Journal
CURRENT OPINION IN INFECTIOUS DISEASES
Volume 23, Issue 5, Pages 470-474Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QCO.0b013e32833da1eb
Keywords
Bacteroides; diarrhea; enterotoxigenic Bacteroides fragilis
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Funding
- NIDDK NIH HHS [R01 DK045496-15, R01 DK059655-01, R01 DK059655-02, R01 DK045496, R01 DK045496-14, R01 DK080817-03, R01 DK080817-01, R01 DK045496-17, R01 DK059655-03, R01 DK045496-13, R01 DK045496-16, R01 DK080817-04, R01 DK080817, R01 DK045496-18, R01 DK059655, R01 DK080817-02] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK045496, R01DK059655, R01DK080817] Funding Source: NIH RePORTER
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Purpose of review The purpose of this review is to describe recent progress in the understanding of the role of Bacteroides spp. in human diarrheal diseases and newer murine studies implicating certain Bacteroides spp. in colorectal cancer. Recent findings Bacteroides fragilis is the only strain of Bacteroides spp. associated with diarrheal disease. Toxin-producing strains of B. fragilis, termed enterotoxigenic Bacteroides fragilis (ETBF), are an established cause of diarrheal disease in people. The clinical syndrome associated with ETBF diarrheal disease encompasses abdominal pain, tenesmus and inflammatory diarrhea. Two new studies conducted in mice have further defined the chronic inflammatory response associated with ETBF infection and observed that in the multiple intestinal neoplasia mouse strain, heterozygotes for the adenomatous polyposis coli gene, ETBF infection enhances development of colonic tumors. Separate murine studies have begun to define the role of nontoxin-producing B. fragilis as a symbiont, serving possibly to protect the host from colonic inflammation. Summary B. fragilis remains the leading anaerobe in human disease. ETBF is emerging as an important cause of human diarrheal disease but additional epidemiologic studies are needed to better understand the role of ETBF human disease.
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