Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 22, Issue 6, Pages 814-820Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.10.018
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Basophils are important effector cells, which contribute to protection against helminths and execute proinflammatory effector function during allergic inflammation. Basophils are also regulators of Th2 responses in helminth-infected hosts and in allergen-injected animals. Recently, three groups using different experimental systems have shown that basophils are antigen-presenting cells (APC), which induce Th2 cells both in vitro and in vivo. Basophils express MHC class II and CD80/86, have the potential to take-up and process protein antigen (Ag), particularly Ag-IgE complexes, and to present peptide with MHC class II and produce IL-4. However, relevance of basophils as Th2 cell-inducing APC in vivo has been challenged by several recent reports that favor the concept that basophils and DC cooperate or basophils merely amplify DC-driven Th2 cell differentiation. In this review, I summarize and discuss the data on the role of basophils as Th2 cell-inducing APC in allergy and parasite infection.
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