Review
Immunology
Angelina De Martin, Yves Stanossek, Natalia Barbara Pikor, Burkhard Ludewig
Summary: This article discusses the biology of fibroblastic reticular cells (FRCs) in lymphoid organs and their role in activating or attenuating immune responses. FRCs provide structural support in secondary lymphoid organs and guide immune cells to specialized microenvironments. Adverse reprogramming of FRCs can lead to immunopathological tissue damage during infection and autoimmune conditions, as well as subvert antitumor immune responses.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Orest Tsymbalyuk, Volodymyr Gerzanich, J. Marc Simard, Chozha Vendan Rathinam
Summary: This study investigates the impact of traumatic brain injury (TBI) on dendritic cells (DCs), the most professional antigen presenting cells of the immune system. The results show that the distribution and function of DC subsets in both lymphoid and non-lymphoid organs are imbalanced following TBI. Furthermore, TBI leads to reduced levels of reactive oxygen species (ROS) in DCs, which may explain the altered differentiation of DCs after TBI. The findings of this study are important in understanding the molecular mechanisms underlying DC defects after TBI and can be beneficial in treating infections in patients with acute central nervous system injuries.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Malgorzata Anna Cichon, Katharina Klas, Maria Buchberger, Martina Hammer, Kristin Sere, Martin Zenke, Erwin Tschachler, Adelheid Elbe-Burger
Summary: The study found that RTN1A is expressed not only in neural tissue but also in skin dendritic cells, especially LCs. The expression of RTN1A in lymph nodes and spleen suggests its potential important role in immune cells, while its expression in skin nerves is also noteworthy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yiming Cao, Jinrong Long, Huisheng Sun, Yiqi Miao, Ye Sang, Haitao Lu, Changxiao Yu, Zhen Zhang, Lin Wang, Jing Yang, Shengqi Wang
Summary: Dendritic cell-mimicking nanoparticles (DCMNPs) are developed as a novel mRNA delivery carrier, which can effectively deliver mRNA to lymphatic organs. DCMNPs showed efficient protein expression in both the spleen and lymph nodes after intramuscular injections.
Review
Immunology
Angela Boahen, Dailun Hu, Murray J. Adams, Philip K. Nicholls, Wayne K. Greene, Bin Ma
Summary: This review explores the connections between the central nervous system (CNS) and the peripheral nervous system (PNS) with the immune system, focusing on the impact of these interactions on health and disease. Understanding these neuroimmune interactions could lead to new therapeutic approaches for neurological, neuroimmunological, infectious, inflammatory, and immunological disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
Summary: The lungs have an immune defense mechanism that uses various cells to eliminate harmful pathogens and activate T cell immune response. In addition to immune cells, other lung cells also participate in antigen presentation and T cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ho-Sup Lee, Hao Sun, Frederic Lagarrigue, Sarah Hyun Ji Kim, Jay W. Fox, Nicholas E. Sherman, Alexandre R. Gingras, Mark H. Ginsberg
Summary: The study reveals that Phostensin (Ptsn) is a component of the Mig-10/RIAM/Lamellipodin (MRL protein)-integrin-talin (MIT) complex and plays a role in stabilizing the complex by dephosphorylating Rap1. This stabilization enhances lymphocyte integrin-mediated functions and loss of Ptsn ameliorates T cell-mediated colitis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Immunology
Christophe Macri, Devi Jenika, Cassandra Ouslinis, Justine D. Mintern
