Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 23, Issue 1, Pages 138-145Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.11.012
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Funding
- National Institutes of Health [R01 DK074500, P01 AI045757]
- Baruj Benaceraff Postdoctoral Fellowship
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The induction and maintenance of T cell tolerance is essential to prevent autoimmunity. A combination of central and peripheral mechanisms acts to control autoreactive T cells. In secondary lymphoid organs, dendritic cells (DCs) presenting self-antigen were thought to play a major role in the induction of peripheral T cell tolerance. Multiple recent studies have demonstrated that DCs are not absolutely essential to induce and maintain tolerance. Furthermore, it has also been recently shown that non-hematopoietic stromal cells expressing peripheral tissue-restricted antigens can induce T cell tolerance, independently of DCs. Together these studies imply that peripheral tolerance is more complex than previously thought and a consequence of the tolerogenic functions of the hematopoietic and non-hematopoietic compartments within secondary lymphoid organs.
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