Article
Virology
Xizi Deng, Zhiwei Liang, Weiping Cai, Feng Li, Junbin Li, Fengyu Hu, Yun Lan
Summary: This study revealed the diversity and distribution of HCV subgenotypes among HIV/HCV-coinfected patients in Guangdong, China. Marital status was found to potentially influence the formation of HCV transmission networks.
Article
Gastroenterology & Hepatology
Penglei Jiang, Hongyu Jia, Xinyue Qian, Tian Tang, Yingli Han, Zhaoru Zhang, Lingli Jiang, Zebin Yu, Lin Zheng, Guodong Yu, Huan Cai, Shanyan Zhang, Xiaoli Zhang, Jueqing Gu, Chanyuan Ye, Lisha Yang, Yingfeng Lu, Heng Liu, Xiaoqing Lu, Ciliang Jin, Yue Ren, Miaomiao Lu, Lingling Xu, Jiong Yu, Xi Jin, Yida Yang, Pengxu Qian
Summary: This study used single-cell RNA sequencing to investigate the transcriptomic landscape of peripheral immune cells in CHB patients before and after PegIFN-alpha therapy. The study identified specific cell subsets associated with CHB and found that PegIFN-alpha treatment could decrease hyperactivated monocytes, increase long-lived naive/memory T cells, and enhance effector T cell cytotoxicity. Furthermore, the treatment altered the transcriptional profiles of immune cells and enhanced innate antiviral response.
Article
Medicine, General & Internal
Ilona Argirion, Parag Mahale, Ruth M. Pfeiffer, Ping Liu, Adaora A. Adimora, Matthew J. Akiyama, Hector H. Bolivar, Audrey French, Michael Plankey, Jennifer C. Price, Aadia Rana, Anandi Sheth, Jill Koshiol, Eric C. Seaberg, Mark H. Kuniholm, Jeffrey Glenn, Thomas R. O'Brien
Summary: HBV infection is more common among HIV-infected women, while HDV infection primarily occurs with participants enrolled during 2013-2015 and HBV carriers. Among HBsAg-positive women, HDV infection is associated with the presence of advanced fibrosis/cirrhosis. These results highlight the importance of HDV testing in HBV-infected US women.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Jeffrey R. Quinn, Ashish Goyal, Ruy M. Ribeiro, Guido Massaccesi, Justin R. Bailey, David L. Thomas, Ashwin Balagopal
Summary: This study provides the first evidence that ART reduces the intrahepatic burden of HCV and suggests that HIV affects the pathogenesis of HCV infection through an NK/NK T-cell-mediated mechanism that may involve HLA-E and can be rescued, at least in part, by ART.
Article
Virology
Yung-Ju Yeh, Ching-Ping Tseng, Sheng-Da Hsu, His -Yuan Huang, Michael M. C. Lai, Hsien-Da Huang, Ju-Chien Cheng
Summary: MicroRNA let-7b is induced by HCV infection and directly targets the HCV genome to regulate HCV replication. Through targeting negative regulators of IFN signaling, let-7b enhances IFN expression and signaling to limit HCV replication in the early stage of infection. This study sheds new insight into the role of let-7b in combating HCV infection and understanding the initial defense mechanisms against RNA viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Oguz Kagan Bakkaloglu, Ozgen Yildirim, Bilger Cavus, Sami Evirgen, Suut Gokturk, Asli Ormeci, Ozlem Soyer, Filiz Akyuz, Kadir Demir, Sabahattin Kaymakoglu, Mine Gulluoglu, Cetin Karaca
Summary: Chronic delta hepatitis (CDH) has a worse outcome than other types of viral hepatitis. High-dose, long-term alpha interferon (IFN-alpha) is the approved treatment but does not change the natural course of CDH.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Gastroenterology & Hepatology
Norah A. Terrault, Miriam T. Levy, Ka Wang Cheung, Gonzague Jourdain
Summary: The management of viral hepatitis in pregnancy requires special consideration due to the unique characteristics of each hepatitis virus and their impact on maternal and infant outcomes. Preventing mother-to-child transmission is crucial in reducing the global burden of chronic viral hepatitis.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Immunology
Shu-Ming Chou, Hsing-Jung Yeh, Tzu-Min Lin, Yu-Sheng Chang, Hui-Ching Hsu, Yu-Chuan Shen, Tzu-Tung Kuo, Jin-Hua Chen, Shu-Chuan Chen, Chi-Ching Chang
Summary: This study found that the use of interferon-based therapy (IBT) in patients with HCV infection increased the risk of autoimmune thyroid diseases (Hashimoto's thyroiditis and Graves' disease), but did not have a significant impact on the overall and systemic autoimmune diseases risk.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Felix Lang, Klaus Schoene, Felix Goessler, Dirk-Matthias Rose, Peter Kegel
Summary: The aim of this study was to assess the occupational biological hazards related to hepatitis A and hepatitis B in schools for pupils with special needs and to determine the need for occupational health care. The survey found that teachers and educational specialists had frequent physical contact with students and engaged in hazardous activities. The vaccination rate was low, with lack of vaccine counseling and non-participation in infection prevention instruction being significant predictors of low vaccination rates.