Summary: Dendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in adaptive immunity. Targeting antigen directly to DCs is a selective vaccination strategy that takes advantage of the antigen uptake and presentation functions of DC subsets. This review focuses on DC-targeted vaccination strategies aimed at inducing effective cross-presentation for CD8+ T cell immunity. Receptors highly expressed by mouse and human cDCs, such as DEC205, Clec9A, and XCR1, are explored. The outcomes of DC-targeted vaccination in mouse models and human clinical trials are discussed, highlighting its potential for the prevention and treatment of tumors and infectious diseases.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Immunology
Qun Xiang, Zeqing Feng, Bo Diao, Chao Tu, Qinghua Qiao, Han Yang, Yi Zhang, Gang Wang, Huiming Wang, Chenhui Wang, Liang Liu, Changsong Wang, Longding Liu, Rong Chen, Yuzhang Wu, Yongwen Chen
Summary: The study retrospectively reviewed clinical and immunological data from fatal COVID-19 cases and found severe lymphocytopenia with high levels of inflammatory cytokines. Post-mortem examinations of additional cases showed severe tissue damage and lymphocyte apoptosis in spleens and lymph nodes, where SARS-CoV-2 viral RNA accumulates, leading to lymphocytopenia. Overall, the results suggest that SARS-CoV-2 induces lymphocytopenia by promoting systemic inflammation and direct damage to human spleen and lymph nodes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Alice Coillard, Elodie Segura
Summary: This study reviews the research on mouse mo-DC, evaluates the in vivo evidence for monocyte-derived antigen-presenting cells, and proposes that mo-DC may present antigens to effector T cells locally in tissues, playing a complementary role to cDCs.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Sophie Flommersfeld, Jan P. Bottcher, Jonatan Ersching, Michael Flossdorf, Philippa Meiser, Ludwig O. Pachmayr, Justin Leube, Inge Hensel, Sebastian Jarosch, Qin Zhang, M. Zeeshan Chaudhry, Immanuel Andrae, Matthias Schiemann, Dirk H. Busch, Luka Cicin-Sain, Joseph C. Sun, Georg Gasteiger, Gabriel D. Victora, Thomas Hoefer, Veit R. Buchholz, Simon Grassmann
Summary: Upon viral infection, NK cells with specific receptors undergo an adaptive-like response, with two distinct NK cell lineages identified to contribute to this response. ILC1-like NK cells exhibit strong cytokine production, ability to recognize and kill infected cells, and bridge innate and adaptive viral recognition, showing features of both cNK cells and ILC1s.
Review
Immunology
Ray A. Ohara, Kenneth M. Murphy
Summary: Cross-priming, initially recognized in cytotoxic T lymphocyte (CTL) responses, involves the presentation of minor histocompatibility antigens by antigen presenting cells (APCs) derived from immunizing cells. As understanding of T cell receptor antigen recognition progressed, cross-priming was redefined as cross-presentation and expanded to include different forms of antigens and APCs not involved in in vivo CTL priming. In vitro cell models have been utilized for studying cross-presentation, but recent studies have shown differences between these models and in vivo APCs. Current research focuses on validating in vivo pathways and gene candidates for cross-presentation, and evaluating their contributions to CTL responses across different antigens and immunologic settings.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Patricia Cunha, Florence B. Gilbert, Jennifer Bodin, Lise Godry, Pierre Germon, Sebastien Holbert, Rodrigo Prado Martins
Summary: Dendritic cells are important for understanding the immune response and can be produced in a simplified manner using conventional and serum-free media. These cells can be used for flow cytometry-based antigen presentation assays with fresh or frozen cells. The simplified protocols described in this study are significant for studying cell-mediated immune responses in bovine.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
