higher prevalence of EBV and CMV, as well as decreased levels of adiponectin, indicating an aggravation of the diabetic status among periodontitis patients and reinforcing the Periodontitis-DM continuum.
Review
Oncology
Ivonne A. Montes-Mojarro, Falko Fend, Leticia Quintanilla-Martinez
Summary: ENKTCL is an aggressive lymphoma associated with EBV infection, characterized by activation of the JAK-STAT pathway and mutations in genes like BCOR, DDX3X and TP53. Differences in EBV strains and LMP1 variants among populations provide insights into the pathogenesis and genetics of ENKTCL. The genetic landscape of ENKTCL highlights mechanisms of lymphomagenesis and potential therapeutic targets.