SCIENTIFIC REPORTS
(2022)
Review
Public, Environmental & Occupational Health
S. Mehmandoost, M. Khezri, G. Mousavian, F. Tavakoli, F. Mehrabi, H. Sharifi, K. Dolan, M. Shokoohi
Summary: This study systematically summarized the prevalence of HIV, HBV, and HCV infections among incarcerated people in Iran. The results showed that the prevalences of these infections are relatively high in this population. Meta-analysis and regression analysis found a decrease in HIV and HCV infections over time.
Article
Multidisciplinary Sciences
Beatriz Alvarez, Maria A. Navarrete-Munoz, Veronica Briz, Susana Olmedillas-Lopez, Sara Nistal, Alfonso Cabello, Laura Prieto, Miguel Gorgolas, Mariano Garcia-Arranz, Jose M. Benito, Norma Rallon
Summary: This study assessed the impact of HCV eradication on HIV-DNA content in HIV/HCV-coinfected patients treated with direct-acting antivirals. The results suggest that HCV does not influence the size of the HIV reservoir and that DAAs do not have an anti-HIV action.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Anthony E. Ades, Fabiana Gordon, Karen Scott, Intira J. Collins, Thorne Claire, Lucy Pembrey, Elizabeth Chappell, Eugenia Marine-Barjoan, Karina Butler, Giuseppe Indolfi, Diana M. Gibb, Ali Judd
Summary: This study provides new estimates of the risk of vertical transmission of hepatitis C virus (HCV). The overall vertical transmission rates are higher than previously assumed, but the risk of infection persisting beyond age 5 years is lower.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Chen-Hua Liu, Hsin-Yun Sun, Cheng-Yuan Peng, Szu-Min Hsieh, Sheng-Shun Yang, Wei-Yu Kao, Yu-Lueng Shih, Chih-Lin Lin, Chun-Jen Liu, Wang-Hui Sheng, Yi-Chun Lo, Wen-Chun Liu, Jo-Hsuan Wu, Tung-Hung Su, Tai-Chung Tseng, Pei-Jer Chen, Chien-Ching Hung, Jia-Horng Kao
Summary: This study investigated the risk of hepatitis C virus (HCV) reinfection in HIV/HCV-coinfected patients in Taiwan after treatment-induced sustained virologic response (SVR). The results showed that the risk of HCV reinfection remained high in HIV-positive patients with SVR12, and the incidence of HCV reinfection increased after the availability of direct-acting antivirals (DAAs) in Taiwan.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Adriana Palom, Sara Sopena, Mar Riveiro-Barciela, Angela Carvalho-Gomes, Antonio Madejon, Sergio Rodriguez-Tajes, Luisa Roade, Maria Garcia-Eliz, Javier Garcia-Samaniego, Sabela Lens, Marina Berenguer-Hayme, Francisco Rodriguez-Frias, Helena Hernandez-Evole, Ana Isabel Gil-Garcia, Ana Barreira, Rafael Esteban, Maria Buti
Summary: This study evaluated changes in serum HDV-RNA concentrations in 56 untreated chronic hepatitis delta (CHD) patients. Results showed that 25% of patients had a >= 2 log(10) decline in HDV-RNA levels, while 20% achieved undetectable HDV-RNA over a mean follow-up of 5.6 years. The decline was associated with ALT decrease.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Immunology
Sanyog G. Shitole, Jason M. Lazar, David B. Hanna, Ryung S. Kim, Kathryn Anastos, Mario J. Garcia, Phyllis C. Tien, Joao A. C. Lima, Robert C. Kaplan, Jorge R. Kizer
Summary: Long-term study on middle-aged women revealed that HCV infection is significantly associated with an increased risk of incident LV dysfunction, while there is no clear correlation or impact from HIV infection. These findings support recommendations for expanding HCV screening and treatment.