Ryosuke Tashiro, Kuniyasu Niizuma, Jun Kasamatsu, Yuko Okuyama, Sherif Rashad, Atsuo Kikuchi, Miki Fujimura, Shigeo Kure, Naoto Ishii, Teiji Tominaga
Summary: The study found that RNF213 plays a critical role in antigen uptake, processing, and presentation, with Rnf213-KO and Rnf213-KI mice experiments showing that RNF213 deficiency leads to decreased antigen uptake and processing capabilities, resulting in the inability to effectively activate antigen-specific T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Jarem Edwards, James S. Wilmott, Jason Madore, Tuba Nur Gide, Camelia Quek, Annie Tasker, Angela Ferguson, Jinbiao Chen, Rehana Hewavisenti, Peter Hersey, Thomas Gebhardt, Wolfgang Weninger, Warwick J. Britton, Robyn P. M. Saw, John F. Thompson, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, Umaimainthan Palendira
CLINICAL CANCER RESEARCH
(2018)
Review
Immunology
Katharina Hochheiser, Andrew J. Kueh, Thomas Gebhardt, Marco J. Herold
EUROPEAN JOURNAL OF IMMUNOLOGY
(2018)
Review
Immunology
Thomas Gebhardt, Umaimainthan Palendira, David C. Tscharke, Sammy Bedoui
IMMUNOLOGICAL REVIEWS
(2018)
Article
Immunology
Simone L. Park, Ali Zaid, Jyh Liang Hor, Susan N. Christo, Julia E. Prier, Brooke Davies, Yannick O. Alexandre, Julia L. Gregory, Tiffany A. Russell, Thomas Gebhardt, Francis R. Carbone, David C. Tscharke, William R. Heath, Scott N. Mueller, Laura K. Mackay
Article
Multidisciplinary Sciences
Joseph M. Benoun, Newton G. Peres, Nancy Wang, Oanh H. Pham, Victoria L. Rudisill, Zachary N. Fogassy, Paul G. Whitney, Daniel Fernandez-Ruiz, Thomas Gebhardt, Quynh-Mai Pham, Lynn Puddington, Sammy Bedoui, Richard A. Strugnell, Stephen J. McSorley
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Immunology
Christopher M. Harpur, Yu Kato, Shinta T. Dewi, Sanda Stankovic, Darryl N. Johnson, Sammy Bedoui, Paul G. Whitney, Mireille H. Lahoud, Irina Caminschi, William R. Heath, Andrew G. Brooks, Thomas Gebhardt
JOURNAL OF IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Simone L. Park, Anthony Buzzai, Jai Rautela, Jyh Liang Hor, Katharina Hochheiser, Maike Effern, Nathan McBain, Teagan Wagner, Jarem Edwards, Robyn McConville, James S. Wilmott, Richard A. Scolyer, Thomas Tueting, Umaimainthan Palendria, David Gyorki, Scott N. Mueller, Nicholas D. Huntington, Sammy Bedoui, Michael Hoelzel, Laura K. Mackay, Jason Waithman, Thomas Gebhardt
Correction
Multidisciplinary Sciences
Simone L. Park, Anthony Buzzai, Jai Rautela, Jyh Liang Hor, Katharina Hochheiser, Maike Effern, Nathan McBain, Teagan Wagner, Jarem Edwards, Robyn McConville, James S. Wilmott, Richard A. Scolyer, Thomas Tuting, Umaimainthan Palendira, David Gyorki, Scott N. Mueller, Nicholas D. Huntington, Sammy Bedoui, Michael Holzel, Laura K. Mackay, Jason Waithman, Thomas Gebhardt
Article
Multidisciplinary Sciences
Artika P. Nath, Asolina Braun, Scott C. Ritchie, Francis R. Carbone, Laura K. Mackay, Thomas Gebhardt, Michael Inouye
Article
Immunology
Angus T. Stock, Nicholas Collins, Gordon K. Smyth, Yifang Hu, Jacinta A. Hansen, Damian B. D'Silva, Hamdi A. Jama, Andrew M. Lew, Thomas Gebhardt, Catriona A. McLean, Ian P. Wicks
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Annabel Bachem, Christina Makhlouf, Katrina J. Binger, David P. de Souza, Deidra Tull, Katharina Hochheiser, Paul G. Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M. Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E. Russ, Ian A. Parish, Axel Kallies, Malcolm J. McConville, Stephen J. Tumer, Thomas Gebhardt, Sammy Bedoui
Editorial Material
Immunology
Francis R. Carbone, Thomas Gebhardt
SCIENCE IMMUNOLOGY
(2019)
Editorial Material
Cell Biology
Katharina Hochheiser, David E. Gyorki, Thomas Gebhardt
IMMUNOLOGY AND CELL BIOLOGY
(2020)
