Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 19, Issue 6, Pages 571-578Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2009.09.007
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Funding
- NLM [5T15LM007359]
- Human Frontiers Science Program
- NSF [0447887]
- NIGMS [R01GM083989-01]
- HHMI
- Burroughs Wellcome Fund
- Sloan Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM083989] Funding Source: NIH RePORTER
- NATIONAL LIBRARY OF MEDICINE [T15LM007359] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD003958] Funding Source: NIH RePORTER
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Regulatory divergence is likely a major driving force in evolution. Comparative transcriptomics provides a new glimpse into the evolution of gene regulation. Ascomycota fungi are uniquely suited among eukaryotes for studies of regulatory evolution, because of broad phylogenetic scope, many sequenced genomes, and facility of genomic analysis. Here we review the substantial divergence in gene expression in Ascomycota and how this is reconciled with the modular organization of transcriptional networks. We show that flexibility and redundancy in both cis-regulation and trans-regulation can lead to changes from altered expression of single genes to wholesale rewiring of regulatory modules. Redundancy thus emerges as a major driving force facilitating expression divergence while preserving the coherent functional organization of a transcriptional response.
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