New insights into sickle cell disease

Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease

(2012) C. J. Bean et al.   BLOOD

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Effects of hypoxia and HIFs on cancer metabolism

(2012) Vera Mucaj et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Nitric oxide-mediated suppression of 2,3-bisphosphoglycerate synthesis: Therapeutic relevance for environmental hypoxia and sickle cell disease

(2012) R. Bertrand   MEDICAL HYPOTHESES

A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion

(2012) Felix Kopp et al.   Nature Chemical Biology

Sickle Hemoglobin Confers Tolerance to Plasmodium Infection

(2011) Ana Ferreira et al.   CELL

Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis

(2011) Mark T. Gladwin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia inducible factor 1 (HIF-1) and cardioprotection

(2010) Demet Tekin et al.   ACTA PHARMACOLOGICA SINICA

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

A Central Role of Heme Oxygenase-1 in Cardiovascular Protection

(2010) Meng-Ling Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme Oxygenase in the Regulation of Vascular Biology: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Young-Myeong Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Sickle cell anemia and vascular dysfunction: The nitric oxide connection

(2010) Idowu Akinsheye et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease

(2010) John D. Belcher et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Detrimental effects of adenosine signaling in sickle cell disease

(2010) Yujin Zhang et al.   NATURE MEDICINE

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-  and CXCR3 chemokines

(2009) K. L. Wallace et al.   BLOOD

Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling

(2009) Jiaming Wen et al.   FASEB JOURNAL

Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription Is Coupled with Eviction of Promoter Histones

(2009) Jason E. Fish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine Signaling, Priapism and Novel Therapies

(2009) Yingbo Dai et al.   Journal of Sexual Medicine

Role of Adenosine Signaling in Penile Erection and Erectile Disorders

(2009) Prasad V. Phatarpekar et al.   Journal of Sexual Medicine

Adenosine Deaminase Enzyme Therapy Prevents and Reverses the Heightened Cavernosal Relaxation in Priapism

(2009) Jiaming Wen et al.   Journal of Sexual Medicine

Nitrite as regulator of hypoxic signaling in mammalian physiology

(2009) Ernst E. van Faassen et al.   MEDICINAL RESEARCH REVIEWS

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

(2009) E. Seixas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

(2008) Tiejuan Mi et al.   JOURNAL OF CLINICAL INVESTIGATION