Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 53, Issue -, Pages 98-104Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2018.07.006
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Funding
- International Center for Genetic Engineering and Biotechnology (ICGEB) [CRP/MEX15-04_ EC]
- NIH [U01HG009080, U01HG007417, R01HL104608]
- NSF Social, Behavioral & Economic Sciences Postdoctoral Research Fellowship (NSF) [1711982]
- SBE Off Of Multidisciplinary Activities
- Direct For Social, Behav & Economic Scie [1711982] Funding Source: National Science Foundation
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Hispanic/Latino (H/L) populations, although linked by culture and aspects of shared history, reflect the complexity of history and migration influencing the Americas. The original settlement by indigenous Americans, followed by postcolonial admixture from multiple continents, has yielded localized genetic patterns. In addition, numerous H/L populations appear to have signatures of pre-colonization and post-colonization bottlenecks, indicating that tens of millions of H/Ls may harbor signatures of founder effects today. Based on both population and medical genetic findings we highlight the extreme differentiation across the Americas, providing evidence for why H/Ls should not be considered a single population in modern human genetics. We highlight the need for additional sampling of understudied H/L groups, and ramifications of these findings for genomic medicine in onetenth of the world's population.
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